2022
DOI: 10.1016/s0090-8258(22)01299-9
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Predictive value of the Leuven HRD test compared with Myriad myChoice PLUS on 468 ovarian cancer samples from the PAOLA-1/ENGOT-ov25 trial (LBA 6)

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Cited by 21 publications
(21 citation statements)
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“…In addition, another academic network developed the “Leuven” HRD test as a part of the ENGOT European HRD initiative [ 73 ]. On a total of 468 ovarian cancer samples taken from the PAOLA-1/ENGOT-ov25 trial, researchers found a significant correlation between the results of the Leuven HRD and the Myriad myChoice PLUS test.…”
Section: Hrd In a Laboratory Routinementioning
confidence: 99%
“…In addition, another academic network developed the “Leuven” HRD test as a part of the ENGOT European HRD initiative [ 73 ]. On a total of 468 ovarian cancer samples taken from the PAOLA-1/ENGOT-ov25 trial, researchers found a significant correlation between the results of the Leuven HRD and the Myriad myChoice PLUS test.…”
Section: Hrd In a Laboratory Routinementioning
confidence: 99%
“…Finally, these assays are expensive and require central analysis, two factors which are driving the development of academic assays such as AmoyDx HRD Focus Panel 32 and Leuven HRD test. 33 Alongside these institutional efforts, there is an international academic effort underway to identify more reliable, cost-effective HRD assays using samples from the PAOLA-1 trial.…”
Section: Reviewmentioning
confidence: 99%
“…The Leuven HRD test showed a similar impact of olaparib on median PFS as Myriad myChoice test. 136 Other integrative models based on mutational signatures have been developed. HRDetect 137 and Classifier of Homologous Recombination Deficiency (CHORD) 138 are HRD tests based on whole-genome sequencing (WGS) analysis.…”
Section: Biomarkers Of Resistance To Parpimentioning
confidence: 99%