Predictive medicine: towards a multi-parametric imaging for a personal risk stratification

Guedj, Éric; Cammilleri, Serge; Verger, Antoine

doi:10.1007/s00259-016-3522-2

Cited by 5 publications

(3 citation statements)

References 26 publications

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“…A total of 5 highly suspected or confirmed COVID-19 cases explored with 18 F-FDG PET have been so far described by Qin et al [1] and Zou and Zhu [2], at the diagnostic step, showing lung hypermetabolic pulmonary ground glass opacities with low-dose CT correspondence, frequently associated to lymph nodes hypermetabolism. More broadly, Deng et al [3] also argue for the possible 18 F-FDG PET utility, as a sensitive tool to detect and monitor inflammatory diseases, such as viral pneumonia, monitor disease progression, and treatment outcomes, according to the major goals of precision medicine in which PET imaging is well-known to be crucially involved [4]. On the opposite, Joob and Wiwanitkit have recalled that 18 F-FDG PET is still not recommended in infectious pneumonia, and especially warned of the risk of disease spreading in PET departments [5].…”

mentioning

confidence: 99%

PET imaging of COVID-19: the target and the number

Guedj

Verger

Cammilleri

2020

Eur J Nucl Med Mol Imaging

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confidence: 99%

PET imaging of COVID-19: the target and the number

Guedj

Verger

Cammilleri

2020

Eur J Nucl Med Mol Imaging

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“…This fact has suggested the insight that [ 18 F]FDG PET/CT may be a potential imaging tool for COVID-19. The study of Deng et al who have also argued for the possible [ 18 F]FDG PET/CT utility, as a sensitive tool to detect and monitor inflammatory diseases, such as viral pneumonia, its progression, and treatment outcomes moves in this direction [ 203 , 204 ].…”

Section: Resultsmentioning

confidence: 99%

State of the art of 18F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation

Casali

Lauri

Altini

et al. 2021

Clin Transl Imaging

103

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Aim The diagnosis, severity and extent of a sterile inflammation or a septic infection could be challenging since there is not one single test able to achieve an accurate diagnosis. The clinical use of 18F-fluorodeoxyglucose ([ 18 F]FDG) positron emission tomography/computed tomography (PET/CT) imaging in the assessment of inflammation and infection is increasing worldwide. The purpose of this paper is to achieve an Italian consensus document on [ 18 F]FDG PET/CT or PET/MRI in inflammatory and infectious diseases, such as osteomyelitis (OM), prosthetic joint infections (PJI), infective endocarditis (IE), prosthetic valve endocarditis (PVE), cardiac implantable electronic device infections (CIEDI), systemic and cardiac sarcoidosis (SS/CS), diabetic foot (DF), fungal infections (FI), tuberculosis (TBC), fever and inflammation of unknown origin (FUO/IUO), pediatric infections (PI), inflammatory bowel diseases (IBD), spine infections (SI), vascular graft infections (VGI), large vessel vasculitis (LVV), retroperitoneal fibrosis (RF) and COVID-19 infections. Methods In September 2020, the inflammatory and infectious diseases focus group (IIFG) of the Italian Association of Nuclear Medicine (AIMN) proposed to realize a procedural paper about the clinical applications of [ 18 F]FDG PET/CT or PET/MRI in inflammatory and infectious diseases. The project was carried out thanks to the collaboration of 13 Italian nuclear medicine centers, with a consolidate experience in this field. With the endorsement of AIMN, IIFG contacted each center, and the pediatric diseases focus group (PDFC). IIFG provided for each team involved, a draft with essential information regarding the execution of [ 18 F]FDG PET/CT or PET/MRI scan (i.e., indications, patient preparation, standard or specific acquisition modalities, interpretation criteria, reporting methods, pitfalls and artifacts), by limiting the literature research to the last 20 years. Moreover, some clinical cases were required from each center, to underline the teaching points. Time for the collection of each report was from October to December 2020. Results Overall, we summarized 291 scientific papers and guidelines published between 1998 and 2021. Papers were divided in several sub-topics and summarized in the following paragraphs: clinical indications, image interpretation criteria, future perspectivess and new trends (for each single disease), while patient preparation, image acquisition, possible pitfalls and

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“…In addition to this technical multimodality and the concomitant efforts of using various radiopharmaceuticals to characterize multiple biological targets (61,105), currently used multiparametric imaging also integrates the development and applications of innovative methods of image processing and analysis (120). While common metrics such as standard uptake value (SUV) or BTV or TBR only partially describes the properties of pathological lesions, novel parameters such as shape and uptake heterogeneity may provide additional information on the biological profile associated with tumor aggressiveness or degree of response to specific treatment and, consequently, with prognosis (121).…”

Section: Future Perspectives: Novel Radiotracers and Multimodalitymentioning

confidence: 99%

PET Imaging in Glioblastoma: Use in Clinical Practice

Verger¹,

Langen²

2017

Glioblastoma

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Positron emission tomography (PET) is a nuclear medicine imaging method with increasing relevance for the diagnosis, prognostication, and monitoring of glioblastomas. PET provides additional insight beyond magnetic resonance imaging (MRI) into the biology of gliomas, which can be used for noninvasive grading, differential diagnosis, delineation of tumor extent, planning of surgery, and radiotherapy and post-treatment monitoring. In clinical practice, two classes of radiotracers have been used predominantly for imaging purposes, namely glucose metabolism tracers and amino acid transport tracers. Both classes of tracers can provide information on grading and prognosis of gliomas, but amino acid tracers, which exhibit lower uptake in normal brain tissue, are better suited for delineation of tumor extent, treatment planning, or follow-up than 18 F-2-fluoro-2-deoxy-D-glucose ( 18 F-FDG). Owing to the progress in PET imaging using radiolabeled amino acids in recent years, the Response Assessment in Neuro-Oncology (RANO) working group, an international effort to develop new standardized response criteria for clinical trials in brain tumors, has recently recommended amino acid PET as an additional tool in the diagnostic assessment of brain tumors. PET Imaging in Glioblastomas 156These developments as well as multimodality imaging should improve the diagnostic assessment of these tumors.

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Predictive medicine: towards a multi-parametric imaging for a personal risk stratification

Cited by 5 publications

References 26 publications

PET imaging of COVID-19: the target and the number

PET imaging of COVID-19: the target and the number

State of the art of 18F-FDG PET/CT application in inflammation and infection: a guide for image acquisition and interpretation

PET Imaging in Glioblastoma: Use in Clinical Practice

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