Predictive Values of the Selected Inflammatory Indexes in Colon Cancer

Abstract

Purpose Ample evidence has revealed that the lymphocyte-to-monocyte ratio (LMR), albumin-to-globulin ratio (AGR), and mean platelet volume (MPV) are cancer-related inflammatory markers. The present study aimed to combine these indicators to better assess the progression of colon cancer. Methods This retrospective study enrolled 251 patients with colon cancer, 171 patients with benign colon diseases, and 187 healthy control subjects. The receiver operating characteristic curve and area under the curve (AUC) were used to determine the diagnostic values of the selected inflammatory index. Results The levels of LMR, AGR, and MPV were decreased in the colon cancer group compared with the healthy control and benign colon disease groups. The LMR, AGR, and MPV were all correlated with tumor size. Moreover, LMR and AGR was associated with lymph node metastasis and clinical stage, AGR was related to distant metastasis. Both the LMR ( P = .030) and AGR ( P = .005) were negatively correlated with the concentration of carcinoembryonic antigen (CEA). The AUC value of MPV combined with CEA had a good diagnostic ability for distinguishing colon cancer cases (AUC = .950) and patients with benign colon diseases (AUC = .886) from controls. Meanwhile, the combination of LMR or AGR with CEA could enhance larger AUC (.746 for LMR + CEA, .737 for AGR + CEA) than CEA, LMR, or AGR alone in detecting colon cancer from benign colon diseases. Conclusions CEA combined with the LMR, AGR, or MPV may be used as better blood-based biomarkers in the progression of colon cancer patients.

Relation of Mean Platelet Volume (MPV) with Cancer: A Systematic Review with a Focus on Disease Outcome on Twelve Types of Cancer

“…Regarding colon cancer, eleven studies were identified [ 13 , 19 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ] including 3463 patients with colon cancer or colorectal cancer ( Table 2 ). Seven studies were conducted in China [ 19 , 38 , 39 , 41 , 43 , 45 , 46 ], two in Turkey [ 40 , 42 ], one in Serbia [ 13 ], and one in Qatar [ 44 ].…”

“…Regarding colon cancer, eleven studies were identified [ 13 , 19 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ] including 3463 patients with colon cancer or colorectal cancer ( Table 2 ). Seven studies were conducted in China [ 19 , 38 , 39 , 41 , 43 , 45 , 46 ], two in Turkey [ 40 , 42 ], one in Serbia [ 13 ], and one in Qatar [ 44 ]. Results were mixed regarding the values of MPV in patients versus controls, with one study showing increased MPV in patients with colon cancer [ 39 ] and one showing decreased MPV levels [ 45 ].…”

“…Seven studies were conducted in China [ 19 , 38 , 39 , 41 , 43 , 45 , 46 ], two in Turkey [ 40 , 42 ], one in Serbia [ 13 ], and one in Qatar [ 44 ]. Results were mixed regarding the values of MPV in patients versus controls, with one study showing increased MPV in patients with colon cancer [ 39 ] and one showing decreased MPV levels [ 45 ]. Patients with metastatic colon cancer also had increased MPV compared to nonmetastatic patients [ 40 ].…”

“…The benefit of chemotherapy was also significantly greater in patients with low MPV compared with patients with high MPV [ 40 ]. Most studies found that reduced MPV is related to increased survival [ 38 , 41 , 42 , 43 ], while two studies had opposite findings [ 19 , 45 ].…”

“…The aim of this systematic review was to investigate the alterations of MPV in various types of cancer in relation to healthy subjects and to assess the relation of MPV to disease outcomes according to data published from 2010 to 2022. In total, 83 studies with 21,034 participants and 12 different types of cancer were included, i.e., gastric cancer [ 15 , 31 , 32 , 33 , 34 , 35 , 36 , 37 ], colon cancer [ 13 , 19 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 ], esophageal squamous cell carcinoma [ 20 , 47 , 48 , 49 , 50 ], renal cancer [ 18 , 51 , 52 ], breast cancer [ 16 , 53 , 54 , 55 , 56 , 57 , 58 , 59 ], ovarian cancer [ 60 , 61 , 62 , 63 , 64 , 65 ], endometrial cancer [ 66 , 67 , 68 , 69 , 70 , 71 , 72 , 73 ], thyroid cancer [ 14 …”