Predictive Prognostic Value of Tissue-Based MicroRNA Expression in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-analysis

Troiano, Giuseppe; Mastrangelo, Filiberto; Caponio, Vito Carlo Alberto; Laino, Luigi; Cirillo, Nicola; Muzio, Lorenzo Lo

doi:10.1177/0022034518762090

Cited by 66 publications

(68 citation statements)

References 41 publications

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“…Since the EMT is highly associated with drug resistance (58), it is likely that the ZBTB7A-TRAIL-R2 axis may also attenuate EMTassociated drug resistance. Since disruptions of the miR-371-miR-373 cluster and the chromosome 19q13 locus are rather common in malignancies (4,6,8,10,(12)(13)(14), genome-wide studies should help with a more comprehensive understanding of how aberrations in the miR-372-ZBTB7A-TRAIL-R2 cascade affect oncogenicity.…”

Section: Discussionmentioning

confidence: 99%

“…miR-372/miR-373 were then found to be oncogenes that target LATS2, CD44 and various other differentiation regulators active in tumors (12,13). They are upregulated in malignancies and their upregulation of expression of miR-372/miR-373 has been found in HNSCC and miR-372 expression in tumors is a prognostic marker of OSCC (6,8,14). Serum miR-372 levels are potential diagnosis and prognosis biomarkers in neoplasms including HNSCC (4,15).…”

Section: Introductionmentioning

confidence: 99%

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The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma

Yeh¹,

Yang

Wu³

et al. 2020

Front. Oncol.

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miR-372 has been shown a potent oncogenic miRNA in the pathogenesis of oral squamous cell carcinoma (OSCC). The zinc finger and BTB domain containing 7A protein (ZBTB7A) is a transcriptional regulator that is involved in a great diversity of physiological and oncogenic regulation. However, the modulation of ZBTB7A in OSCC remains unclear. Tissue analysis identifies a reverse correlation in expression between miR-372 and ZBTB7A in OSCC tumors. When OSCC cells have stable knockdown of ZBTB7A, their oncogenic potential and drug resistance is increased. By way of contrast, such an increase is attenuated by expression of ZBTB7A. Screening and validation confirms that ZBTB7A is able to modulate expression of the death receptors TRAIL-R1, TRAIL-R2, Fas and p53 phosphorylated at serine-15. In addition, ZBTB7A transactivates TRAIL-R2, which sensitizes cells to cisplatin-induced apoptosis. The ZBTB7A-TRAIL-R2 cascade is involved in both the extrinsic and intrinsic cisplatin-induced pathways of apoptosis. Database analysis indicates that the expression level of and the copy status of ZBTB7A and TRAIL-R2 are important survival predictors for head and neck cancers. Collectively, this study indicates the importance of the miR-372-ZBTB7A-TRAIL-R2 axis in mediating OSCC pathogenesis and in controlling OSCC drug resistance. Therefore, silencing miR-372 and/or upregulating ZBTB7A would seem to be promising strategies for enhancing the sensitivity of OSCC to cisplatin therapy.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma

Yeh¹,

Yang

Wu³

et al. 2020

Front. Oncol.

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“…After integration into the RNA-induced silencing complex (RISC), the mature miRNA regulates the target gene mRNA expression [6]. Recently, meta-analyses have revealed that the upregulation of 9 miRNAs ( miR-21 , miR-455-5p , miR-155-5p , miR-372 , miR-373 , miR-29b , miR-1246 , miR-196a , and miR-181 ) and the downregulation of 7 miRNAs ( miR-204 , miR-101 , miR-32 , miR-20a , miR-16 , miR-17 , and miR-125b ) are strongly correlated with poor prognosis in OSCC patients [83]. Long noncoding RNA (lncRNA), a class of non-protein coding transcripts longer than 200 nucleotides, is also associated with gene expression and cancer progression [84].…”

Section: Novel Prognosticators Of Osccmentioning

confidence: 99%

Hallmarks of Cancer-Related Newly Prognostic Factors of Oral Squamous Cell Carcinoma

Sasahira

Kirita

2018

IJMS

217

184

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Head and neck cancer, including oral squamous cell carcinoma (OSCC), is the sixth leading malignancy worldwide. OSCC is an aggressive tumor and its prognosis has exhibited little improvement in the last three decades. Comprehensive elucidation of OSCC’s molecular mechanism is imperative for early detection and treatment, improving patient survival. Based on broadly accepted notions, OSCC arises from multiple genetic alterations caused by chronic exposure to carcinogens. In 2011, research revealed 10 key alterations fundamental to cancer cell development: sustaining proliferative signaling, evading growth suppressors, avoiding immune destruction, activating invasion and metastasis, tumor-promoting inflammation, enabling replicative immortality, inducing angiogenesis, genome instability and mutation, resisting cell death, and deregulating energetics. This review describes molecular pathological findings on conventional and novel hallmarks of OSCC prognostic factors. In addition, the review summarizes the functions and roles of several molecules as novel OSCC prognosticators.

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“…A recent systematic review and meta-analysis has revealed that downregulation of miR-204 was correlated with poor prognosis in OSCC [69]. In other cancer types, it appears miR-204 also serves as a tumor suppressor.…”

Section: Microrna-204mentioning

confidence: 99%

MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells

Hsieh

Liao

Pichler

et al. 2020

Cancers

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Oral cancer belongs to head and neck squamous cell carcinoma and has been recognized as one of the most prevalent malignancies worldwide. Recent studies have suggested that cancer stem cells (CSCs) may participate in tumor initiation, metastasis and even recurrence, so the regulation of CSCs has drawn significant attention over the past decade. Among various molecules that are associated with CSCs, non-coding RNAs (ncRNAs) have been indicated as key players in the acquisition and maintenance of cancer stemness. In addition, accumulating studies have shown that the aberrant expression of these ncRNAs may serve as surrogate diagnostic markers or even therapeutic targets for cancer treatment. The current study reviews the previous work by us and others to summarize how these ncRNAs affect oral cancer stemness and their potential theranostic applications. A better understanding of the implication of these ncRNAs in oral tumorigenesis will facilitate the translation of basic ncRNA research into clinical application in the future.

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Predictive Prognostic Value of Tissue-Based MicroRNA Expression in Oral Squamous Cell Carcinoma: A Systematic Review and Meta-analysis

Cited by 66 publications

References 41 publications

The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma

The miR-372-ZBTB7A Oncogenic Axis Suppresses TRAIL-R2 Associated Drug Sensitivity in Oral Carcinoma

Hallmarks of Cancer-Related Newly Prognostic Factors of Oral Squamous Cell Carcinoma

MicroRNAs as Theranostics Targets in Oral Carcinoma Stem Cells

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