Predictive Roles of Proteomic Profiles in Assisted Reproduction-An Update

Abstract

Proteomics is the study of the expression, localization, functions, post-translational modifications and interactions of proteins that are expressed by a genome at a specific condition and at a specific time. Proteomics identifies differentially expressed proteins utilizing robust techniques and search engines and data bases, quantifies their presence and also highlights the proteins that could serve as potential candidates by validation studies. Hence, proteomics provides us with information regarding the functionality of the cell as they represent proteins are the functional units of the cell [4]. They drive every cellular process after being transcribed, translated, and modified from their genomic origin. There are over 200 post-translational modifications, including splicing, glycosylation, phosphorylation, acetylation, etc. [5]. Due to post-translational modifications, multiple proteins can be derived from a single polypeptide which originates from a single, parent mRNA transcript, and hence, from the gene. Thus, the level of