Predictive significance for sudden death of microvolt-level T wave alternans in New York Heart Association class II congestive heart failure patients

Is Microvolt T-Wave Alternans the Answer to Risk Stratification in Heart Failure?

“…An additional 17 patients were excluded after indeterminate MTWA testing, leaving a small and highly selected group in which a positive MTWA test was associated with an increased risk of VTE over 17 months. 29 In another study, of 46 patients with New York Heart Association II/III CHF, MTWA predicted cardiac death (nϭ7) but not SCD (nϭ1). 30 In the third study, of 107 patients with CHF, none of the 13 end points occurred in MTWA-negative patients and MTWA was the only independent predictor of VTE.…”

Combined prognostic value of peak O2 uptake and microvolt level T-wave alternans in patients with idiopathic dilated cardiomyopathy

“…The results of several studies [15][16][17][18][19][20][21][22]30,31] demonstrated that MTWA is a promising predictor of SCD or major arrhythmic events in patients with DCM.…”

“…In a previous study, we investigated the role of MTWA in patients with cardiomyopathies of different etiologies, good functional status (NYHA class II) and low-tomoderate LVEF impairment (LVEF 36 ± 7%) [30]. During the two years follow-up 8 arrhythmic events occurred in patients with abnormal MTWA, while no event occurred in negative MTWA subgroup.…”

Epidemiological impact of microvolt T-wave alternans in sudden cardiac death primary prevention

“…Baravelli et al [1] in a recent issue reported the results of an observational analysis of patients with documented LVEF b 45% and New York Heart Association (NYHA) functional class II undergoing Microvolt T-Wave Alternans (MTWA) testing, and the incidence of sudden cardiac death.…”

“…Baravelli et al [1] explored an intriguing subset of patients that according the current guidelines may not qualify for an ICD implantation. This includes patients with an EF between 35% and 45% and NYHA class II.…”