Preeclampsia and depression: a case–control study in Tehran

Kharaghani, Roghieh; Geranmaye, Mehrnaz; Janani, Leila; Hantooshzade, Sedighe; Arbabi, Mohammad; Bilandi, Roghaieh Rahmani; Bagheri, Fatemeh

doi:10.1007/s00404-012-2260-3

Cited by 39 publications

(36 citation statements)

References 16 publications

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“…Among seven of these studies, five were positive [32][33][34][35][36] and two were negative; 21,23 since most did not inquire about the prepregnancy period, there is no way to know whether depression/anxiety symptoms and/or diagnoses during pregnancy represented a preexisting chronic problem. One exception was a study that used interview and prenatal records to ascertain depression/anxiety diagnosis during and prior to pregnancy and reported no association with PE for the latter.…”

Section: Discussionmentioning

confidence: 99%

Association Between Pre-Pregnancy Depression/Anxiety Symptoms and Hypertensive Disorders of Pregnancy

Thombre

Talge

Holzman

2015

Journal of Women's Health

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Background: Depression and anxiety symptoms have been linked with hypertensive disorders during pregnancy, but these associations have not been fully elucidated. Our objective was to consider hypertension in pregnancy and its subtypes (chronic hypertension, gestational hypertension, preeclampsia) and evaluate whether the proximity of psychological symptoms to pregnancy informs any associations observed. Methods: Pregnancy Outcomes and Community Health Study participants who provided interview data at enrollment (16-27 weeks' gestation) and whose hypertensive disorder status was abstracted from medical records were eligible for inclusion (n = 1371). Maternal history of depression/anxiety symptoms at four time points in the life course were ascertained via self-report at enrollment (i.e., lifetime history, 1 year prior to pregnancy, since last menstrual period, and past week). Weighted logistic regression models were used to examine depression/anxiety symptom measures in relation to hypertensive disorders (overall) and subtype. Results: Following adjustment for maternal sociodemographic factors, smoking, and prepregnancy body mass index, prepregnancy depression or anxiety symptoms (i.e., lifetime history and 1 year prior to pregnancy) were associated with hypertensive disorders during pregnancy. Subtype analyses revealed that these associations were driven primarily by chronic hypertension (adjusted odds ratios = 2.7-3.5). Preeclampsia accompanied by preterm delivery was also linked to women's lifetime history of depression symptoms (odds ratio = 2.3, 95% confidence interval 1.0-5.2). Conclusion: Our results suggest that the link between maternal chronic hypertension and depression/anxiety symptoms precedes pregnancy. In addition, prepregnancy history of depression/anxiety symptoms may be considered part of a risk profile for preterm preeclampsia.

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Section: Discussionmentioning

confidence: 99%

Association Between Pre-Pregnancy Depression/Anxiety Symptoms and Hypertensive Disorders of Pregnancy

Thombre

Talge

Holzman

2015

Journal of Women's Health

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“…29 Our results are higher than in most studies found in the literature. 22,26 The difficult social conditions of the populations could be the common feature of these studies. Preeclampsia will occur in women already in a precarious social situation.…”

Section: Discussionmentioning

confidence: 99%

“…For each item, we assigned a score of 0, 1, 2, and 3, to the response categories of 'not at all', 'several days', 'more Authors obtained the total by adding together the scores for the nine questions. With a possible total score of 27, patients were classified as absence of depression (PHQ-9 score: 0-4), mild depression (PHQ-9 score: 5-9), moderate depression (PHQ-9 score: 10-14), moderately severe depression (PHQ-9 score: 15-19), or severe depression (PHQ-9 score: [20][21][22][23][24][25][26][27]. At the end of it all, patients who scored ≥10 suggestive of anxiety as well as depressive disorders were referred for appropriate psychiatric care.…”

Section: Methodsmentioning

confidence: 99%

“…21 Kharaghani et al in Tehran, Iran reported the prevalence of moderate to severe depression in preeclamptic women as 31.2% during pregnancy. 22 In order to document the perinatal frequency of anxiety and depression disorders in women with hypertensive pregnancy disorders in our setting, we decided to carry out this study. It was our intention to determine disease prevalence and to define the socio-demographic and obstetrical characteristics of these patients.…”

mentioning

confidence: 99%

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GAD-7 and PHQ-9 measurement of perinatal anxiety and depression in women with hypertensive disorders of pregnancy in Yaounde, Cameroon

Essiben

Ojong

et al. 2018

Int J Reprod Contracept Obstet Gynecol

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Background: The aim of the study was to determine the prevalence of perinatal anxiety and depression in women with hypertensive diseases during pregnancy in Yaounde.Methods: Authors carried out a cross-sectional descriptive study over nine months from October 2015 to May 2016, amongst pregnant women with hypertensive pregnancy disorders followed up in three tertiary care centers in Yaounde. Authors collected information from the medical files of selected patients by using a pre-tested and validated questionnaire in the perinatal period. We classified blood pressure values as per the JNC 7 recommendations. Anxiety and mental depression were evaluated for using the Generalized Anxiety Disorder 7-item and the Patient Health Questionnaires-9 respectively. Data analysis was done using CSPro version 6.2 and SPSS version 20.0 software.Results: Authors included 202 patients during the study period. The mean age stood at 25.9± 6.4years (extremes 13-43years). Amongst these, 47.5% were single while 97.5% (197/202) had received at least primary education. Students represented 45.5% (92/202) of women while 102 (50.5%) of them had some form of employment in the public, private or informal sectors. Severe preeclampsia was the most prevalent hypertensive disorder in these women, with 69 (34.2%) developing eclampsia. We found that 79% (161/202) of these patients suffered from anxiety, 67.3% (136/202) were depressive while 61.3% (124/202) had both anxiety and depression.Conclusions: The prevalence of perinatal anxiety and depression in women with hypertensive pregnancy disorders is high. Associated factors must be looked out in order to prevent these situations.

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“…Qiu és mtsai vizsgálati eredményei szerint a terhességük alatt mérsékelt depressziós tüneteket mutató nőknek 2,3-szer, a súlyo-sabb tüneteket mutatóknak 3,2-szer nagyobb kockáza-tuk volt a praeeclampsia kialakulására [29]. Kharaghani és mtsai kutatásában a középsúlyos, illetve súlyos depresszióval diagnosztizált nők 2,5-szer nagyobb valószí-nűséggel lettek praeeclampsiásak várandósságuk során [30]. Továbbá, az anya kór történetében szereplő koráb-bi pszichiátriai zavarok -különös tekintettel a depressziós és szorongásos kór képekre -szintén megnövelhetik a praeeclampsia kialakulásának esélyét [31].…”

Section: A Pszichés Faktorok Vizsgálata Praeeclampsiábanunclassified

A praeeclampsia pszichoszociális vonatkozásai

2015

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A praeeclampsia kialakulásához egyes esetekben pszichés faktorok is hozzájárulhatnak neuroendokrin és immunoló-giai mechanizmusok közvetítése révén, amelyek közül kiemelhető a hypothalamus-hypophysis-mellékvesekéreg tengely aktivitásának fokozódása és a proinfl ammatorikus citokinek szérumszintjének emelkedése. A praeeclampsia egyes pszichés zavarok előfordulását is megnöveli, a hosszan tartó hospitalizáció, a kontrollvesztés érzése, a koraszülés vagy a magzat egészségkárosodása következtében. Emellett a kórkép tartósan fennálló neurokognitív panaszokat okozhat, amelyek szintén negatívan befolyásolhatják az életminőséget. Tekintettel arra, hogy az anya rossz mentális állapota a terhesség kimenetelét és a magzat fejlődését egyaránt károsan befolyásolhatja, a praeeclampsiás nők számára a pszichológiai segítségnyújtás előnyös lehet. Orv. Hetil., 2015, 156(50), 2028-2034. Kulcsszavak: praeeclampsia, terhesség, depresszió, hypothalamus-hypophysis-mellékvesekéreg tengely, pszichoterápia Psychosocial aspects of preeclampsiaDistress conditions during pregnancy may contribute to the development of preeclampsia by altering functions of the neuroendocrine and immune systems, e.g. activation of the hypothalamic-pituitary-adrenal axis and increase in plasma proinfl ammatory cytokines. Preeclampsia may also precipitate mental health problems due to long-term hospitalization or unpredictable and uncontrollable events such as preterm labor and newborn complications. Besides, preeclampsia may induce persistent neurocognitive complaints with a negative impact on patients' quality of life. As growing evidence indicates that poor maternal mental health has an adverse effect on pregnancy outcome and fetal development, psychosocial interventions may be benefi cial for women with preeclampsia. Rövidítések 11β-HSD2 = 11-béta-hidroxiszteroid-dehidrogenáz-2 izoenzim; ACTH = adrenokortikotrop hormon; CRH = corticotropin releasing hormon; EMDR = eye movement desensitization and reprocessing; HPA = hypothalamus-hypophysis-mellékve-sekéreg tengely; PPD = postpartum depresszió; PTSD = poszttraumás stressz zavar; SNRI = (selective serotonin-norepinephrine reuptake inhibitor) szelektív szerotonin-noradrenalin visszavételgátló; SSRI = (selective serotonin reuptake inhibitor) szelektív szerotoninvisszavétel-gátló A praeeclampsia a terhességek 5-8%-ában fellépő súlyos szövődmény, amely hypertoniában, vizeletfehérje-ürítés-ben nyilvánul meg. Jellemzően a terhesség második vagy harmadik trimeszterében jelentkezik, és az anyai és magzati mortalitás és morbiditás egyik vezető oka világ szerte. A kórkép patogenezise nem teljesen tisztázott. A praeeclampsia kialakulásában a placentáció zavara fontos szerepet játszik a terhesség korai szakaszában [1]. A rossz vérellátású, ezáltal hypoxiás placenta olyan faktorokat

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Preeclampsia and depression: a case–control study in Tehran

Abstract: With regard to the high prevalence of moderate to severe depression and its association with preeclampsia, our findings support and suggest efforts for screening depression among pregnant women and appropriate educational studies for mental and psychological problems during pregnancy.

Cited by 39 publications

References 16 publications

Association Between Pre-Pregnancy Depression/Anxiety Symptoms and Hypertensive Disorders of Pregnancy

Association Between Pre-Pregnancy Depression/Anxiety Symptoms and Hypertensive Disorders of Pregnancy

GAD-7 and PHQ-9 measurement of perinatal anxiety and depression in women with hypertensive disorders of pregnancy in Yaounde, Cameroon

A praeeclampsia pszichoszociális vonatkozásai

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