Predictive Value of Estimated Lean Body Mass for Neurological Outcomes after Out-of-Hospital Cardiac Arrest

Lee, Sung Eun; Kim, Hyuk-Hoon; Chae, Minjung Kathy; Park, Eun-jung; Choi, Sangchun

doi:10.3390/jcm10010071

Cited by 2 publications

(1 citation statement)

References 32 publications

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“…Sample size was calculated based on data of the association between lean body mass (weight of the entire body excluding fat component) and the outcome of OHCA patients [ 16 ]. In this study, a lean body mass ≥48.98 kg was associated with a good neurologic outcome after cardiac arrest, and the proportion of patients with a lean body mass ≥48.98 kg in the two groups according to the neurologic outcome was 58.6% and 23.5%, respectively.…”

Section: Methodsmentioning

confidence: 99%

Lower limb muscle matters in patients with hypoxic brain injury following out-of-hospital cardiac arrest

Jang¹,

Park²,

Lee³

et al. 2023

ACC

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Background: There are conflicting results regarding the association between body mass index and the prognosis of cardiac arrest patients. We investigated the association of the composition and distribution of muscle and fat with neurologic outcomes at hospital discharge in successfully resuscitated out-of-hospital cardiac arrest (OHCA) patients.Methods: This prospective, single-centre, observational study involved adult OHCA patients, conducted between April 2019 and June 2021. The ratio of total skeletal muscle, upper limb muscle, lower limb muscle, and total fat to body weight was measured using InBody S10, a bioimpedance analyser, after achieving the return of spontaneous circulation. Restricted cubic spline curves with four knots were used to examine the relationship between total skeletal muscle, upper limb muscle, and lower limb muscle relative to total body weight and neurologic outcome at discharge. Multivariable logistic regression analysis was performed to assess an independent association.Results: A total of 66 patients were enrolled in the study. The proportion of total muscle and lower limb muscle positively correlated with the possibility of having a good neurologic outcome. The proportion of lower limb muscle showed an independent association in the multivariable analysis (adjusted odds ratio, 2.29; 95% confidence interval, 1.06–13.98), and its optimal cut-off value calculated through receiver operating characteristic curve analysis was 23.1%, which can predict a good neurological outcome. Conclusions: A higher proportion of lower limb muscle to body weight was independently associated with the probability of having a good neurologic outcome in OHCA patients.

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Section: Methodsmentioning

confidence: 99%

Lower limb muscle matters in patients with hypoxic brain injury following out-of-hospital cardiac arrest

Jang¹,

Park²,

Lee³

et al. 2023

ACC

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Should paediatric chest compression depth targets consider body habitus? – A chest computed tomography imaging study

et al. 2022

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Aim This study explored how body habitus in the paediatric population might potentially affect the use of one-third external anterior-posterior (APD) diameter when compared to age-appropriate absolute chest compression depth targets. It also explored how body habitus could potentially affect the relationship between one-third external and internal APD (compressible space) and if body habitus indices were independent predictors of internal APD at the lower half of the sternum. Methods This was a secondary analysis of a retrospective study of chest computed tomography (CT) scans of infants and children (>24-hours-of-life to less-than-18-years-old) from 2005 to 2017. Patients’ scan images were reviewed for internal and external APDs at the mid-point of the lower half of the sternum. Body habitus and epidemiological data were extracted from the electronic medical records. Results Chest CT scans of 193 infants and 398 children were evaluated. There was poor concordance between one-third external APD measurements and age-specific absolute chest compression depth targets, especially in infants and overweight/obese adolescents. There was a co-dependent relationship between one-third external APD and internal APD measurements. Overweight/obese children’s and adolescents’ internal and external APDs were significant different from the normal/underweight groups. Body-mass-index (BMI) of children and adolescents (p = 0.009), but not weight-for-length (WFL) of infants (p = 0.511), was an independent predictor of internal APD at the compression landmark. Conclusion This study demonstrated correlations between external and internal APDs which were affected by BMI but not WFL (infants). Clinical studies are needed to validate current chest compression guidelines especially for infants and overweight/obese adolescents. (250 words)

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Predictive Value of Estimated Lean Body Mass for Neurological Outcomes after Out-of-Hospital Cardiac Arrest

Cited by 2 publications

References 32 publications

Lower limb muscle matters in patients with hypoxic brain injury following out-of-hospital cardiac arrest

Lower limb muscle matters in patients with hypoxic brain injury following out-of-hospital cardiac arrest

Should paediatric chest compression depth targets consider body habitus? – A chest computed tomography imaging study

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