Predictive value of N-terminal-Pro brain natriuretic peptide in the detection of coronary artery disease in patients with positive myocardial perfusion imaging

Rahmani, Reza; Shafiee, Akbar; Parazaran, Kambiz; Reshadati, Najmeh

doi:10.47176/mjiri.33.14

Cited by 3 publications

(3 citation statements)

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“…Today, MPI has become a very promising method for brain imaging [335][336][337][338][339][340]. Within a preclinical setting, MPI has proven to be high spatial (more than 46 volumes per second) [323] and temporal resolution (below 1 mm) [327,341] with high sensitivity (with a detection limit of 5 ng of iron) [342,343].…”

Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Magnetic nanoparticles in nanomedicine: a review of recent advances

et al. 2019

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Nanomaterials, in addition to their small size, possess unique physicochemical properties that differ from bulk materials, making them ideal for a host of novel applications. Magnetic nanoparticles (MNPs) are one important class of nanomaterials that have been widely studied for their potential applications in nanomedicine. Due to the fact that MNPs can be detected and manipulated by remote magnetic fields, it opens a wide opportunity for them to be used in vivo. Nowadays, MNPs have been used for diverse applications including magnetic biosensing (diagnostics), magnetic imaging, magnetic separation, drug and gene delivery, and hyperthermia therapy, etc. Specifically, we reviewed some emerging techniques in magnetic diagnostics such as magnetoresistive (MR) and micro-Hall (μHall) biosensors, as well as the magnetic particle spectroscopy, magnetic relaxation switching and surface enhanced Raman spectroscopy (SERS)-based bioassays. Recent advances in applying MNPs as contrast agents in magnetic resonance imaging and as tracer materials in magnetic particle imaging are reviewed. In addition, the development of high magnetic moment MNPs with proper surface functionalization has progressed exponentially over the past decade. To this end, different MNP synthesis approaches and surface coating strategies are reviewed and the biocompatibility and toxicity of surface functionalized MNP nanocomposites are also discussed. Herein, we are aiming to provide a comprehensive assessment of the state-of-the-art biological and biomedical applications of MNPs. This review is not only to provide in-depth insights into the different synthesis, biofunctionalization, biosensing, imaging, and therapy methods but also to give an overview of limitations and possibilities of each technology.

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Section: Magnetic Resonance Imaging (Mri)mentioning

confidence: 99%

Magnetic nanoparticles in nanomedicine: a review of recent advances

et al. 2019

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“…This indicate different stimulus for synthesis in this two localizations (1). Similarly, other studies showed higher values of this marker in patients with higher oxidative stress: patients with multiple CV risk factors (7) and percutaneous coronary interventions (PCI) in spite of stable intraventricular pressure (8).NT-proBNP can serve as a sensitive marker for diagnosis NSTE-ACS patients (9).It is associated with all AMI, but is a more powerful risk factor for microsize than typical MI (10).NT-proBNP level in patients with AMI is independently associated with extent, severity, and complexity of coronary artery disease assessed by SYNTAX score (12).…”

Section: Discussionmentioning

confidence: 65%

Nt-Probnp in Patients with Acute Myocardial Infarction Without Heart Failure

Vlajovic,

Andrejic,

Sreckovic

et al. 2023

Experimental and Applied Biomedical Research (EABR)

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NT-proBNP is marker of acute heart failure. Recent investigation implicate its role in different cardiac and non-cardiac diseases and different mechanism of release in patients with STEMI and NSTEMI. Our study included 66 patients with diagnosis of acute myocardial infarction, hospitalized in Clinical Centre Kragujevac. We evaluated standard biochemical analysis including NTproBNP, electrocardiography, transthoracic echocardiography and coronary angiography. The most common cardiovascular risk factors were emotional stress (93,94%), and physical inactivity( 81,82%). NT-proBNP values were higher in patients with AMI vs health volunteers (943 vs. 162,5 pg/ml, p = 0,0001), NSTEMI vs STEMI patients (1427 pg/ml vs. 592 pg/m, p = 0,005), patients with culprit lesion on left vs right coronary artery (1421 vs. 548, p =0.02), and anterior vs inferior location AMI (1714vs. 625, p =0.022). We found positive correlation NT-proBNP values with CRP, urea, creatinine, and negative correlation with triglicerides, hemoglobin, left ventricular ejection fraction. Higher values of NT-proBNP values are recorded in patients with AMI, NSTEMI, anterior location AMI and with culprit lesion on left coronary artery.

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“… 26 the level of NT-proBNP in plasma is significantly positively correlated with the degree of coronary artery stenosis, and it is basically the same as the evaluation of Gensini coefficient, which reflects the condition of coronary artery disease. 27 Moreover, with the increase of the number of diseased coronary arteries, the content of NT-probNP also increased. 28 It was confirmed in the study by D’Amato et al 29 that the serum level of NT-proBNP in the CHD group was significantly higher than that in the non-CHD group.…”

Section: Discussionmentioning

confidence: 98%

Clinical significance of N-terminal natriuretic peptide combined with inflammatory factors, oxidative stress factors and blood lipid detection in elderly patients with Type-2 diabetes complicated with coronary heart disease

Meng¹,

Kang

Li³

et al. 2022

Pak J Med Sci

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Objectives: To observe the clinical significance of N-terminal natriuretic peptide combined with inflammatory factors, oxidative stress factors and blood lipid detection in elderly patients with Type-2 diabetes complicated with CHD (CHD), and provide a theoretical basis for the diagnosis and treatment of elderly patients with Type-2 diabetes complicated with CHD. Methods: A total of 40 patients with Type-2 diabetes complicated with CHD admitted to Affiliated Hospital of Hebei University from July 2019 and July 2020 were selected as the experimental group, and 40 patients with CHD who were hospitalized in our hospital during the same period without diabetes were selected as the control group. Venous blood was taken from all patients on morning and fasting basis, and their serum inflammatory factors as well as antioxidant molecules were examined respectively. Serum inflammatory factors include serum tumor necrosis factor α (TNF-A), interleukin-6 (IL-6), and C-reactive protein. Antioxidant molecules include antioxidant molecules superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), total antioxidant capacity (TAC), catalase (CAT), glutathione reductase (GR), N-terminal natriuretic peptide (NT‑proBNP), white blood cells (WBC), hemoglobin (HBG), albumin (ALB) and blood lipid levels. The differences of the above indexes between experimental group and control group were compared and analyzed. Results: The serum levels of TNF-a, CRP, and IL-6 in the experimental group were apparently higher than those in the control group, with a statistically significant difference (P=0.00); The levels of SOD, TAC and CAT in the experimental group were significantly lower than those in the control group, with a statistically significant difference (P=0.00); The level of NT-proBNP and WBC count in the experimental group were significantly higher than those in the control group, with a statistically significant difference (NT-proBNP, P=0.01; WBC, P=0.00). However, no statistically significant difference was observed in the levels of HBG and ALB between the two groups (P>0.05). The experimental group had significantly higher TC and TG levels than the control group, with statistically significant differences (TC, P=0.01; TG, P=0.02), but had a significantly lower HDL level than the control group, with a statistically significant difference (P=0.00). Conclusion: Elderly patients with Type-2 diabetes complicated with CHD showed systemic microinflammation, decreased antioxidant molecule content, as well as myocardial damage and abnormal lipid metabolism compared with patients with CHD alone. For this reason, attention should be paid to the above risk factors in clinical practice, and proactive prevention and treatment should be taken to reduce the probability of related complications. doi: https://doi.org/10.12669/pjms.38.5.5513 How to cite this:Meng X, Kang S, Li J, Zhang H, Li M. Clinical significance of N-terminal natriuretic peptide combined with inflammatory factors, oxidative stress factors and blood lipid detection in elderly patients with Type-2 diabetes complicated with coronary heart disease. Pak J Med Sci. 2022;38(5):---------. doi: https://doi.org/10.12669/pjms.38.5.5513 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Predictive value of N-terminal-Pro brain natriuretic peptide in the detection of coronary artery disease in patients with positive myocardial perfusion imaging

Abstract: Background the diagnosis o in the selection between the lev Methods: In Imam Khomei patients on the Results: We stenotic vessel. independently accuracy of 61 and NT-Pro BN Conclusion: CAD and there

Cited by 3 publications

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Magnetic nanoparticles in nanomedicine: a review of recent advances

Magnetic nanoparticles in nanomedicine: a review of recent advances

Nt-Probnp in Patients with Acute Myocardial Infarction Without Heart Failure

Clinical significance of N-terminal natriuretic peptide combined with inflammatory factors, oxidative stress factors and blood lipid detection in elderly patients with Type-2 diabetes complicated with coronary heart disease

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