Predictive value of non-invasive parameters in patients with left ventricular hypertrophy during a five-year follow-up period

Djordjević, Dragan; Tasić, I.; Stamenković, Bojana

doi:10.2298/sarh1210571d

Cited by 4 publications

(28 citation statements)

References 27 publications

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“…Eliakim-Raz et al [27] reported an association between IVS thickening and future development of hypertension in a young healthy cohort of 500 Israeli Air Force aviators and argued that IVS thickening may not merely be a result of long-term BP elevation, but may predict the development of systolic hypertension. In a study of hypertensive patients receiving regular treatment, multivariate adjusted analysis showed that greater IVST at baseline was associated with worse cardiovascular outcomes during 5 years of follow-up [28]. Huang et al [29] concluded that thickened IVS can be served as a reliable marker for predicting all-cause death in Chinese patients with coronary artery disease, even in those with normal LVM.…”

Section: Discussionmentioning

confidence: 99%

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Zhang

Guo

et al. 2019

Kidney Blood Press Res

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Background: Cardiovascular disease is the leading cause of morbidity and mortality in maintenance hemodialysis (MHD) patients. Uremic cardiomyopathy, characterized by myocardial hypertrophy and fibrosis, has a significant contribution to these adverse cardiac outcomes. The protective effect of soluble Klotho (s-Klotho) on myocardial damage was demonstrated in in vitro and animal experiments. However, data from MHD patients is limited. The present study was designed to identify potential correlations between echocardiographic parameters and serum s-Klotho levels in MHD patients. Methods: This is a cross-sectional study involving 105 MHD patients from the Dialysis Center of Capital Medical University affiliated Beijing Friendship Hospital between March and October 2014. The general information for each patient was recorded. Fasting blood samples were collected prior to hemodialysis during the mid-week session in all patients. The echocardiogram and left lateral lumbar spine radiograph were performed after the same mid-week session. The dialysis records for each session within 3 months before the blood tests were documented. According to the quartiles of s-Klotho levels, patients were divided into four groups (Group 1–4). The demographic and clinical characteristics, echocardiographic parameters, and abdominal aortic calcification scores among the groups were compared. Results: The enrolled 105 patients were predominantly male (54.3%) with an average age of 59.9 ± 11.2 years. Previous hemodialysis durations were 76 (42–133) months. Sixteen (15.2%) patients had diabetes mellitus. Mean serum s-Klotho level was 411.83 ± 152.95 pg/mL, and the 25th percentile, 50th percentile, and 75th percentile values of serum s-Klotho levels were 298.9, 412, and 498.2 pg/mL, respectively. Individuals in the bottom quartile of s-Klotho levels (Group 1) had significantly increased interventricular septal thickness (IVST) compared to those in the other three quartiles of s-Klotho levels (Group 1: 1.12 ± 0.16 cm; vs. Group 2: 1.12 ± 0.16 cm, p = 0.008; vs. Group 3: 0.94 ± 0.13 cm, p < 0.001; vs. Group 4: 1.03 ± 0.1 5 cm, p = 0.022). There were significant differences in the ratios of IVST and posterior wall thickness (PWT) between patients of Group 1 and Group 3 (1.12 ± 0.1 2 vs. 1.00 ± 0.1 4, p = 0.004). No significant differences were found for other parameters among the groups. The univariate correlation analyses showed that gender (r = –0.211, p = 0.030), Kt/V urea (r = –0.240, p = 0.014), hypersensitive C reactive protein (hs-CRP) (r = 0.196, p = 0.045), and serum s-Klotho levels (r = –0.260, p = 0.007) significantly correlated with IVST. Ultimately, only hs-CRP and serum s-Klotho levels were entered into a multiple regression model. Conclusions: The present study showed that patients with lower circulating s-Klotho levels were more often associated with larger IVST and greater ratios of IVST and PWT. There was an independent association between s-Klotho and IVST, and lower s-Klotho levels seem to be a potential risk factor of uremic...

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Section: Discussionmentioning

confidence: 99%

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Zhang

Guo

et al. 2019

Kidney Blood Press Res

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“…Some studies focusing on patients with particular disease suggested that increased IVS thickness was associated with increased risk of adverse events. For example, in a study of hypertensive patients receiving regular treatment, multivariate adjusted analysis showed that greater IVS thickness at baseline was associated with worse cardiovascular outcomes during 5 years follow up . In a study of patients undergoing isolated aortic valve replacement, van Straten et al .…”

Section: Discussionmentioning

confidence: 99%

Increased interventricular septum wall thickness predicts all‐cause death in patients with coronary artery disease

Huang

Peng

Liu

et al. 2015

Internal Medicine Journal

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“…One hundred twenty‐four patients (average age, 57.0 ± 8.0 years; 84 males and 40 females) were either under 10‐year treatment and monitoring or passed away due to CV events during the monitoring period. A detailed description of the criteria for examination and inclusion of the patients in the study was provided in previously published study, which implied a 5‐year follow‐up of 90 patients . During the period of follow‐up, the basic therapy was changed according to currently valid guidelines for treatment of patients with AH.…”

Section: Methodsmentioning

confidence: 99%

“…An electrocardiogram (ECG) was recorded using EKG‐300 (Electronic Industry Niš, Niš, Serbia) with standard calibration and speed of 50 m/s for calculation of corrected QT interval (QTc) dispersion . The criteria for LVH were applied according to published guidelines (Lyon‐Sokolow score > 38 mm; Cornell product ≥2.440 mm × msec) .…”

Section: Methodsmentioning

confidence: 99%

“…Considering that the LVH is a product of many known and unknown factors in AH, it is important to know if there are any other noninvasive parameters (except for LVH) that can predict adverse CV events and mortality. This 10‐year follow‐up study is an extension of a previously published study that has offered a 5‐year follow‐up cross‐section of a smaller number of patients …”

Section: Introductionmentioning

confidence: 99%

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QTc dispersion and Cornell duration product can predict 10‐year outcomes in hypertensive patients with left ventricular hypertrophy

Djordjević

Tasić

Kostić³

et al. 2017

Clinical Cardiology

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Background Persistent and adequate treatment of patients with arterial hypertension leads to more favorable disease outcome. Hypothesis Aside for the present left ventricular hypertrophy (LVH), there are other non‐invasive parameters which can represent additional predictors of unfavorable prognosis in patients with essential arterial hypertension during the 10‐year follow‐up. Methods A hypertensive group with LVH (124 patients; age 57.0 ± 8.0; 84 males and 40 females) was included in the study and examined noninvasively. Patients used regular medication therapy during the follow‐up period. Results During the 10‐year follow‐up period, unfavorable outcome was recorded for 40 (32.3%) patients. Patients with unfavorable outcome had higher baseline values of left ventricular mass index (178.9 ± 29.5 g/m2 vs 165.5 ± 29.5 g/m2; P < 0.05) and QTc dispersion (64.1 ± 24.7 ms vs 54.8 ± 19.4 ms; P < 0.05). Frequency of positive Cornell product was higher in the group of patients with unfavorable outcome (35% vs 22.2%; P < 0.01). Positive Lyon‐Sokolow score did not show statistical significance (25% vs 11.9%; P = 0.06). Cornell product (β = 0.234; P < 0.01) and QTc dispersion >65 ms (β = 0.184; P < 0.05) had prognostic significance in LVH (multiple regression analysis: R = 0.314, R = 0.099, adjusted R = 0.084, standard error of the estimate = 0.449, P < 0.05). Conclusions Patients with a positive Cornell product and larger QTc dispersion had more unfavorable 10‐year outcomes compared with other patients with LVH.

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Predictive value of non-invasive parameters in patients with left ventricular hypertrophy during a five-year follow-up period

Cited by 4 publications

References 27 publications

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Relationship of Serum Soluble Klotho Levels and Echocardiographic Parameters in Patients on Maintenance Hemodialysis

Increased interventricular septum wall thickness predicts all‐cause death in patients with coronary artery disease

QTc dispersion and Cornell duration product can predict 10‐year outcomes in hypertensive patients with left ventricular hypertrophy

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