Predictive value of mid luteal progesterone concentration before luteal support in controlled ovarian hyperstimulation with intrauterine insemination

Abstract

Increased mid luteal serum P4 levels are not associated with a higher CPR in women undergoing COH with IUI. However, a low mid luteal P4 level < or =25 nmol/L may help predict treatment failure.

The effect of luteal phase support protocol on cycle outcome and luteal phase hormone profile in long agonist protocol intracytoplasmic sperm injection cycles: a randomized clinical trial

“…With regard to the significance of midluteal level of P 4 , it was reported that luteal P 4 level in stimulated cycles does not predict cycle outcome (27) and that even too much P 4 may be somewhat detrimental (28). In concordance with this finding our data regarding serum P 4 agrees with this conclusion where study group III (P 4 plus hCG) had the highest serum P 4 level followed by group I and then group II, which had the lowest serum P 4 .…”

GnRH agonist administration at the time of implantation does not improve pregnancy outcome in intrauterine insemination cycles: a randomized controlled trial

“…In IUI, a low midluteal P level has been described as a predictor of treatment failure (33). It is assumed that the luteal-phase deficiency and the luteolytic effect of the GnRH agonist (2,11,34,35) are overcome by P administration in the luteal phase of ART cycles (30).…”

Does Progesterone Suppository to Luteal Phase Support Have Any Effect on Pregnancy Rates in the Intrauterine Insemination Cycles?

“…As well as, Ebrahimi and colleagues in a clinical trial concluded that the progesterone suppositories does not effect on improving IUI treatment [12]. In a retrospective study by Costello in 2004, they published no positive significant relation between the luteal phase support by progesterone in IUI cycles and increasing pregnancy rate [13]. Enumeration data presented as N (%) with P-value obtained from chi-square or fisher exact tests.…”