Predictive Value of Serum Ferritin in Combination with Alanine Aminotransferase and Glucose Levels for Noninvasive Assessment of NAFLD: Fatty Liver in Obesity (FLiO) Study

Galarregui, Cristina; Marín-Alejandre, Bertha Araceli; Pérez-Díaz-del-Campo, Nuria; Cantero, Irene; Monreal, J Ignacio; Elorz, Mariana; Benito-Boillos, Alberto; Herrero, J.I.; Tur, Josep A.; Martínéz, J. Alfredo; Zulet, M. Ángeles; Abete, Itziar

doi:10.3390/diagnostics10110917

Cited by 11 publications

(12 citation statements)

References 52 publications

(75 reference statements)

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“…TG and HDL have been proved to be closely related to fatty liver (49), and the result of multivariate analysis also re ected the signi cant in uence of TG and HDL in the identi cation of patients with MAFLD. Consistent with our study, existed evidences showed that elevated ALT played an important role in the occurrence and progression of FLD (50,51). Our nding also suggested that ALT abnormalities should be considered as an important factor in the classi cation of high-risk individuals for MAFLD.…”

Section: Discussionsupporting

confidence: 91%

Is Helicobacter pylori infection the risk factor of metabolic associated fatty liver disease：A cross-sectional study

Zeng

Jing

et al. 2022

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Background: Recently, with new diagnosis criteria, metabolic associated fatty liver disease (MAFLD) was introduced to replace the diagnosis of nonalcoholic fatty liver disease (NAFLD). Considering that there weren’t sufficient studies on MAFLD in China, we aimed to explore the relationship between MAFLD and H. pylori infection, as well as the potential risk factors of MAFLD.Methods: In this cross-sectional study, 3449 subjects were enrolled from a Hospital Health Management Center of Shantou in China between July 2020 and October 2021. All participants included had underwent blood test, 13C urea breath test (13C-UBT) and abdominal ultrasound examination. The association between H. pylori infection and MAFLD were analyzed using logistic regression. Machine learning approach were applied to explore independent risk factors of MAFLD.Results: The overall prevalence of MAFLD was 39.4% in our study population. Of a total of 3449 participants, MAFLD was diagnosed in 1043 of 2254 males (46.3%) and 315 of 1195 females (26.4%). The prevalence of MAFLD increased with age and peaked at the 60-69-year age group (overall participants: 58.8%; male: 56.2%; female: 64.0%), and then declined slightly in the 70-above-year age group. The result of multivariable logistic regression revealed that H. pylori infection was not significantly correlated with MAFLD. Using logistic regression and LASSO regression, we identified age, overweight/obesity, T2DM, hypertension, UA, TG, HDL and ALT as independent risk factors of MAFLD.Conclusions: The prevalence of MAFLD in Shantou of south China was relatively high, and the prevalence was higher in males than in females. Our results showed that H. pylori infection wasn’t associated with the risk of MAFLD, when age, overweight/obesity, T2DM, hypertension, UA, TG, HDL and ALT were independent risk factors of MAFLD.

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Section: Discussionsupporting

confidence: 91%

Is Helicobacter pylori infection the risk factor of metabolic associated fatty liver disease：A cross-sectional study

Zeng

Jing

et al. 2022

Preprint

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Section: Discussionmentioning

confidence: 99%

“…Several cross-sectional and case-control studies have assessed the association between serum ferritin levels and the risk of NAFLD [24][25][26][27]. Recent a cross-sectional study found that serum ferritin positively associated with alanine aminotransferase (ALT) among subjects with overweight/obesity and ultrasound-con rmed liver steatosis [24]. Two cross-sectional studies also showed that higher serum ferritin was associated with a higher risk of NAFLD and elevated ALT among Chinese adults with normal weight [25,26].…”

Section: Discussionmentioning

confidence: 99%

Serum ferritin as an independent predictor of non-alcohol fatty liver disease in general adults: the TCLSIH cohort study

Meng

Chen

et al. 2022

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Background Serum ferritin is an important iron storage protein in the human body, which indicates iron storage and the body’s nutritional status, and is associated with a variety of chronic diseases. Few prospective studies have assessed the association between serum ferritin levels and non-alcoholic fatty liver disease (NAFLD). This prospective cohort study aimed to explore whether serum ferritin levels were associated with the incidence of NAFLD in a large-scale adult population. Methods A total of 15,748 participants without baseline NAFLD were enrolled in the cohort study (1-9 years follow-up periods, median: 4.5 years). Serum ferritin levels were determined by protein chip-chemiluminescence method, and NAFLD was diagnosed by abdominal ultrasonography. Multivariable Cox proportional hazards regression models were used to assess the association between baseline serum ferritin levels and the risk of NAFLD. Results During the follow-up period, 3,374 new NAFLD cases were observed, and the incidence rate of NAFLD was 83.4 per 1000 person-years. In the fully adjusted model, the hazards ratios (95% confidence interval) for incident NAFLD across serum ferritin levels quartiles were 1.06 (0.94-1.19), 1.25 (1.11-1.41), and 1.52 (1.28-1.79) (P for trend <0.0001). Receiver operating characteristic (ROC) analysis showed that the optimal cut-off values were 55.9 mg/dl for serum ferritin levels (Area under the ROC curve (AUC)=0.61) Conclusion Increased serum ferritin level was independently associated with a higher risk of incident NAFLD in a large-scale general population. It is suggested that serum ferritin levels can be useful for the early detection of subjects at high risk of developing NAFLD.

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“…Therefore, participants were merged and compared together. The habitual dietary intake was registered with a validated semi-quantitative food frequency questionnaire (FFQ) of 137 items, both at baseline and after the 6-month intervention [38,39]. The composition of the food items was derived from accepted Spanish food composition tables as previously described [4,40].…”

Section: Dietary and Lifestyle Interventionmentioning

confidence: 99%

Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study

et al. 2021

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Non-alcoholic fatty liver disease (NAFLD) affects 25% of the global population. The pathogenesis of NAFLD is complex; available data reveal that genetics and ascribed interactions with environmental factors may play an important role in the development of this morbid condition. The purpose of this investigation was to assess genetic and non-genetic determinants putatively involved in the onset and progression of NAFLD after a 6-month weight loss nutritional treatment. A group of 86 overweight/obese subjects with NAFLD from the Fatty Liver in Obesity (FLiO) study were enrolled and metabolically evaluated at baseline and after 6 months. A pre-designed panel of 95 genetic variants related to obesity and weight loss was applied and analyzed. Three genetic risk scores (GRS) concerning the improvement on hepatic health evaluated by minimally invasive methods such as the fatty liver index (FLI) (GRSFLI), lipidomic-OWLiver®-test (GRSOWL) and magnetic resonance imaging (MRI) (GRSMRI), were derived by adding the risk alleles genotypes. Body composition, liver injury-related markers and dietary intake were also monitored. Overall, 23 SNPs were independently associated with the change in FLI, 16 SNPs with OWLiver®-test and 8 SNPs with MRI, which were specific for every diagnosis tool. After adjusting for gender, age and other related predictors (insulin resistance, inflammatory biomarkers and dietary intake at baseline) the calculated GRSFLI, GRSOWL and GRSMRI were major contributors of the improvement in hepatic status. Thus, fitted linear regression models showed a variance of 53% (adj. R2 = 0.53) in hepatic functionality (FLI), 16% (adj. R2 = 0.16) in lipidomic metabolism (OWLiver®-test) and 34% (adj. R2 = 0.34) in liver fat content (MRI). These results demonstrate that three different genetic scores can be useful for the personalized management of NAFLD, whose treatment must rely on specific dietary recommendations guided by the measurement of specific genetic biomarkers.

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Predictive Value of Serum Ferritin in Combination with Alanine Aminotransferase and Glucose Levels for Noninvasive Assessment of NAFLD: Fatty Liver in Obesity (FLiO) Study

Cited by 11 publications

References 52 publications

Is Helicobacter pylori infection the risk factor of metabolic associated fatty liver disease：A cross-sectional study

Is Helicobacter pylori infection the risk factor of metabolic associated fatty liver disease：A cross-sectional study

Serum ferritin as an independent predictor of non-alcohol fatty liver disease in general adults: the TCLSIH cohort study

Three Different Genetic Risk Scores Based on Fatty Liver Index, Magnetic Resonance Imaging and Lipidomic for a Nutrigenetic Personalized Management of NAFLD: The Fatty Liver in Obesity Study

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