Predictive value of urinary (NAG), alanme-aminopeptidase(AAP) and beta-2-microglobulin (β2M) in evaluating nephrotoxicity of gentamicin

Gibey, R; Dupond, J.L.; Alber, D.; Floris, R; Henry, J. C.

doi:10.1016/0009-8981(81)90165-0

Cited by 111 publications

(58 citation statements)

References 16 publications

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“…The more selective location of NAG in the proximal tubule compared with GGT and LD may be the cause for its higher accuracy (46 ). Other investigators have proposed enzymuria as a marker of ATN severity (26,27,47 ). Their data implied lower sensitivity and higher specificity of enzymuria compared with our data differentiating be- tween ATN with severe or good prognosis.…”

Section: Is Associated With Dramatically Increased Mortality (5 7 )contrasting

confidence: 49%

“…Possibly, early peak urinary excretion of enzymes was missed because ATN patients were not included in the study at the time of the insult that caused the proximal tubular injury, but with some time delay, as is common in clinical practice. This could be important because enzymuria was demonstrated to occur more rapidly after renal injury than tubular proteinuria (21,23,25,27 ). Additionally, urinary excretion of enzymes is markedly diuresis dependent (45 ).…”

Section: Is Associated With Dramatically Increased Mortality (5 7 )mentioning

confidence: 99%

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Prognostic Value of Tubular Proteinuria and Enzymuria in Nonoliguric Acute Tubular Necrosis

Poppen²,

et al. 2004

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Section: Is Associated With Dramatically Increased Mortality (5 7 )contrasting

confidence: 49%

Section: Is Associated With Dramatically Increased Mortality (5 7 )mentioning

confidence: 99%

Prognostic Value of Tubular Proteinuria and Enzymuria in Nonoliguric Acute Tubular Necrosis

Poppen²,

et al. 2004

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“…The mechanisms leading to this event remain unclear, but interactions of the drug with the cell membrane and intracytoplasmic organelles cannot be ruled out (10).…”

Section: Groups (N)mentioning

confidence: 99%

Effect of cyclooxygenase inhibitors on gentamicin-induced nephrotoxicity in rats

Hosaka

Santos

Seguro

et al. 2004

Braz J Med Biol Res

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The frequent use of nonsteroidal anti-inflammatory drugs (NSAID) in combination with gentamicin poses the additional risk of nephrotoxic renal failure. Cyclooxygenase-1 (COX-1) is the main enzyme responsible for the synthesis of renal vasodilator prostaglandins, while COX-2 participates predominantly in the inflammatory process. Both are inhibited by non-selective NSAID such as indomethacin. Selective COX-2 inhibitors such as rofecoxib seem to have fewer renal side effects than non-selective inhibitors. The objective of the present study was to determine whether the combined use of rofecoxib and gentamicin can prevent the increased renal injury caused by gentamicin and indomethacin. Male Wistar rats (250-300 g) were treated with gentamicin (100 mg/kg body weight, ip, N = 7), indomethacin (5 mg/ kg, orally, N = 7), rofecoxib (1.4 mg/kg, orally, N = 7), gentamicin + rofecoxib (100 and 1.4 mg/kg, respectively) or gentamicin + indomethacin (100 and 5 mg/kg, respectively, N = 8) for 5 days. Creatinine clearance and α-glutathione-S-transferase concentrations were used as markers of renal injury. Animals were anesthetized with ether and sacrificed for blood collection. The use of gentamicin plus indomethacin led to worsened renal function (0.199 ± 0.019 ml/min), as opposed to the absence of a nephrotoxic effect of rofecoxib when gentamicin plus rofexicob was used (0.242 ± 0.011 ml/min). These results indicate that COX-2-selective inhibitors can be used as an alternative treatment to conventional NSAID, especially in situations in which risk factors for nephrotoxicity are present.

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“…Measurements of the activities of urinary enzymes were considered as a useful non-invasive test in detecting the deterioration of renal function in the initial stage. The renal enzyme such as Nacetyl-β-D-glusosaminidase (NAG), and the brush border enzyme Gama glutamyl transpeptidase (GGT) have also been used to assess renal toxicity (Periyasamy et al, 2009;Gibey et al, 1981). The damage in the tubules leads to the excretion of NAG and GGT into the lumen of the tubules that were detected in the urine.…”

Section: Introductionmentioning

confidence: 99%

Study of Renal enzymuria and albuminuria activity in the Petals of Pink Nelumbo nucifera Gaertn.

Saraswathi¹,

Shoba²

2015

J App Pharm Sci

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Predictive value of urinary (NAG), alanme-aminopeptidase(AAP) and beta-2-microglobulin (β2M) in evaluating nephrotoxicity of gentamicin

Cited by 111 publications

References 16 publications

Prognostic Value of Tubular Proteinuria and Enzymuria in Nonoliguric Acute Tubular Necrosis

Prognostic Value of Tubular Proteinuria and Enzymuria in Nonoliguric Acute Tubular Necrosis

Effect of cyclooxygenase inhibitors on gentamicin-induced nephrotoxicity in rats

Study of Renal enzymuria and albuminuria activity in the Petals of Pink Nelumbo nucifera Gaertn.

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