Predictive Value of Intraoperative Thromboelastometry for the Risk of Perioperative Excessive Blood Loss in Infants and Children Undergoing Congenital Cardiac Surgery

Kim, E.; Shim, Haeng Seon; Kim, W. H.; Lee, S. Y.; Park, S. K.; Yang, Jeyul; Jun, Gyuchan Thomas; Kim, C. S.

doi:10.1097/sa.0000000000000286

Cited by 2 publications

(2 citation statements)

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“…For example, one study reported no significant correlations between either TEG functional fibrinogen level (FLEV) or maximal amplitude (MA) and Clauss fibrinogen level at baseline or 10 min postprotamine in cardiac surgery patients [37]. The different correlations were also reported for children at different ages [40, 41].…”

Section: Measurement Of Fibrinogen Levels and Functionsmentioning

confidence: 99%

Thromboelastography and Thromboelastometry in Assessment of Fibrinogen Deficiency and Prediction for Transfusion Requirement: A Descriptive Review

Peng

Nascimento

Beckett

2018

BioMed Research International

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Fibrinogen is crucial for the formation of blood clot and clinical outcomes in major bleeding. Both Thromboelastography (TEG) and Rotational Thromboelastometry (ROTEM) have been increasingly used to diagnose fibrinogen deficiency and guide fibrinogen transfusion in trauma and surgical bleeding patients. We conducted a comprehensive and comparative review on the technologies and clinical applications of two typical functional fibrinogen assays using TEG (FF TEG) and ROTEM (FIBTEM) for assessment of fibrinogen level and deficiency, and prediction of transfusion requirement. Clot strength and firmness of FF TEG and ROTEM FIBTEM were the most used parameters, and their associations with fibrinogen levels as measured by Clauss method ranged from 0 to 0.9 for FF TEG and 0.27 to 0.94 for FIBTEM. A comparison of the interchangeability and clinical performance of the functional fibrinogen assays using the two systems showed that the results were correlated, but are not interchangeable between the two systems. It appears that ROTEM FIBTEM showed better associations with the Clauss method and more clinical use for monitoring fibrinogen deficiency and predicting transfusion requirements including fibrinogen replacement than FF TEG. TEG and ROTEM functional fibrinogen tests play important roles in the diagnosis of fibrinogen-related coagulopathy and guidance of transfusion requirements. Despite the fact that high-quality evidence is still needed, the two systems are likely to remain popular for the hemostatic management of bleeding patients.

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Section: Measurement Of Fibrinogen Levels and Functionsmentioning

confidence: 99%

Thromboelastography and Thromboelastometry in Assessment of Fibrinogen Deficiency and Prediction for Transfusion Requirement: A Descriptive Review

Peng

Nascimento

Beckett

2018

BioMed Research International

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“…Thromboelastography and thromboelastography with platelet mapping are increasingly used to assess bleeding risk and guide transfusion strategy in cardiac surgery (35)(36)(37)(38), trauma (39,40), and liver transplantation (41,42) and to guide anticoagulation management in patients with ventricular assist devices (43). Individual studies have suggested benefits including mortality reduction and alteration in transfusion profiles (44)(45)(46).…”

Section: Section 4: Novel Anticoagulation Monitoringmentioning

confidence: 99%

Bleeding and Thrombosis With Pediatric Extracorporeal Life Support: A Roadmap for Management, Research, and the Future From the Pediatric Cardiac Intensive Care Society: Part 2*

Penk

Reddy

Polito

et al. 2019

Pediatric Critical Care Medicine

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Objectives: To make recommendations on improving understanding of bleeding and thrombosis with pediatric extracorporeal life support including future research directions. Data Sources: Evaluation of literature and consensus conferences of pediatric critical care and extracorporeal life support experts. Study Selection: A team of 10 experts with pediatric cardiac and extracorporeal membrane oxygenation experience and expertise met through the Pediatric Cardiac Intensive Care Society to review current knowledge and make recommendations for future research to establish "best practice" for anticoagulation management related to extracorporeal life support. Data Extraction/Data Synthesis: This white paper focuses on clinical understanding and limitations of current strategies to monitor anticoagulation. For each test of anticoagulation, limitations of current knowledge are addressed and future research directions suggested.

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Predictive Value of Intraoperative Thromboelastometry for the Risk of Perioperative Excessive Blood Loss in Infants and Children Undergoing Congenital Cardiac Surgery

Cited by 2 publications

References 0 publications

Thromboelastography and Thromboelastometry in Assessment of Fibrinogen Deficiency and Prediction for Transfusion Requirement: A Descriptive Review

Thromboelastography and Thromboelastometry in Assessment of Fibrinogen Deficiency and Prediction for Transfusion Requirement: A Descriptive Review

Bleeding and Thrombosis With Pediatric Extracorporeal Life Support: A Roadmap for Management, Research, and the Future From the Pediatric Cardiac Intensive Care Society: Part 2*

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