Predictors of Adherence and Treatment Delays among African American Women Recommended to Receive Breast Cancer Chemotherapy

Gallups, Sarah; Connolly, Mary; Bender, Catherine M.; Rosenzweig, Margaret

doi:10.1016/j.whi.2018.08.001

Cited by 18 publications

(16 citation statements)

References 23 publications

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“…However early recurrence is more frequent in this breast cancer subytpe when compared to others, which usually occurs within the rst 3 years after diagnosis [5,62]. Chemotherapy adherence and uptake have also been shown to differ among patients' racial/ethnic groups [63][64][65][66]. In TNBC, a previous study conducted by our group [67], showed however that although a substantial number of TNBC patients failed to receive and/or complete chemotherapy, AA patients presented a higher chemotherapy uptake than White patients.…”

Section: Discussionmentioning

confidence: 86%

A Panel of miRNAs as Prognostic Markers for African-American Patients with Triple Negative Breast Cancer

Turkistani

Sugita²,

Fadda

et al. 2021

Preprint

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Background: To investigate the global expression profile of miRNAs, their impact on cellular signaling pathways and their association with poor prognostic parameters in African-American (AA) patients with triple negative breast cancer (TNBC).Methods: Twenty-five samples of AA TNBC patients were profiled for global miRNA expression and stratified considering three clinical-pathological parameters: tumor size, lymph node (LN), and recurrence (REC) status. Differential miRNA expression analysis was performed for each parameter, and their discriminatory power was determined by Receiver Operating Characteristic (ROC) curve analysis. KMplotter was assessed to determine the association of the miRNAs with survival, and functional enrichment analysis to determine the main affected pathways and miRNA/mRNA target interactions.Results: A panel of eight, 23 and 27 miRNAs were associated with tumor size, LN, and REC status, respectively. Combined ROC analysis of two (miR-2117, and miR-378c), seven (let-7f-5p, miR-1255b-5p, miR-1268b, miR-200c-3p, miR-520d, miR-527, and miR-518a-5p), and three (miR-1200, miR-1249-3p, and miR-1271-3p) miRNAs showed a robust discriminatory power based on tumor size (AUC=0.917), LN (AUC=0.945) and REC (AUC=0.981) status, respectively. Enrichment pathway analysis revealed their involvement in proteoglycans and glycan, and cancer-associated pathways. Eight miRNAs with deregulated expressions in patients with large tumor size, positive LN metastasis and recurrence were significantly associated with lower survival rates. Conclusions: Altogether, our data indicate that miRNA deregulated expression is a relevant biological factor that can be associated with the poor prognosis in TNBC of AA patients, by conferring to their TNBC cells aggressive phenotypes that are reflected in the clinical characteristics evaluated in this study.

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Section: Discussionmentioning

confidence: 86%

A Panel of miRNAs as Prognostic Markers for African-American Patients with Triple Negative Breast Cancer

Turkistani

Sugita²,

Fadda

et al. 2021

Preprint

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“…From a behavioral perspective, a number of factors may influence the decision to proceed with chemotherapy. Employment status, poor body image, and low emotional support have all been cited as factors contributing to treatment adherence among Black women (23,24). In fact, Black women with ovarian cancer have been shown to have a >50% risk of non-guideline adherent care compared with white women (25).…”

Section: Figure 2 |mentioning

confidence: 99%

Race and Ethnicity Influence Survival Outcomes in Women of Caribbean Nativity With Epithelial Ovarian Cancer

et al. 2020

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Background: Caribbean immigrants represent one of the largest groups of minorities in the United States (US), yet are understudied. Racial and ethnic disparities among women with ovarian cancer have been reported, but not in immigrant populations. Our objective was to evaluate differences in the clinicopathologic features and survival outcomes of Caribbean-born (CB) immigrants with ovarian cancer, with special focus on the influence of race and ethnicity on these measures. Methods: A review of the institutional cancer registry was performed to identify women with known nativity treated for epithelial ovarian cancer between 2005 and 2017. Sociodemographic, clinical, and outcomes data were collected. Analyses were done using chi-square, Cox proportional hazards models, and the Kaplan-Meier method, with significance set at p < 0.05. Results: 529 women were included in the analysis, 248 CB and 281 US-born (USB). CB women were more likely to have residual disease after debulking surgery (31.2 vs. 16.8%, p = 0.009) and be treated at a public facility (62.5 vs. 33.5%, p < 0.001). Black CB women less frequently received chemotherapy compared to White CB women (55.2 vs. 82.2%, p = 0.001). Among all CB women, Hispanic ethnicity was independently associated with improved survival when adjusting for other factors (HR 0.61 [95% CI 0.39-0.95], p = 0.03). White Hispanic CB women had a median overall survival (OS) of 59 months while Black, non-Hispanic CB women had a median OS of 24 months (log-rank p = 0.04). Conclusion: Among Caribbean-born women with ovarian cancer, Hispanic ethnicity is significantly associated with improved survival outcomes, regardless of race.

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“…8 Ketidak patuhan berobat pasien terkhusus pasien kanker payudara yang menjalani kemoterapi dapat menurunkan keberhasilan terapi, menurunkan peluang kelangsungan hidup, meningkatkan angka kejadian masuk rumah sakit, biaya perawatan kesehatan, kejadian kekambuhan, dan angka kematian. 9,10 Definisi kepatuhan berobat menurut buku Adherence to Long-Term Therapies dari WHO tahun 2003, adalah perilaku seseorang minum obat atau menjalani pengobatan, mengikuti diet, dan menjalankan perubahan gaya hidup, sesuai dengan rekomendasi yang disepakati dari penyedia layanan kesehatan yaitu dokter. Kepatuhan merupakan suatu fenomena multidimensi yang dipengaruhi oleh lima faktor, yang disebut juga dengan "The Five Dimentions of Adherence".…”

Section: Pendahuluanunclassified

Faktor-Faktor yang Mempengaruhi Kepatuhan Berobat Pasien Kanker Payudara yang Menjalani Kemoterapi di RSUP Dr. Mohammad Hoesin Palembang

Indah

Qodir

Legiran

2020

Sriwijaya Journal of Medicine

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Kanker payudara berdampak pada 2,1 juta wanita setiap tahun dan menjadi penyebab kematian terbesar kanker pada wanita di dunia. Terapi untuk kanker payudara salah satunya dengan kemoterapi. Dibutuhkan kepatuhan dalam menjalani pengobatan untuk menghindari progresivitas dan kekambuhan penyakit. Jenis penelitian ini adalah deskriptif observasional dengan teknik consecutive sampling. Sampel penelitian ini adalah pasien kanker payudara yang menjalani kemoterapi di RSUP Dr. Mohammad Hoesin pada bulan September 2019 yang memenuhi kriteria inklusi dan ekslusi. Instrumen pada penelitian ini adalah Kuesioner Kepatuhan Pasien Dalam Menjalani Kemoterapi dan kuesionerCenter for Epidemiologic Studies Depression Scale (CES-D). Pada penelitian ini terdapat 49 pasien kanker payudara yang menjadi subjek penelitian. Hasil penelitian pada kelompok terbanyak usia adalah 50-54 tahun dengan persentase 22,4% (n=11), tingkat pendidikan adalah sekolah menengah 42,9% (n=21), dan pendapatan keluarga dibawah UMP 57,1% (n=28). Seluruh subjek (n=49) memiliki asuransi dan efek samping kemoterapi. Menurut penilaian, terdapat 24,5% (n=12) subjek mengalami depresi, 91,8% (n=45) patuh dan tidak patuh berobat sebesar 8,2% (n=4). Alasan patuh berobat adalah keinginan sembuh dan keluarga. Alasan tidak patuh karena jarak rumah yang jauh dan efek samping. Terdapat lima faktor yang mempengaruhi kepatuhan berobat pasien kanker payudara yang menjalani kemoterapi di RSUP Dr.Mohammad Hoesin Palembang, yaitu social and economic, health care team and system, condition, therapy, dan patient-related factors

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Predictors of Adherence and Treatment Delays among African American Women Recommended to Receive Breast Cancer Chemotherapy

Cited by 18 publications

References 23 publications

A Panel of miRNAs as Prognostic Markers for African-American Patients with Triple Negative Breast Cancer

A Panel of miRNAs as Prognostic Markers for African-American Patients with Triple Negative Breast Cancer

Race and Ethnicity Influence Survival Outcomes in Women of Caribbean Nativity With Epithelial Ovarian Cancer

Faktor-Faktor yang Mempengaruhi Kepatuhan Berobat Pasien Kanker Payudara yang Menjalani Kemoterapi di RSUP Dr. Mohammad Hoesin Palembang

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