Preemptive analgesic effect of systemically administered midazolam: experimental study in rats

Hasani, Antigona; Soljakova, Marija; Jakupi, M

doi:10.1097/00003643-201206001-00442

Cited by 5 publications

(6 citation statements)

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“…This may mean that Cataflam and Cannabis do not have an effect on acute thermal pain. However this is not in agreement with the findings of Hasani et al (27) who observed an anti-nociceptive effect of Diclofenac in Formalin test. Interestingly, there was a significant reduction in duration and frequency of right hind paw lick in the group treated with Diclofenac in phase one of the formalin test.…”

Section: Discussioncontrasting

confidence: 99%

“…Edwards et al (26) established the efficacy of aspirin as a post-operative analgesic. A study by Hasani et al (27) shows that Cataflam (Diclofenac) has preemptive and anti-nociceptive effects in acute thermal and inflammatory induced pain. However, when we compared the degree of reduction in the sensitivity to pain by the three test substances (Aspirin, cataflam and Cannabis) we found no significant difference of cannabis compared to aspirin and cataflam.…”

Section: Discussionmentioning

confidence: 99%

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Comparative Effect of Cannabis, Aspirin and Cataflam on Nociception in Cd1 Mice

Nku¹,

Oghale²,

Ajiwhen³

2014

IOSRJPBS

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Comparative Effect of Cannabis, Aspirin and Cataflam on Nociception in Cd1 Mice

Nku¹,

Oghale²,

Ajiwhen³

2014

IOSRJPBS

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“…The Randall-Selitto test was used to assess the analgesic effect of the test objects [24] under the development of inflammatory hyperalgesia in rats [25]. At the beginning of the experiment, the baseline of pain threshold (PT) was measured in all rats using the analgesimeter Ugo Basile 37215 by stimulating pain reaction on the right hind paw [26].…”

Section: Analgesia Experimentsmentioning

confidence: 99%

Pharmacological and biopharmaceutical studies of paracetamol and N-acetyl-D-glucosamine combination as an analgetic drug

Рубан

Zupanets

Kolisnyk

et al. 2022

SR: PS

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The aim. Experimental selection of paracetamol and N-acetyl-D-glucosamine (NAG) ratio and combined dose and bioavailability study of the pharmaceutical composition and active pharmaceutical ingredient (API) in the model of cell biomembranes. Materials and methods. The following substances were used: paracetamol, Actimask Acetaminophen (gelatin-coated paracetamol), and NAG. For pharmacological studies were used laboratory rats, which received test objects intragastrically. The study was performed on the model of inflammatory hyperalgesia according to the Randall-Selitto method. The values of pain threshold before and after pathology induction were established. For biopharmaceutical studies, dry L-α-dimyristoylphosphatidylcholine purchased from Avanti Polar Lipids (purity 99.9 %) was used, hydrated with an appropriate amount of double-distilled water to obtain 70 % wt./wt. water dispersion. Differential scanning calorimetry (DSC) studies were performed employing DSC 1 microcalorimeter (Mettler Toledo). Pharmaceuticals investigated were placed on the bottom of a crucible, then a proper amount of the lipid membrane was added and this moment was taken as the time reference point (t=0). Then a crucible was sealed with a lid and a sample was undergone consecutive temperature scans, heating from 0 to 35 ºC at a scanning rate of 2 ºC/min. The procedure was repeated until no more changes in DSC profiles were observed, i.e. system equilibrium was reached. Results. It has been experimentally proven that the combination of paracetamol and NAG in the ratio of 4:1 showed better analgesic efficacy. The dose of active ingredients was determined to be 50 mg/kg by the sum of API. The active interaction of paracetamol with the bilayer of biomembranes was established and it was determined that Actimask has a worse rate of penetration into the membrane due to the coating of paracetamol with a gelatin shell. NAG didn't significantly affect the rate of penetration of Actimask through the bilayer of membranes, but the auxiliary components of the tablet mixture significantly improved the rate and completeness of penetration of paracetamol through the bilayer of biomembranes. Conclusions. The study found the most effective ratio between paracetamol and NAG in the composition, which is 4:1. The next step was to determine the dose of API, which is 50 mg/kg of the sum of active substances. It has been determined that paracetamol has good permeability through the bilayer of biomembranes, and the tablet mass significantly improves the permeability of paracetamol

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“…Although there are reports on the usefulness of preemptive analgesia in animal models [17] , [18] , its clinical efficacy remains debatable. Previous reviews of Moiniche [19] and Dahl [20] concluded that although in some studies it appeared to be effective, preemptive analgesia generally was not superior to postoperative pain relief in terms of reduced pain scores.…”

Section: Accepted M Manuscriptmentioning

confidence: 99%

A single preoperative dose of diclofenac reduces the intensity of acute postcraniotomy headache and decreases analgesic requirements over five postoperative days in adults: A single center, randomized, blinded trial

Molnár¹,

Simon²,

Kazup³

et al. 2015

Journal of the Neurological Sciences

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A single preoperative dose of diclofenac reduces the intensity of acute postcraniotomy headache and decreases analgesic requirements over five postoperative days in adults: a single center, randomized, blinded trial This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. KTIA_13_NAP-A-II/5. None of the authors has a personal financial interest in this research. A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT 2 AbstractObjective: Postcraniotomy headache causes considerable pain and can be difficult to treat. We therefore tested the hypothesis that a single 100-mg preoperative dose of diclofenac reduces the intensity of postcraniotomy headache, and reduces analgesic requirements.Methods: 200 patients having elective craniotomies were randomly assigned to diclofenac (n=100) or control (n=100). Pain severity was assessed by an independent observer using a 10-cm-long visual analogue scale the evening of surgery, and on the 1st and 5th postoperative days. Analgesics given during the first five postoperative days were converted to intramuscular morphine equivalents.Results were compared using Mann-Whitney-tests; P<0.05 was considered statistically significant.Results: Baseline and surgical characteristics were comparable in the diclofenac and control groups. Visual analogue pain scores were slightly, but significantly lower with diclofenac at all times (means and 95% confidence intervals): the evening of surgery, 2.47 (1.8-3.1) vs. 4. 37(5.0-3.7), (P<0.001); first postoperative day, 3.98 (3.4-4.6) vs.5.6 (4.9-6.2) cm (P<0.001) and 5th postoperative day: 2.8 (2.2-3.4) vs. 4.0 ± (3.3-4.7) cm (P = 0.013). Diclofenac reduced systemic analgesic requirements over the initial five postoperative days (mean and 95% CI): 3.3 (2.6 -3.9) vs. 4.3 (3.5-5.1) mg morphine equivalents (p<0.05). Conclusions: Preoperative diclofenac administration reduces postcraniotomyheadache and postoperative analgesic requirements -a benefit that persisted throughout five postoperative days.

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Preemptive analgesic effect of systemically administered midazolam: experimental study in rats

Cited by 5 publications

References 0 publications

Comparative Effect of Cannabis, Aspirin and Cataflam on Nociception in Cd1 Mice

Comparative Effect of Cannabis, Aspirin and Cataflam on Nociception in Cd1 Mice

Pharmacological and biopharmaceutical studies of paracetamol and N-acetyl-D-glucosamine combination as an analgetic drug

A single preoperative dose of diclofenac reduces the intensity of acute postcraniotomy headache and decreases analgesic requirements over five postoperative days in adults: A single center, randomized, blinded trial

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