2020
DOI: 10.2217/pgs-2020-0044
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Predictive Values of Colon Microbiota in the Treatment Response to Colorectal Cancer

Abstract: The crosstalk between the colon mucosa and the microbiota represents a complex and delicate equilibrium. Gastrointestinal diseases such as inflammatory bowel disease and colorectal cancer (CRC) are associated with a state of altered microbiota composition known as dysbiosis, which seems to play a causative role in some of these illnesses. Recent reports have shown that the colorectal microbiome is responsible for the response and safety to treatments against CRC, especially immunotherapy, hence opening the pos… Show more

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Cited by 6 publications
(2 citation statements)
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“…FMT is the transfer of normal gut microbiota from healthy people to patients, rebuilding the gut microbiota ecosystem (Figure 2B). It has been applied to treat several diseases, including inflammatory bowel disease (IBD), and Clostridioides difficile infection (CDI) (Mohajeri et al, 2018;Galan-Ros et al, 2020;Glassner et al, 2020;Zhang et al, 2020). The survival rate of IBD caused by CDI using the FMT strategy could reach 90% (Basson et al, 2020).…”
Section: Microbiota-targeted Prevention and Treatment Of Cmpamentioning
confidence: 99%
“…FMT is the transfer of normal gut microbiota from healthy people to patients, rebuilding the gut microbiota ecosystem (Figure 2B). It has been applied to treat several diseases, including inflammatory bowel disease (IBD), and Clostridioides difficile infection (CDI) (Mohajeri et al, 2018;Galan-Ros et al, 2020;Glassner et al, 2020;Zhang et al, 2020). The survival rate of IBD caused by CDI using the FMT strategy could reach 90% (Basson et al, 2020).…”
Section: Microbiota-targeted Prevention and Treatment Of Cmpamentioning
confidence: 99%
“…Pesquisa preliminar no MEDLINE, no Cochrane Database of Systematic Reviews e no Joanna Briggs Institute (JBI) Evidence Synthesis, identificou duas revisões acerca da temática, contudo as mesmas diferem do estudo proposto por abordarem também estudos com animais e não tratarem especificamente de quimioterapia endovenosa, não restringindo a metodologia dos estudos elencados, o que justifica a realização deste estudo o qual busca mapear nesta temática estudos com seres humanos (Galan-Ros et al, 2020;Yixia et al, 2021).…”
Section: Introductionunclassified