Predictive Value of Banff Score of Early Kidney Allograft Biopsies for 1-Year Graft Survival

Kamińska, Dorota; Bernat, B; Mazanowska, Oktawia; Krasnowski, R; Polak, Wojciech; Patrzałek, D.; Kochman, Agata; Klinger, Marian

doi:10.1016/j.transproceed.2005.12.027

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…This can mainly be attributed to the uncertainty about its pathogenetic basis and prognostic impact. Some investigators suggested an unfavorable impact on outcome (14,15), which, however, could not be confirmed by other studies (16,17). These controversial results might indicate a heterogeneous pathogenesis of the lesion.…”

Section: Monocytes In Humoral Rejectionmentioning

confidence: 89%

The Cellular Lesion of Humoral Rejection: Predominant Recruitment of Monocytes to Peritubular and Glomerular Capillaries

Fahim

Böhmig²,

Exner³

et al. 2007

American Journal of Transplantation

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Accumulation of inflammatory cells within capillaries is a common morphologic feature of humoral renal allograft rejection and is most easily appreciated if it occurs in glomeruli. The aim of our study was to determine the amount and composition of immune cells within glomeruli and peritubular capillaries (PTC) in cellular and humoral allograft rejection. Immunofluorescent double-labeling for CD31 and CD3 or CD68 was used for phenotyping and enumerating immune cells within glomeruli and PTC. The major findings are: (1) accumulation of immune cells in PTC is far more common than it would be anticipated based on the assessment by conventional histology; (2) it is not the absolute number of immune cells accumulating within capillaries, but rather the composition of the intracapillary cell population that distinguishes humoral rejection from cellular rejection and (3) in C4d positive biopsies a predominantly monocytic cell population accumulates not only within glomeruli but also within PTC. The median value of monocyte/T-cell ratio within PTC was 2.3 in C4d positive biopsies but only 1 (p = 0.0008) in C4d negative biopsies. Given their prominent presence within capillaries and their extensive biological versatility monocytes might contribute to the capillary damage observed in acute and chronic allograft rejection.

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Section: Monocytes In Humoral Rejectionmentioning

confidence: 89%

The Cellular Lesion of Humoral Rejection: Predominant Recruitment of Monocytes to Peritubular and Glomerular Capillaries

Fahim

Böhmig²,

Exner³

et al. 2007

American Journal of Transplantation

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“…Renal transplant biopsies are evaluated according to the Banff scoring system since it was shown that a high Banff score is predictive for the graft survival [13]. …”

Section: Discussionmentioning

confidence: 99%

Correlation of histopathologic and dynamic tissue perfusion measurement findings in transplanted kidneys

et al. 2013

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BackgroundCortical perfusion of the renal transplant can be non-invasively assessed by color Doppler ultrasonography. We performed the Dynamic Tissue Perfusion Measurement (DTPM) of the transplant’s renal cortex using color Doppler ultrasonography (PixelFlux technique), and compared the results with the histopathological findings of transplant biopsies.MethodsNinety-six DTPM studies of the renal transplant’s cortex followed by transplant biopsies were performed in 78 patients. The cortical perfusion data were compared with the parameter of peritubular inflammatory cell accumulation (PTC 0 to 3) based on Banff-classification system.ResultsA significant decrease of cortical perfusion could be demonstrated as the inflammatory cells accumulation in peritubular capillaries increased. Increasing peritubulitis caused a perfusion loss from central to distal layers of 79% in PTC 0, of 85% in PTC 1, of 94% in PTC 2, and of 94% in PTC 3. Furthermore, the perfusion loss due to peritubular inflammation was more prominent in the distal cortical layer. The extent of perfusion decline with increasing peritubulitis (from PTC 0 to PTC 3) was 64% in proximal 20% cortical layer (p20), 63% in proximal 50% cortical layer (p50), increased to 76% in distal 50% cortical layer (d50), and peaked at 90% in the distal 20% cortical layer (d20). For those without peritubulitis (PTC 0), the increase in the the Interstitial Fibrosis/Tubular Atrophy (IF/TA) score was accompanied by a significantly increased cortical perfusion. A Polyomavirus infection was associated with an increased cortical perfusion.ConclusionsOur study demonstrated that the perfusion of the renal transplant is associated with certain pathological changes within the graft. DTPM showed a significant reduction of cortical perfusion in the transplant renal cortex related to peritubular capillary inflammation.

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Induction of Tolerance in Renal Transplantation Using Splenic Transplantation: Experimental Study in a Canine Model

Ayala-García

Soel

Díaz

et al. 2010

Transplantation Proceedings

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Predictive Value of Banff Score of Early Kidney Allograft Biopsies for 1-Year Graft Survival

Cited by 5 publications

References 10 publications

The Cellular Lesion of Humoral Rejection: Predominant Recruitment of Monocytes to Peritubular and Glomerular Capillaries

The Cellular Lesion of Humoral Rejection: Predominant Recruitment of Monocytes to Peritubular and Glomerular Capillaries

Correlation of histopathologic and dynamic tissue perfusion measurement findings in transplanted kidneys

Induction of Tolerance in Renal Transplantation Using Splenic Transplantation: Experimental Study in a Canine Model

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