Predictors for Left Ventricular Systolic Dysfunction and its Outcome after Patent Ductus Arteriosus (Pda) Closure by Device

Korejo, Hussain Bux; Shaikh, Attiya; Sohail, Arshad; Chohan, Naresh Kumar; Kumari, Veena; Khan, Muhammad Asif; Patel, Najma

doi:10.4172/2324-8602.1000341

Cited by 2 publications

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“…11 Other studies that assessed systolic function after transcatheter closure had similar results. 12,13 A Yogyakarta study noted a significant increase in body weight after transcatheter PDA closure. But the increased body weight was not associated with sex, birth weight, pulmonary hypertension, heart failure, parental employment, or earnings.…”

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Time period after transcatheter PDA closure with changes in left ventricular function and nutritional status

Irfan¹,

Ali²,

Tobing³

et al. 2021

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Background Few studies perform follow ups on patent ductus arteriosus (PDA) patients who undergo transcatheter closure. In addition to side effects from the procedure, it is important to evaluate changes in left ventricular function (LVF) parameters and nutritional status. Objective To compare LVF and nutritional status before and during the one-year period post-transcatheter PDA closure, and evaluate potential associated factors in post-closure PDA transcatheter patients. Methods This retrospective cohort study was done in a single center in patients diagnosed with PDA who had undergone transcatheter closure. Data were obtained from subjects’ medical records. The relationship between the post-closure PDA time span and LVF parameters [ejection fraction (EF) and fractional shortening (FS)] was analyzed by Friedman and repeated ANOVA tests; the post-closure PDA time period and nutritional status was analyzed by Friedman test. The time periods analyzed were 1, 3, 6, and 12 months post-closure. Factors potentially associated with LVF 12 months post-closure were analyzed by linear regression. Results A total of 30 patients who had undergone transcatheter PDA closure were included. The body weight mean of at the time of transcatheter PDA closure was 13.1 kg. We found a significant relationship between time period after PDA closure and nutritional status, before and 1, 3, 6, and at 12 months post-closure. In a comparison of pre-closure to 12 months post-closure, subjects’ mean EF (66.6 vs. 70.9%, respectively; P<0.001) and FS (34.4 vs. 37.8%, respectively; P<0.001) were significantly higher. In addition, significantly more patients had normal nutritional status 12 months post-closure than before closure. Age was not related to LVF parameters (EF: r=0.212; P=0.260; FS: r=0.137; P=0.471). Conclusion Both LVF and nutritional status significantly improve gradually over the 12 months post-closure compared to pre-closure. PDA size is not significantly associated with improved LVF parameters and nutritional status.

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confidence: 99%

Time period after transcatheter PDA closure with changes in left ventricular function and nutritional status

Irfan¹,

Ali²,

Tobing³

et al. 2021

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“…However, previous studies have also reported that the median Z-score of the LVEDd was <+2.0 due to pulmonary over-circulation in patients with VSD or PDA and was considered to be an indication for closure. 11, 12 These findings may be problematic due to the low number of cases in previous reports, including ours; however, in some patients with a LV diameter within the normal range, closure is necessary if the measurements are near the upper limit. More data from further studies are needed to clarify this issue.…”

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confidence: 76%

Echocardiographic Left Ventricular Z-Score Utility in Predicting Pulmonary-Systemic Flow Ratio in Children With Ventricular Septal Defect or Patent Ductus Arteriosus

Sumitomo

Kodo

Maeda

et al. 2021

Circ J

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Background:The correlation between the Z-score of the left ventricular (LV) diameter and the LV volume-overload due to pulmonary over-circulation in children with ventricular septal defect (VSD) or patent ductus arteriosus (PDA) remains unclear. Methods and Results:The present, retrospective study enrolled 70 children (aged 0.3-16.8 years; 33 males, 37 females) with a diagnosis of isolated VSD and/or PDA who underwent cardiac catheterization (CC) between 2015 and 2019. Patients with chromosomal/genetic anomalies, growth disorder, right-ventricular enlargement or other conditions causing LV enlargement were excluded. Echocardiographic parameters were retrospectively evaluated from the medical records, converted to a Z-score, then compared with CC data. The pulmonary-systemic flow ratio on CC (cQp/Qs) correlated significantly with the Z-score of both the LV end-diastolic diameter (Zd) (r=0.698, P<0.0001) and LV end-systolic diameter (r=0.593, P<0.0001). Regression analysis and curve-fitting were used to predict the cQp/Qs based on the Zd, and a significant regression equation was found on cubic regression (R 2 of 0.524, P<0.0001) showing a strong correlation with the cQp/Qs (r=0.724, P<0.0001). Conclusions:The Z-score of the LV diameter can be a useful, non-invasive marker for evaluating LV volume overload and determining the surgical indications in children with VSD or PDA because of its strong correlation with the cQp/Qs.

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Predictors for Left Ventricular Systolic Dysfunction and its Outcome after Patent Ductus Arteriosus (Pda) Closure by Device

Cited by 2 publications

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Time period after transcatheter PDA closure with changes in left ventricular function and nutritional status

Time period after transcatheter PDA closure with changes in left ventricular function and nutritional status

Echocardiographic Left Ventricular Z-Score Utility in Predicting Pulmonary-Systemic Flow Ratio in Children With Ventricular Septal Defect or Patent Ductus Arteriosus

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