Predictors of weight loss and maintenance in patients treated with antiobesity drugs

Abstract

Background:The prevalence of obesity and related diseases has increased enormously in the last few decades, becoming a very important medical and social issue. Because of the increasing number of people who need weight loss therapies and the high costs associated with these, the search for reliable predictors of success for weight loss and weight maintenance treatments has become a priority.Objective:A literature review was undertaken to identify possible predictors of outcome of weight loss and weight maintenance in patients treated with antiobesity drugs.Results:For the majority of variables, published data are not sufficient to define their role on final outcomes. Among all considered factors, only early response to treatment appeared to be a reliable positive predictor, and diabetes a negative predictor of weight loss and maintenance.Conclusion:To date, no definitive results have been obtained. Due to the great benefits of reliable predictors of outcome associated to currently available antiobesity drugs and those under development, identifying these predictors has to be supported and encouraged.

An energy‐reduced dietary pattern, including moderate protein and increased nonfat dairy intake combined with walking promotes beneficial body composition and metabolic changes in women with excess adiposity: a randomized comparative trial

“…1992; Guaraldi et al. 2011) and maintenance of BW loss over time (Wadden et al. 1992; Jeffery et al.…”

“…1998; Stotland and Larocque 2005; Guaraldi et al. 2011) provided that early BW loss is significant and followed by lifestyle changes that are monitored over time (Toubro and Astrup 1997; Astrup and Rössner 2000). Estimated energy intake was significantly lower in the INT group compared to the CON group, and though not significant at P  < 0.01 in the context of the entire intervention, BW (and body mass index) was reduced to a greater extent ( P  < 0.01) in the INT group than the COM group at Week 2 (−2.4 ± 1.0 vs. −1.7 ± 1.1 kg).…”

“…In the current study, the JumpStart phase was designed to accelerate BW loss within the INT group. Interventions show that a more substantial initial BW loss (within the first 5-12 weeks) predicts overall BW loss (Wadden et al 1992;Guaraldi et al 2011) and maintenance of BW loss over time (Wadden et al 1992;Jeffery et al 1998;Stotland and Larocque 2005;Guaraldi et al 2011) provided that early BW loss is significant and followed by lifestyle changes that are monitored over time (Toubro and Astrup 1997;Astrup and Rössner 2000). Estimated energy intake was significantly lower in the INT group compared to the CON group, and though not significant at P < 0.01 in the context of the entire intervention, BW (and body mass index) was reduced to a greater extent (P < 0.01) in the INT group than the COM group at Week 2 (−2.4 ± 1.0 vs. −1.7 ± 1.1 kg).…”

“…Estimated energy intake was significantly lower in the INT group compared to the CON group, and though not significant at P < 0.01 in the context of the entire intervention, BW (and body mass index) was reduced to a greater extent (P < 0.01) in the INT group than the COM group at Week 2 (−2.4 ± 1.0 vs. −1.7 ± 1.1 kg). The 2-week JumpStart phase may not have been sufficient in length to induce significant differences in BW loss (at P < 0.01) between groups as part of the entire 12-week weight-loss phase plus 12-week weight-loss maintenance phase (Wadden et al 1992;Stotland and Larocque 2005;Guaraldi et al 2011).…”

Gastric Electrical Stimulation for the Treatment of Obesity: From Entrainment to Bezoars—A Functional Review

“…Due to the strong dependency of diets on individual particularities, personal dietetic management was recommended for this weight loss strategy [14]. For the purposes of effective counseling, objective weight loss predictors for individuals on specific dietary plans are under exploration [15]. …”