Predictive factors of successful sperm retrieval in azoospermia

Bonarriba, Carlo R.; Burgués, J.P.; Vidaña, V. Tubau; Ruíz, Xavier; Piza, Pedro de Toledo

doi:10.1016/j.acuroe.2012.06.008

Cited by 14 publications

(16 citation statements)

References 28 publications

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“…Many factors were studied mainly testicular size, hormonal profile mainly FSH, karyotyping, Y chromosome microdeletion and testicular histopathology. Only Y chromosome microdeletion and testicular histopathology showed a reliable predictive value for sperm retrieval (Pantke et al ., ; Abdel Raheem et al ., ; Bonarriba et al ., ).…”

Section: Discussionmentioning

confidence: 97%

Outcome of microsurgical testicular sperm extraction in familial idiopathic nonobstructive azoospermia

et al. 2014

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The aim of the study was to evaluate the sperm retrieval rate by microsurgical testicular sperm extraction (TESE) in familial idiopathic nonobstructive azoospermia (NOA). One hundred and nineteen patients with idiopathic NOA who underwent microsurgical TESE over the past 5 years were included. Patients were then divided into two groups; Group 'A' with familial idiopathic NOA (11 families with two brothers in each family, 22 patients) and Group 'B' with nonfamilial idiopathic NOA (97 patients). Clinical data as well as data of microsurgical TESE were recorded. In Group 'A', the sperm retrieval rate was 9.1% (2/22 patients) compared to 45.4% in Group 'B' (44/97 patients) (P ≤ 0.05). The two patients in Group 'A' with successful sperm retrieval belonged to one family. The histopathological diagnosis was the same in the brothers in each family. It can be concluded that the testicular sperm retrieval rate in familial idiopathic NOA is significantly lower than in nonfamilial idiopathic NOA.

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Section: Discussionmentioning

confidence: 97%

Outcome of microsurgical testicular sperm extraction in familial idiopathic nonobstructive azoospermia

et al. 2014

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“…In another study, spermatozoa were obtained with m-TESE in 36% of the patients with nonobstructive azoospermia. [9] Vloeberghs et al [10] found sperm retrieval, and pregnancy rates related to TESE procedure as 40.5, and 37%, respectively. They determined that 13.4% of all patients who had undergone TESE had delivered healthy babies.…”

Section: Discussionmentioning

confidence: 99%

Results of intracytoplasmic sperm injection performed with sperm retrieved by microscopic testicular sperm extraction in azoospermic patients

Erdem¹,

Karacan²,

Cebi³

et al. 2018

Turkish Journal of Urology

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Objective: The absence of any sperm in the ejaculate is called azoospermia and it is detected in 1% of males and 10-15% of those with infertility complaints. Azoospermia may be due to obstructive (OA) and non-obstructive (NOA) causes. Today, healthy pregnancies can be achieved in azoospermic patients by intracytoplasmic sperm injection (ICSI) performed using sperm retrieved from microscopic testicular sperm extraction (m-TESE). In this study, we examined the sperm retrieval rates with m-TESE in azoospermic patients, the results of ICSI in OA and NOA patients with sperm and the underlying testicular pathologies in patients without sperm. Material and methods:Patients who underwent m-TESE at IVF unit of our hospital between January 2005 and April 2017 were retrospectively reviewed. A total of 342 azoospermic patients (117 OA and 225 NOA cases) with regular follow-up were included in the study. In these cases, sperm retrieval and clinical pregnancy rates after ICSI were compared.Results: Mean duration of infertility was 28.2±7.8 months in the OA group, 34.2±5.4 years in patients, 30.3±2.9 years in spouses. In the NOA group, the mean duration of infertility was 30.3±6.5 months, the mean age of the patients was 35.3±3.4, and the mean age of the spouses was 30.6±3.3 years. In 68.9% of the cases, the therapeutic indication was male factor alone, while 31.1% had female factor infertility. In the OA group, 68.9% of the cases had only male factor infertility, while 31.1% of them had also female factor infertility. In the NOA group, 65.4% of the cases had only male factor infertility, and female factor was found in 34.6% of the cases. OA patients had a mean serum FSH level of 11.7±3.7 mIU/mL and mean testicular volume of 12.5±2.6 mL, NOA patients had a mean serum FSH level of 13.7±5.4 mIU/mL and mean testicular volume of 9.8±3.4 mL. In the m-TESE procedure, motile sperm was found in all of the OA patients and in 52.4% (118/225) of the NOA patients. Clinical pregnancy rate in the OA group was 29.9% (35/117) and live birth rate was 25.6% (30/117). In the NOA group, the clinical pregnancy rate was 27.1% (32/118) and the live birth rate was 23.7% (27/118). Histopathologic evaluation was made in 107 cases in the NOA group with no testicular sperm, revealing that 59 cases with germ-cell aplasia (sertoli-cell only syndrome), 42 cases with maturation arrest, and 6 cases with hypospermatogenesis. Postoperative hematoma developed in 3 of m-TESE cases and subsided with conservative treatment. Conclusion:If motile sperm is retrieved with m-TESE application in azoospermic patients, pregnancy resulting in one live birth in about 4 couples who undergo ICSI application can be achieved. In the presence of motile sperm, live birth rates are similar between OA and NOA case with very low complication rates.

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“…In the study of Bonarriba et al [23] recently, micro TESE was applied to total 74 patients with azoospermia. Sperm was detected in 36% of these patients.…”

Section: Discussionmentioning

confidence: 99%

Do body mass index, hormone profile and testicular volume effect sperm retrieval rates of microsurgical sperm extraction in the patients with nonobstructive azoospermia?

Karamazak

Kızılay

Bahçeci

et al. 2018

Turkish Journal of Urology

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Objective: In our study, we aimed to evaluate the effect of body mass index (BMI), follicle stimulating hormone (FSH), and luteinizing hormone (LH) levels and the mean testicular volume on sperm retrieval rates in microsurgical sperm extraction (MicroTESE) in the patients with nonobstructive azoospermia (NOA). Material and methods:The data of 282 infertile patients with NOA were analysed retrospectively. The patients with normal karyotype and no Y microdeletions were included in the study. The patients were classified according to their BMI scores and the medical history, physical examination and hormonal parameters were evaluated. The overall data were processed statistically with chi-square and logistic regression analysis and the relation between preoperative findings and sperm retrieval rates was investigated. Results:The sperm retrieval rate of 282 patients after microTESE was found as 41.1%. There was no statistically significant difference in sperm retrieval rates among the subgroups classified according to BMI. FSH and LH levels and the mean testicular volume and pathologic findings were significantly correlated with sperm retrieval rates. Conclusion:Finally significant correlation was determined between sperm retrieval rates and FSH, and LH levels and testicular volumes but no statistically significant difference was found in sperm retrieval rates among BMI groups.Keywords: Body mass index; follicle stimulating hormone; luteinizing hormone; nonobstructive azoospermia; sperm retrieval.Cite this article as: Karamazak S, Kızılay F, Bahçeci T, Semerci B. Do body mass index, hormone profile and testicular volume effect sperm retrieval rates of microsurgical sperm extraction in the patients with nonobstructive azoospermia? Turk J Urol 2017; XXXXX Do body mass index, hormone profile and testicular volume effect sperm retrieval rates of microsurgical sperm extraction in the patients with nonobstructive azoospermia? IntroductionAzoospermia is defined as detection of no spermatozoa after semen samples were properly centrifuged and examined under microscope.[1] Azoospermia is found in 1% of all men and this rate rises to 15% in infertile men.[2] Distinction between obstructive and nonobstructive azoospermia should be made in all patients whose semen analysis revealed azoospermia.Patients with azoospermia should be evaluated firstly with detailed history, physical examination (especially the status of the vas deferens and testicular size) and hormone profile to differentiate between obstructive and nonobstructive azoospermia, because treatment protocols of these two pathologies are different.[3] Congenital bilateral absence of vas deferens (CBAVD) is a common cause of obstructive azoospermia. The diagnosis of CBAVD is based on physical examination where vas deferens are not palpated bilaterally on physical examination.[4] Patients with small testicular volumes have primary or secondary testicular failure. Serum hormone tests including testosterone, luteinizing hormone (LH), follicle stimulating hormone (FSH...

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Predictive factors of successful sperm retrieval in azoospermia

Cited by 14 publications

References 28 publications

Outcome of microsurgical testicular sperm extraction in familial idiopathic nonobstructive azoospermia

Outcome of microsurgical testicular sperm extraction in familial idiopathic nonobstructive azoospermia

Results of intracytoplasmic sperm injection performed with sperm retrieved by microscopic testicular sperm extraction in azoospermic patients

Do body mass index, hormone profile and testicular volume effect sperm retrieval rates of microsurgical sperm extraction in the patients with nonobstructive azoospermia?

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