Predictive value of serum markers for postacne scarring

El-Taweel, A.I.; Salem, Rehab Mohammed; El-Shimi, O.S.

doi:10.1111/jocd.12402

Cited by 5 publications

(7 citation statements)

References 21 publications

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“…There were no statistically significant differences between the patient groups and control healthy group regarding gender and age and marital status between the studied groups (matched groups). This came in agreement with El-Taweel et al [22] who found that There were 44 (73.3%) female and 16 male (26.7%) patients. Female predominance may be due to hormonal changes during menstruation or higher level of stress among females [18] .…”

Section: Discussionsupporting

confidence: 92%

“…Our results demonstrated that the range of patients age with acne lesions was 14.0 to 33.0 years with a mean of (23.5±5.77), in patients with post acne scars was15.0 to 35.0 years with a mean of (24.63±5.05) and in control group was 15.0 to 35.0 years with a mean of (25.80±5.81).The mean age in our study was in agreement with El-Taweel et al [22] who found that the mean age of the acne patients was( 19.57 ± 2.81 years).…”

Section: Discussionsupporting

confidence: 91%

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Hepcidin Polymorphism in Association with Plasma Hepcidin Level as Potential Risk Factors for Acne Severity and Post Acne Scarring

Sultan¹,

Elsohafy²,

Abdelsalam³

et al. 2023

The Egyptian Journal of Hospital Medicine

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Background: Acne vulgaris (AV) is an inflammatory disease of pilosebaceous follicles. It has multifactorial causes and is manifested as blackheads, papules, pustules, nodules, as well as cysts. The significantly greater serum hepcidin values among acne cases that do not develop post-acne scarring support its antifibrotic activities that were clarified by its capability of impeding transforming growth factor β1(TGF β1) induced Smad3 phosphorylation. Objective: The aim of the current work was to assess hepcidin gene polymorphism and plasma hepcidin level in acne vulgaris cases of varying severity with and without post-acne scaring. Patients and Methods: This case-control study included a total of 30 cases with AV with no post-acne scars, 30 cases with AV and post acne scar and 30 subjects of age and gender matched healthy controls, attending at

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Section: Discussionsupporting

confidence: 92%

Section: Discussionsupporting

confidence: 91%

Hepcidin Polymorphism in Association with Plasma Hepcidin Level as Potential Risk Factors for Acne Severity and Post Acne Scarring

Sultan¹,

Elsohafy²,

Abdelsalam³

et al. 2023

The Egyptian Journal of Hospital Medicine

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“…It was thought that scars mainly follow nodulocystic acne lesions, but it has been shown that even noninflammatory acne lesions and mild degrees of acne can cause disfiguring postacne scarring 33 . That's why it would be of great benefit to find out more reliable laboratory markers 34 or genetic factors which would help in expecting patients susceptible to postacne scarring formation more accurately. The small sample size and not correlating different genotypes with the tissue expression of MMP‐1 and TIMP‐1 are the main study limitations.…”

Section: Discussionmentioning

confidence: 99%

Section: F I G U R E 3 Timp-1 (372 C/t) Alleles and Genotypes In Male...mentioning

confidence: 99%

MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) genes polymorphism in an Egyptian sample of Acne vulgaris patients

Mohammed¹,

Sabry

Ameen

et al. 2021

J of Cosmetic Dermatology

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Background Different Matrix metalloproteinases (MMPs) family members may be implicated in acne vulgaris development. However, there are no published data about the role of MMP‐1 and TIMP‐1 gene polymorphisms in acne vulgaris development. Aims To evaluate the association between MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) gene polymorphisms and the risk of developing acne vulgaris among a sample of Egyptian acne patients. Patients/Methods This case‐control study included 100 acne vulgaris patients and 120 apparently healthy control subjects. Acne severity was assessed according to Global Acne Grading System (GAGS). MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) gene polymorphisms were investigated using RFLP‐PCR technique. Results The MMP‐1 (519 A/G) AG and GG genotypes and G allele increase the risk of acne vulgaris~2–3 folds. In female patients, TIMP‐1 (372 C/T) TT genotype and T allele showed significantly higher frequency in cases compared with the control group (p = 0.004, 0.001 respectively) with a higher risk to develop acne. On the other hand, in male patients, there was insignificant difference between the frequency of alleles in patients and control subjects. TIMP‐1 (372C/T) TT genotype has been shown to be significantly detected in the studied female patients associated with the positive family history of the disease, and it increases the risk of back affection, severe acne grade development, and the liability to postacne scar formation. Conclusion MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) gene polymorphisms may be related to acne vulgaris development.

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“…C sensitive protein (CRP) may be proportionally correlates of the seriousness for incendiary skin inflammation vulgaris. Its vicinity over av might help those group defenses against p. Acnes and also to tissue harm through its Different movements of the included resistant phones and incendiary mediators [18]. Serum follistatin focuses in people gives the idea should parallel serum ctouchy protein levels [19].…”

Section: Discussionmentioning

confidence: 99%

Serum Level of Follistatin in Patients with Scarring and non Scarring Acne Vulgaris

El-Taweel

Mustafa

Haleem

et al. 2020

Benha Journal of Applied Sciences

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Acne vulgaris is a chronic cutaneous inflammatory disorder. Four factors play vital roles in acne pathophysiology: hyperseborrhea , altered keratinization of the pilosebaceous duct, propionobacterium acnes (p. acnes) and inflammation. to assess serum level of follistatin in patients with scarring and non scarring AV aiming at understanding the pathogenesis of post acne scars. serum FST level was assessed in 60 acne patients (30 non scarring patients -30 scarring patients) and 20 apparently healthy subjects as control with matched age and sex. Every patient included in the study was subjected to detailed history taking, complete general and dermatological examination and assessment of serum level of FST by using commercial ELISA kits.AV, non scarring and scarring patients had significantly higher frequency with positive family history, sun exposure and excess stress when compared to control group (p value 0.010, 0.005 and <0.001 respectively. However , No significant differences were found in risk factors between acne groups. serum FST level was significantly lower in patients with acne than control group although its level was significantly lower in scarring acne patients than non scarring patients.

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Predictive value of serum markers for postacne scarring

Abstract: Serum levels of hepcidin and CRP are promising markers, which may be considered as objective tools to predict the possibility of postacne scarring.

Cited by 5 publications

References 21 publications

Hepcidin Polymorphism in Association with Plasma Hepcidin Level as Potential Risk Factors for Acne Severity and Post Acne Scarring

Hepcidin Polymorphism in Association with Plasma Hepcidin Level as Potential Risk Factors for Acne Severity and Post Acne Scarring

MMP‐1 (519 A/G) and TIMP‐1 (372 T/C) genes polymorphism in an Egyptian sample of Acne vulgaris patients

Serum Level of Follistatin in Patients with Scarring and non Scarring Acne Vulgaris

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