Predictors of early mortality and sudden death in epilepsy: A multidisciplinary approach

Birnbach, Charles D.; Wilensky, Alan J.; Dodrill, Carl B.

doi:10.1016/0896-6974(91)90116-z

Cited by 21 publications

(8 citation statements)

References 14 publications

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“…However, combinations of different seizure types were more frequent in SUD than in KCD children, whereas the two groups of adults (Schnabel et al 2000) did not differ in this (recalculated: P > 0.1, Fisher test). In agreement with previous observations of epileptic adults (Birnbach et al 1991;Nilsson et al 1999;Schnabel et al 2000), primarily and secondarily generalized seizures including tonic-clonic seizures, were not more frequent in SUD than in KCD children. The West syndrome was not exhibited by a higher proportion of the SUD children than in the control group.…”

Section: Discussionsupporting

confidence: 92%

Are geomagnetic disturbances a risk factor for the sudden unexplained death of epileptic children?

Schnabel

May²,

Beblo

et al. 2003

International Journal of Biometeorology

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The relationship between geomagnetic disturbances (with amplitudes above 50 nT) and the sudden unexplained death (SUD) of epileptic adults has been controversial up to now. In an autopsy-based cohort study (from 1964 to 1992) 15 epileptic children with SUD aged 1-14 years were compared to 63 epileptic children whose cause of death was known (KCD). The time of death as well as two international geomagnetic indices were assessed: Bartels' planetary 3-h signs (Kp) for the time of death and 2 h before, and the mean planetary daily amplitudes (Ap) on the day of death and on the 4 critical days before (and on the 4 post-mortem days as a control). Among the 15 SUD patients 9 died between 6 a.m. and 9 a.m. (universal time) whereas the KCD group showed an approximately uniform distribution of the time of death ( P = 0.026, Kolmogorov-Smirnov test). The Kp signs at death and 2 h before as well as the Ap indices at death and for the 4 pre-mortem days or after were not different in comparisons between the SUD and the KCD group ( P > 0.2, Mann-Whitney test). Furthermore the frequency of sudden storm commencement at death and for the 4 days before revealed no deviation of the SUD (26.7%) from the KCD group (23.8%) ( P > 0.2, Fisher test). The results do not support the hypothesis that geomagnetic disturbances are a risk factor for the sudden unexplained death of epileptic children.

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Section: Discussionsupporting

confidence: 92%

Are geomagnetic disturbances a risk factor for the sudden unexplained death of epileptic children?

Schnabel

May²,

Beblo

et al. 2003

International Journal of Biometeorology

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“…Although three patients presented GTCS in our study, these seizures were isolated and no SUDEP cases were found. Following this reasoning, our results are totally in agreement with the elegant study of Birnbach and colleagues that comparing people with epilepsy who died with those who survived, described that majority of those who died had a history of GTSC and that the frequency of GTCS was greater in those who died 26 . Finally, age is another interesting risk factor for SUDEP that could be explored in our study.…”

Section: Discussionsupporting

confidence: 82%

Is there something special about cardiovascular abnormalities and sudden unexpected death in epilepsy among patients with chronic renal insufficiency in regular hemodialysis program?

Gomes

Kesrouani

Cruz

et al. 2009

Arq. Neuro-Psiquiatr.

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-Of the many risk factors suggested for sudden unexpected death in epilepsy (SUDEP), higher frequency of seizures is a very consistent issue. Following this reasoning, it has been established that hemodialysis-associated seizure is a complication of dialysis procedure. Based on these facts, this study investigated a possible association between cardiovascular abnormalities and SUDEP among patients with chronic renal insufficiency in regular hemodialysis program. For that, a retrospective medical history of 209 patients was reviewed to investigate the occurrence of convulsive seizures and EKG abnormalities during dialytic program. Three patients presented generalized tonic-clonic seizures, one had partial seizure with secondary generalization, and one presented unclassified seizure. Any EKG abnormalities and SUDEP event were found in all patients evaluated. In conclusion, the present findings demonstrated uncommon the occurrence of seizures and also SUDEP. Probably, the main justification to not allow us to demonstrated a direct relation between SUDEP and cardiovascular diseases in hemodialysis are the reduced number of cases examined.KEy wOrDS: epilepsy, sudden death, heart, seizure, hemodialysis.Existe algo de especial a respeito das anormalidades cardíacas e morte súbita e inesperada na epilepsia nos pacientes com insuficiência renal crônica no programa regular de hemodiálise?Resumo -Um dos principais fatores de risco para a morte súbita e inesperada na epilepsia (SUDEP) é a alta freqüência de crises epilépticas. Seguindo este raciocínio, tem sido estabelecido que as crises epilépticas associadas à hemodiálise seja uma complicação do procedimento dialítico. Baseado neste fato, este estudo investigou uma possível associação entre anormalidades cardiovasculares e SUDEP nos pacientes com insuficiência renal crônica em um programa regular de hemodiálise. Para isto, um histórico médico retrospectivo de 209 pacientes foi revisado para avaliar a ocorrência de crises epilépticas e possíveis anormalidades no ECG durante o programa de diálise. Três pacientes apresentaram crises tônico-clonica generalizadas, um apresentou crise parcial com generalização secundária e um apresentou crise não-classificada. Não detectamos anormalidades no ECG e ocorrência de SUDEP em todos os pacientes avaliados. Em conclusão, na presente amostra constatou-se como rara a ocorrência de crises epilépticas e SUDEP. Provavelmente, o número reduzido de casos avaliados tenha sido responsável pela não observação de uma relação direta entre SUDEP e as doenças cardiovasculares na hemodiálise.

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“…16,23,[25][26][27][28][29][30][31][32]56 The remit of comment and investigation of SMR of risk factors of these 10 studies was ambiguous and diverse. Some articles commented on epilepsy SMR in people without ID and some reported on epilepsy SMR in the background of ID or CP or neurological damages.…”

Section: Resultsmentioning

confidence: 95%

“…18,22 Seven studies commented on the type of ID. 18,[22][23][24][25][26][27] One used the definition, 'Intelligent quotient less than 70' 18 and another classified ID as 'severe or profound'. 22 The remaining studies used terms like 'neurological deficit', 22 'enrolled at a residential school' 25 or 'neurodeficit' defined as mental retardation, cerebral palsy, hypotonia, 26 etc.…”

Section: Resultsmentioning

confidence: 99%

Does intellectual disability increase sudden unexpected death in epilepsy (SUDEP) risk?

Young

Shankar

Palmer

et al. 2015

Seizure

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Predictors of early mortality and sudden death in epilepsy: A multidisciplinary approach

Cited by 21 publications

References 14 publications

Are geomagnetic disturbances a risk factor for the sudden unexplained death of epileptic children?

Are geomagnetic disturbances a risk factor for the sudden unexplained death of epileptic children?

Is there something special about cardiovascular abnormalities and sudden unexpected death in epilepsy among patients with chronic renal insufficiency in regular hemodialysis program?

Does intellectual disability increase sudden unexpected death in epilepsy (SUDEP) risk?

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