Predisposition to Diabetes as Evaluated by the Cortisone-Glucose Tolerance Test in Children: A Preliminary Study

Wajchenberg, B. L.; Pupo, A A; Quintão, Eder Rocha; León, Nuevo; Saldanha, P. H.

doi:10.2337/diab.13.6.569

Cited by 9 publications

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“…In the present study the recommendation of Wajchenberg et al 5 was followed. These authors performed CGTT's with progressively increasing doses of cortisone in control children and children with one or both parents diabetic.…”

Section: Discussionmentioning

confidence: 95%

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Capillary Blood Sugar Values in Children During the Oral Cortisone-Primed Glucose Tolerance Test

1971

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Three-hour oral cortisone-primed glucose tolerance tests were performed on a total of 113 children in three age groups; iy 2 to less than 4 yrs., 4 yrs. to less than 8 yrs., and 8 to 12 yrs. of age. All children had negative family histories for diabetes, were in good health, and had recent normal oral glucose tolerance tests. A capillary blood microtechnic for blood sugar was used. Oral glucose was administered according to age and weight. The total cortisone dosage was 280 mg. per M 2 given in two equally divided doses eight-and-one-half and two hours before the testing.It is suggested that the blood sugar values for the IV2 to less than 4 yrs. age group be considered separately because of significant differences from the other age groups. The values for the ± 2 standard deviation range for boys and girls from 4 to 12 yrs. of age were: fasting (54.4-114.0 mg./ 100 ml.); 30 min. (96.1-202.9 mg./lOO ml.); 60 min. (74.7-202.3 mg./lOO ml.); 90 min. (72.5-169.3 mg./lOO ml.); 120 min. (65.8-157.4 mg./lOO ml.) ; 180 min. (49.6-122.4 mg./100 ml.). DIABETES 20:615-21, September, 1971.The thrust of much present day research is to identify those individuals predisposed to diabetes mellitus 1 and to evaluate the effectiveness of early therapy. 2 -3 The evidence for the importance of genetic factors in diabetes 4 has resulted in an increasingly large number of children being examined for the presence of the disease.Probably the most widely used test in studies of the prevalence of diabetes has been the oral glucose tolerance

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Section: Discussionmentioning

confidence: 95%

“…This dosage corresponds to the pharmacologic dose of 75 to 300 mg. per M 2 per twenty-four hours recommended by Nelson. 21 Wajchenberg et al 5 administered a glucose load of 1.75 gm./kg. ideal body weight.…”

Section: Discussionmentioning

confidence: 99%

Capillary Blood Sugar Values in Children During the Oral Cortisone-Primed Glucose Tolerance Test

1971

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“…The intravenous glucose tolerance test is not as sensitive as the oral test for detection of chemical diabetes in children. Studies of insulin and growth hormone response to maximal stimulation with intravenous glucose, 13 tolbutamide 14 and glucagon; 15 free fatty acid response to oral and IV glucose; 13 cortisone-primed glucose tolerance testing; 16 and morphological studies of microvasculature are of interest in investigating groups of patients but are not yet of diagnostic value in individual children.…”

Section: Definitionmentioning

confidence: 99%

Chemical Diabetes Mellitus in Childhood: Report of a Conference

1972

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The recognition of chemical diabetes mellitus in children has led to questions of diagnostic criteria, methodology of testing, choice of populations to study and possible therapeutic approaches to the prevention of progression to overt (insulin-dependent) diabetes. Since the natural history of chemical diabetes in children includes spontaneous improvement as well as stability or progression of glucose intolerance, evaluation of the significance of abnormality and the effect of potential therapy is difficult. The oral glucose tolerance test (OGTT), despite problems in interpretation and methodology, remains the only generally accepted test for chemical diabetes in children. Criteria for interpretation of the OGTT in children used by pediatric investigators are similar to the Fajans and Conn standards for adults. Application of these criteria to certain high risk groups, including obese children, children with mild symptoms suggestive of hypoglycemia, and siblings of those with overt diabetes, has permitted the identification of 200 children with this stage of diabetes. Approximately 11 per cent have progressed to insulin dependency during one to seventeen years of observation. Data on treatment of these patients is limited to anecdotal reports or summaries of small groups of patients treated for variable periods with sulfonylurea drugs. It is not possible to recommend a therapeutic program for children with chemical diabetes, except in the case of the overweight child, where diet restriction may be as efficacious as in adults. Thus, testing of high risk persons and attempts at treatment should only be undertaken in an investigational setting. DIABETES 2i: 45-49, January, 1972. The conference was organized to exchange information on the identification and management of chemical diabetes in children in an attempt to establish recommendations for diagnostic criteria, methodology, populations to study and therapeutic investigation. Thirtytwo papers were presented and will be published as proceedings. 1 The following is a synthesis and summary of each of the four conference sessions.

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The Study of Carbohydrate Metabolism

Foà¹,

Grillo²

1966

Erzeugung Von Krankheitszuständen Durch Das Experiment

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Predisposition to Diabetes as Evaluated by the Cortisone-Glucose Tolerance Test in Children: A Preliminary Study

Cited by 9 publications

References 0 publications

Capillary Blood Sugar Values in Children During the Oral Cortisone-Primed Glucose Tolerance Test

Capillary Blood Sugar Values in Children During the Oral Cortisone-Primed Glucose Tolerance Test

Chemical Diabetes Mellitus in Childhood: Report of a Conference

The Study of Carbohydrate Metabolism

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