Predictive Value of Associations Between Carotid Arterial Sclerosis and Left Ventricular Diastolic Dysfunction in Patients with Cardiovascular Risk Factors

Mizuguchi, Yukio; Tanaka, Hideji; Oishi, Yoshifumi; Miyoshi, Hirokazu; Emi, Shigefumi; Ishimoto, Takuya; Nagase, Norio; Oki, Takashi

doi:10.1016/j.echo.2007.01.006

Cited by 27 publications

(22 citation statements)

References 37 publications

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“…In the present study, the odds ratio in the High Stiffness group was comparable to that in the High IMT group; however, the combination of IMT and stiffness parameter was found to yield a higher predictive value for concurrent CAD than either index alone. It is also reported that increased arterial stiffness may decrease diastolic pressure, and subsequently coronary artery blood flow, even in the absence of coronary artery stenosis 30,31) . This impact of arterial stiffness on myocardial function independent of atherotic change may explain the high association of the combination of two indexes.…”

Section: Discussionmentioning

confidence: 99%

“…There have been fewer studies of the clinical implications of stiffness parameter than of IMT. We and several other investigators have reported that stiffness parameter is associated with left ventricular function 30,31) , insulin resistance 22,23,32,33) , peripheral artery disease 21) , decreased GFR 20) , and drug treatments 15, 24-26, 34, 35) . These findings suggest the possible use of stiffness parameter as both a surrogate marker of atherosclerosis in treatment and a predictor of CAD.…”

Section: Discussionmentioning

confidence: 99%

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The Combination of IMT and Stiffness Parameter .BETA. is Highly Associated with Concurrent Coronary Artery Disease in Type 2 Diabetes

Lee

Emoto

Teramura

et al. 2009

JAT

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Aims:The clinical implications of stiffness of the carotid artery (CA) have not been fully clarified in the prediction of coronary artery disease (CAD), although intima-media thickness (IMT) has been established as a surrogate marker. We examined the associations of stiffness parameter (ST) and IMT with concurrent CAD. Methods: IMT and ST were measured by ultrasound in 439 nondiabetic subjects as a control and 1528 type 2 diabetic subjects (T2DM) with or without CAD in a cross-sectional study.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Combination of IMT and Stiffness Parameter .BETA. is Highly Associated with Concurrent Coronary Artery Disease in Type 2 Diabetes

Lee

Emoto

Teramura

et al. 2009

JAT

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“…We found no association between E/A ratios and IMT in our population. Previous Western studies in hypertensive patients and with small sample size have shown that carotid IMT was associated with markers of diastolic function [29][30][31][32][33] such as isovolumic relaxation time and DT. However, data on the relationship between E/A ratio and carotid IMT were scarce, with only one Japanese study reported an unadjusted insignificant association.…”

Section: Arterial Stiffness and Left-ventricular Diastolic Dysfunctiomentioning

confidence: 99%

Arterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD

Jiang

Lam

et al. 2010

J Hum Hypertens

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Brachial-ankle pulse wave velocity (baPWV), a marker of arterial stiffness, is an established cardiovascular risk factor of ventricular stiffening. We studied the association of baPWV with left-ventricular (LV) diastolic function in a sub-study of the Guangzhou Biobank Cohort Study. In all, 378 Chinese subjects with a normal ejection fraction (450%) had baPWV measurement by a noninvasive automatic waveform analyser, carotid intima-medial thickness (IMT) measurement by B-mode ultrasonography and cardiac diastolic function assessment by echocardiography. After adjusting for age, both baPWV and IMT were associated with LV mass index, posterior wall end-diastolic thickness and inter-ventricular end-diastolic thickness, but only baPWV was associated with deceleration time, atrial flow velocity and E/A ratio. Multivariable linear regression model showed that baPWV and mean arterial pressure, but not IMT, were significantly associated with E/A ratio (b ¼ À0.02, P ¼ 0.03 and b ¼ À0.36, P ¼ 0.02, respectively). The receiver operator characteristic curve showed that baPWV was better than pulse pressure or mean arterial pressure to detect LV diastolic dysfunction (E/Ao1.0). Our study suggested that increased baPWV might be an independent risk factor or marker for diastolic dysfunction. Early detection of an intervention on increased baPWV may be important for prevention of cardiac diastolic dysfunction.

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“…Elastic modulus, distensibility, and stiffness index β are the methods used for a local assessment of arterial stiffness 33, 34. However, validity and reproducibility of these methods are limited because of their dependence on the patient's blood pressure 7, 9.…”

Section: Discussionmentioning

confidence: 99%

Ascending Aortic Strain Analysis Using 2‐Dimensional Speckle Tracking Echocardiography Improves the Diagnostics for Coronary Artery Stenosis in Patients With Suspected Stable Angina Pectoris

Fan

et al. 2018

JAHA

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BackgroundArterial stiffening and atherosclerosis tend to coexist. Strain imaging, using a 2‐dimensional speckle tracking (2D‐ST) method, has been used for arterial stiffness assessment and early identification of atherosclerosis. We investigated whether the ascending aortic strain assessed by 2D‐ST echocardiography at rest can predict the presence of coronary artery disease (CAD).Methods and ResultsTwo hundred seventy‐one consecutive patients with suspected stable angina pectoris sequentially underwent exercise treadmill testing, 2‐dimensional echocardiography, M‐mode echocardiography, 2D‐ST echocardiography, and coronary angiography. Circumferential ascending aortic strain (CAAS) and radial ascending aortic strain were assessed by 2D‐ST echocardiography. Ninety‐two patients with coronary lumen area stenosis ≥70% were categorized as having significant CAD. Global CAAS was significantly lower in patients with significant CAD (7.41±2.30% versus 11.54±4.03%; P<0.001) and remained an independent predictor of significant CAD (odds ratio, 0.64 [0.54–0.75]; P<0.001) after multivariate regression. Based on the receiver operating characteristic curve for diagnosing significant CAD, the optimal cut‐off value of global CAAS was ≤9.22% (sensitivity, 86%; specificity, 70%; area under curve=0.82; P<0.001). Global CAAS decreased with increasing severity of CAD and was significantly associated with 3‐vessel disease (odds ratio, 0.58 [0.42–0.79]; P<0.001). Diagnostics for significant CAD were remarkably better for global CAAS combined with exercise treadmill testing than for exercise treadmill testing alone (area under curve=0.88 versus 0.78; P<0.001).ConclusionsGlobal CAAS assessed by 2D‐ST echocardiography at rest was able to predict the presence of significant CAD and identify multivessel disease. In addition, global CAAS combined with exercise treadmill testing remarkably improved the diagnostics for significant CAD.

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Predictive Value of Associations Between Carotid Arterial Sclerosis and Left Ventricular Diastolic Dysfunction in Patients with Cardiovascular Risk Factors

Cited by 27 publications

References 37 publications

The Combination of IMT and Stiffness Parameter .BETA. is Highly Associated with Concurrent Coronary Artery Disease in Type 2 Diabetes

The Combination of IMT and Stiffness Parameter .BETA. is Highly Associated with Concurrent Coronary Artery Disease in Type 2 Diabetes

Arterial stiffness and left-ventricular diastolic dysfunction: Guangzhou Biobank Cohort Study-CVD

Ascending Aortic Strain Analysis Using 2‐Dimensional Speckle Tracking Echocardiography Improves the Diagnostics for Coronary Artery Stenosis in Patients With Suspected Stable Angina Pectoris

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