Predictive factors of successful sperm retrieval on microdissection testicular sperm extraction in Japanese men

Abstract

Spermatozoa are significantly less likely to be successfully retrieved by micro-TESE in men with idiopathic azoospermia.

Endocrine Tests and/or Testicular Volume Are Not Predictive of Successful Sperm Retrieval by Multiple Testicular Sperm Extraction in Non-Obstructive Azoospermia

“…However, they found no signi cant effects on testicular volume, FSH, LH, or testosterone on sperm retrieval. [20] Our data also found no signi cance difference of LH value between the two groups in OA and NOA patients (P>0.05)…”

“…Tang WH et al and Enatsu N et al found that the testicular volume of the successful sperm retrieval group was higher than that of the unsuccessful sperm retrieval group, however there was no statistical signi cance between the two groups. [20,34] Salehi et al (2017) performed TESE and micro-TESE in 170 NOA patients and found that the sperm recovery rate was 48.8% and that testicular volume was related to the surgical sperm retrieval results (OR,10.5, P<0.01). [16] The result was similar to Boitrelle's study.…”

“…Furthermore, a variety of optimal cut-off values for testes volume and endocrine pro les for infertile males have been reported. [9,[17][18][19][20][21][22] This is possibly due to the effects of the study population and ethnicity. [23] This study aimed to determine the role of pre-surgical markers in the prediction of sperm retrieval in infertile men with azoospermia in a Vietnamese population.…”

The development of surgical sperm extraction and new challenges to improve the outcome

“…A large number of studies have reported that the outcomes of micro-TESE are more favorable than those of conventional single or multiple TESE, such that it is now regarded as the first-line treatment for men with NOA [24][25][26]. However, the successful sperm retrieval rates by micro-TESE in men with NOA remain unsatisfactory, ranging between 30 and 60 % [24,25,[27][28][29]. Furthermore, micro-TESE requires a significant learning curve and long operative time [26,27].…”

The role of surgical sperm retrieval techniques in patients with azoospermia in assisted reproductive technology programs (literature review)

“…Во многих исследованиях показано, что результаты microTESE лучше, чем результаты стандартной или мультифокальной TESE [22][23][24]. Тем не менее при НОА даже microTESE эффективна лишь в 30-60 % случаев [22,23,[25][26][27]. Возможность выполнения microTESE ограничивают необходимость оборудованной операционной и высококвалифицированных специалистов, а также большая длительность данного вмешательства [24,25].…”