Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics

Taha, Mona M.; Mahdy-Abdallah, Heba; Shahy, Eman M.; Mansour, N.; Fouad, Mohamed; Helmy, Mona

doi:10.1515/jcim-2021-0511

Cited by 2 publications

(1 citation statement)

References 29 publications

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“…This experimental study shows that with the increase of Hcy level, the prevalence of DPN gradually increases, and plasma Hcy is related to abnormal nerve conduction velocity. This is consistent with previous studies [ 26 , 27 ]. When Hcy > 15 μ mmo/L, the nerve conduction velocity obviously decreases with the increase of Hcy, and there is a significant correlation between the two [ 21 , 28 ].…”

Section: Discussionsupporting

confidence: 94%

A Retrospective Study on the Time in Range of Blood Glucose and Type 2 Diabetic Peripheral Neuropathy

Chang

et al. 2022

BioMed Research International

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Background. Time in range (TIR) is one of the basic indicators to assess glycemic control. In this study, the TIR of DPN patients was used as the observation index to further evaluate the correlation between TIR and DPN, so as to provide new ideas for preventing the occurrence of DPN and delaying its disease progression. Methods. A total of 120 patients with T2DM (T2DM) who were hospitalized in the Endocrinology Department of our hospital from October 2018 to February 2020 were included and divided into two groups according to whether the nerve conduction velocity was normal or not, the diabetic peripheral neuropathy group (DPN) and the other groups. No diabetic peripheral neuropathy group (NDPN). According to the corresponding inclusion and exclusion criteria, the baseline data were recorded, and test indicators such as homocysteine and blood lipids were collected at the same time, and TIR was collected by a transient blood glucose meter. To explore the relationship between TIR and other indicators and peripheral neuropathy in T2DM. Results. A total of 120 T2DM patients participated in the study, including 82 in the DPN group and 38 in the NDPN group. There were no statistically significant differences in basic indicators such as age, height, and weight between the two groups. Glycated hemoglobin (HbA1c) and homocysteine (Hcy) in DPN group were higher than those in NDPN group, while TIR and HDL-C were lower than those in NDPN group ( P < 0.05 ). Logistic regression analysis showed that HbA1c and Hcy were risk factors for DPN, and TIR and HDL-C were protective factors for DPN, with statistical significance ( P < 0.05 ). The prediction results of TIR, Hcy, HDL-C, and HbA1c on diabetic peripheral neuropathy were analyzed by ROC curve, and the prediction results of the five variables were all statistically significant ( P < 0.05 ) and have a better prediction effect. Conclusion. (1) The results of TIR level suggest that the longer the blood sugar is in the good control range, the more beneficial it is to reduce the occurrence of DPN. (2) TIR and HDL-C are protective factors for DPN, and HbA1c and Hcy are risk factors for DPN. (3) The results of ROC curve analysis showed that TIR, Hcy, HbA1c, and HDL-C had a good predictive effect on the occurrence of DPN.

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Section: Discussionsupporting

confidence: 94%

A Retrospective Study on the Time in Range of Blood Glucose and Type 2 Diabetic Peripheral Neuropathy

Chang

et al. 2022

BioMed Research International

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Elevated Homocysteine Levels and Vitamin Deficiencies as Potential Risk Markers for Coronary Artery Disease in Apparently Healthy Adults

Sowndarya,

Hegde,

Pawar

et al. 2024

Biomedical and Biotechnology Research Journal

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Background: Hyperhomocysteinemia (HHcy) is proposed as a risk factor for coronary artery disease (CAD), while dyslipidemia is a well-established risk factor. HHcy can arise from deficiencies in Vitamin B12 (Vit B), Vitamin B6, and folic acid (FA), as well as from kidney diseases or genetic factors. This study aims to evaluate homocysteine (Hcy) levels as potential predictors of CAD risk in apparently healthy adults. Methods: A cross-sectional analytical study was conducted with 62 healthy individuals aged 20–62 years visiting a tertiary healthcare center for routine health checks. After obtaining ethical clearance and informed consent, serum Hcy levels, fasting lipid profiles (total cholesterol, triglycerides, high-density lipoprotein, and low-density lipoprotein), Vit B12, and FA levels were measured using standard laboratory techniques. Statistical analyses were conducted using SPSS version 20. Results: HHcy was detected in 43.54% of participants, with 59% of those exhibiting either isolated or combined vitamin deficiencies. A significant negative correlation was found between Hcy levels and both Vit B12 and FA (P < 0.001). Notably, there was no significant correlation between Hcy levels and traditional lipid profile markers. Conclusion: The findings indicate that apparently healthy adults can have elevated Hcy levels significantly associated with Vit B12 and FA status, but not with conventional CAD risk markers such as lipid profiles. These results suggest the need for further investigation into Hcy as a viable alternative marker for CAD risk in young adults, emphasizing the importance of monitoring vitamin levels to mitigate cardiovascular risks.

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Preference between serum homocysteine and urinary periostin as early predictive biomarkers of renal dysfunction among uncontrolled diabetics

Cited by 2 publications

References 29 publications

A Retrospective Study on the Time in Range of Blood Glucose and Type 2 Diabetic Peripheral Neuropathy

A Retrospective Study on the Time in Range of Blood Glucose and Type 2 Diabetic Peripheral Neuropathy

Elevated Homocysteine Levels and Vitamin Deficiencies as Potential Risk Markers for Coronary Artery Disease in Apparently Healthy Adults

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