Predictive value of cystatin C and beta-2 microglobulin in preeclampsia

Farag, Mona K.; Maksoud, Nabila Abd El; Ragab, Halla M.; Gaber, Khaled R.

doi:10.1016/j.jgeb.2011.09.003

Cited by 6 publications

(6 citation statements)

References 28 publications

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“…A possible predictive value of cystatin C in preeclampsia was highlighted in a recent study by Farag et al (29). The authors showed the significantly elevated levels of cystatin C and beta 2 microglobulin in women who were in the second trimester of pregnancy and subsequently developed preeclampsia compared with healthy pregnant women (29). Oxidative stress and maternal endothelial dysfunction due to placental ischemia might be detected before the onset of PE; thus, combining oxidative stress markers and cystatin C with other markers in early periods of pregnancy to evaluate the predictive value in preeclampsia might be in scope of future studies.…”

Section: Table Demographic Laboratory and Clinical Characteristics mentioning

confidence: 91%

“…Early prediction of PE is imperative for improving the maternal and fetal consequences. A possible predictive value of cystatin C in preeclampsia was highlighted in a recent study by Farag et al (29). The authors showed the significantly elevated levels of cystatin C and beta 2 microglobulin in women who were in the second trimester of pregnancy and subsequently developed preeclampsia compared with healthy pregnant women (29).…”

Section: Table Demographic Laboratory and Clinical Characteristics mentioning

confidence: 98%

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Relationship Between Oxidative Stress Parameters and Cystatin C Levels in Patients With Severe Preeclampsia

et al. 2013

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Background and Objective. Oxidative stress is believed to play a role in the development of preeclampsia (PE). It is known that an increased cystatin C level is also associated with PE. The aim of this study was to investigate the relationship between oxidative stress parameters and cystatin C levels in patients with severe PE. Material and Methods. Forty-four patients with severe PE and 40 healthy pregnant women were recruited for the study. All study subjects were divided into 2 groups: group 1 (n=44) consisted of patients with severe PE, and group 2 (n=40) included healthy pregnant subjects. Blood samples were obtained from all subjects in order to measure the cystatin C level, total antioxidant status, and total oxidant status. The oxidative stress index was calculated. Results. The group 1 had significantly higher cystatin C, total oxidant status, oxidative stress index levels and lower total antioxidant status level as compared with the group 2 (P=0.001, P<0.001, P<0.001, P=0.036, respectively). The serum cystatin C level was significantly correlated with the oxidative stress index (r=0.609, P<0.001). Conclusions. The present study demonstrated that both oxidative stress and cystatin C levels were increased in patients with PE, and the increased cystatin C levels seem to be a consequence of oxidative stress. Correspondence to

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Section: Table Demographic Laboratory and Clinical Characteristics mentioning

confidence: 91%

Section: Table Demographic Laboratory and Clinical Characteristics mentioning

confidence: 98%

Relationship Between Oxidative Stress Parameters and Cystatin C Levels in Patients With Severe Preeclampsia

et al. 2013

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“…[24][59][60] [61] Cell-free foetal DNA, p-selectin (before 20 weeks), pentraxin 3 (all trimesters), free foetal Hb F, the antiplasmin alpha 2-microglobulin, cystatin -C and beta-2 microglobulin, maternal serum netrin-I are increased while pregnancy-associated plasma protein A (PAPP-A), placental protein-13…”

Section: The Immune-inflammatory Cascadementioning

confidence: 99%

Adjunctive Use of Esomeprazole in the Treatment of Pre-Eclampsia: A Case Report and Literature Review

Oriaifo¹

2017

WJPPS

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Faced with the absence of suitable assays and/or kits for predictive biomarkers, medical practitioners in poor resource settings may be emasculated by the unrelenting upwards prevalence of and uncertain forecast associated with the pre-eclampsia/eclampsia and fetal growth restriction disease spectrum. Low-birth weight and pre-eclampsia due to placental malaria, multiple pregnancy and malnutrition may be reactive oxygen species -and anti-angiogenic factors -dependent.Adjunctive esomeprazole promises to be a treatment regimen that may lead to cure for it has been found to attenuate the known pathophysiologic mechanisms responsible for pre-eclampsia and IUGR which may be imbalance between pro-angiogenic and anti-angiogenic factors. The proton pump inhibitor, esomeprazole, decreases the excessive secretion of the anti-angiogenic factors soluble fmslike tyrosine kinase-I (sFlt-I) and soluble endoglin from the placenta responsible for the hypertension, endothelial dysfunction, multiorgan injury and foetal growth restriction in preeclampsia. sFlt-I binds the pro-angiogenic placenta growth factor (PIGF) and vascular endothelial growth factor (VEGF), the circulating free forms of which are low in preeclampsia. Case report is of a 32-year old Nigerian housewife who showed significant reduction in blood pressure, proteinuria and pedal oedema with esomeprazole add-on to a regimen of methyl-dopa for severe preeclampsia. The combination significantly (P < 0.05) This report corroborates the accumulating pre-clinical data on the safety and efficacy of esomeprazole in the treatment of preeclampsia, a precursor of eclampsia.

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“…From the above explan-ation, the serum cystatin C has superior diagnostic accuracy as a marker of glomerular endoteliosis or renal involvement in preeclampsia compared to creatin-ine. 4,11,12 Studies conducted Franceschini et al (2008) and Mona Faraq et al (2011) found that cystatin C levels rise higher in patients with preeclampsia compared than in normotensive pregnancy.Helena Strevens et al (2002) compared the levels of cystatin C, creatinine and uric acid. Cystatin C has superior diagnostic accuracy for preeclampsia compared with serum uric acid or creatinine.…”

Section: Introductionmentioning

confidence: 99%

“…Cystatin C has superior diagnostic accuracy for preeclampsia compared with serum uric acid or creatinine. [11][12][13] Incidence of perinatal morbidity and mortality is rising in pregnancy with preeclampsia, and this is mainly due to preterm labor and uteroplacental insufficiency, which results in decreased blood flow to the fetus. Prematurity, fetal growth retardation (IUGR), and fetal death (IUFD) are neonatal complications that should be well-anticipated in patients with preeclampsia.…”

Section: Introductionmentioning

confidence: 99%

The comparison of creatinine and cystatin C value in preeclampsia severity and neonatal outcome

Wantania

Winarto

2018

MOG

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Objectives: to compare the levels of creatinine and cystatin C with the severity of preeclampsia, and assess neonatal outcomes.Materials and Methods: Creatinine, cystatin C, and neonatal outcomes were assesed in 17 normotensive samples, 17 samples of mild preeclampsia and 17 samples of severe preeclampsia. Analysis of data with statistical tests of ANOVA and t test differences between 2 proportions.Results: The mean levels of creatinine in the normotensive group, mild preeclampsia, severe preeclampsia are 0.56 mg/dL, 0.67 mg/ dL, and 0.75 mg/dL, p=0.138; While on cystatin C are 0.82 mg/L, 1.03 mg/L and 1.32 mg/L, p=0.000. The adverse neonatal out-come wasn’t found in the normotensive group. In mild pre-eclampsia obtained 1 preterm birth and 1 intrauterine fetal death (IUFD), whereas in severe preeclampsia obtained 3 babies born preterm, 1 IUFD, and 1 intrauterine growth restriction (IUGR).Conclusion: levels of cystatin C was increased significantly in line with increased severity of preeclampsia, whereas creatinine was not increased significantly. Cystatin C is better than crea-tinine as a marker of renal dysfunction in preeclampsia patients. There was an increase in adverse neonatal outcomes in the group of preeclampsia.

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Predictive value of cystatin C and beta-2 microglobulin in preeclampsia

Cited by 6 publications

References 28 publications

Relationship Between Oxidative Stress Parameters and Cystatin C Levels in Patients With Severe Preeclampsia

Relationship Between Oxidative Stress Parameters and Cystatin C Levels in Patients With Severe Preeclampsia

Adjunctive Use of Esomeprazole in the Treatment of Pre-Eclampsia: A Case Report and Literature Review

The comparison of creatinine and cystatin C value in preeclampsia severity and neonatal outcome

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