Preferential development by mice of delayed hypersensitivity to purified basic proteins

Crowle, Alfred J.; Hu, Cai; A, Patrucco

doi:10.1016/0021-8707(68)90087-7

Cited by 49 publications

(36 citation statements)

References 20 publications

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“…Furthermore, it has been recently demonstrated that carboxymethylated lysozyme, although producing no detectable antibodies against lysozyme, can induce both delayed-type hypersensitivity and antibody tolerance to lysozyme (E. Benjamini, personal communication). On the other hand, methylated serum albumins induced delayed hypersensitivity which was essentially conjugate specific (19).…”

Section: Discussionmentioning

confidence: 95%

Immune Response to Chemically Modified Flagellin

Parish

1971

The Journal of Experimental Medicine

172

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In the preceding paper (1) some chemical, antigenic, and biological properties of a series of acetoacetylated derivatives of Salmonella adelaide flagellin were described. Several chemical and antigenic tests revealed that as flagellin was acetoacetylated to increasing extents there was a steady decline in the affinity of the molecule for anti-flagellin antibodies. This loss in antigenic activity appeared to be accompanied on the one hand by a reduced capacity to initiate antibody formation but on the other hand b y an enhanced ability to induce antibody tolerance. In this paper the antibody tolerance induced by these acetoacetylated flagellins is studied in more detail. Furthermore, the ability of these acetoacetyl derivatives to induce delayed-type hypersensitivity is reported. F r o m these studies it was found that suppression of antibody formation in adult rats was accompanied by enhanced cell-mediated immunity. In fact, it appears that in adult animals antibody formation and cell-mediated immunity m a y well be opposing immunological processes. By contrast, tolerance induced in neonatal rats by acetoacetyl flagellin existed at the level of both humoral and cell-mediated immunity. Some preliminary aspects of this work have been reported elsewhere. 1 Materials and MethodsAnimals.--Randomly bred Wistar rats of either sex were used. Animals were either obtained directly from the Walter and Eliza Hall Institute of Medical Research, Parkville, Australia, or bred in Canberra from Wistar breeders supplied by the Walter and Eliza Hall Institute. Both adult (6-10 wk of age) and neonatal rats were used.Antigens.--Flagellin and polymerized flagellin from S. adelaide (strain SW 1338; H antigen--fg) and flagellin from S. typhimurium (strain SL 871; H antigen--l, 2) were prepared as described previously (2). A cyanogen bromide (CNBr) digest of S. adelaide flagellin was prepared and fractionated into fragment A and a mixture of fragments B, C, and D as de-1 Parish, C. R. 1971. Suppression of antibody formation and concomitant enhancement of cell-mediated immunity by acetoacetylated derivatives of Salmonella flage]lin.

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Section: Discussionmentioning

confidence: 95%

Immune Response to Chemically Modified Flagellin

Parish

1971

The Journal of Experimental Medicine

172

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“…Crowle et al (23) claimed that methylation shifts the immune response towards delayed hypersensitivity and that the delayed hypersensitivity to native BSA is much weaker than that to mBSA. Katsura et al (15,24), however, showed clear development of delayed hypersensitivity to native BSA in mice, and our ear test data are in support of this (Table I).…”

Section: Methodsmentioning

confidence: 99%

Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice.

Berg¹,

Putte²,

Zwarts³

et al. 1984

J. Clin. Invest.

117

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“…Delayed hypersensitivity response to methylated BSA in mice: The procedure of Crowle et al was employed (22). Male C57BL/6 mice weighing 17 23 g were used in each group of 8 animals.…”

Section: Type IV Allergic Reactionmentioning

confidence: 99%

Comparative Studies on the Inhibitory Effects of Calcium Antagonists on Cytosolic Ca2+ Levels Increased by High-Potassium or Glutamate in Cultured Rat Cerebellar Granule Cells

Zhang¹,

Watanabe²,

Ohnishi³

et al. 1993

Japanese Journal of Pharmacology

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ABSTRACT-Theanti-allergic and anti-inflammatory activities of DS-4574, which possesses leukotriene antagonism and inhibits the release of immunologically stimulated mediators such as histamine and leukotrienes, were evaluated in several animal models. DS-4574 had dose-dependent inhibitory effects on IgE-mediated passive cutaneous anaphylaxis and the passive Arthus reaction in rats and the phase I response of Forssman antibody-induced bronchoconstriction.In contrast, this compound had no effect on the phase II response of Forssman antibody-induced bronchoconstriction in guinea pigs, the reverse cutaneous anaphylaxis in rats, complement-dependent hemolysis of sheep erythrocytes and the delayed-type hypersensitivity induced by methylated bovine serum albumin in mice. The results obtained in a double sen sitization with two IgE antibodies suggested that DS-4574, as well as disodium cromoglycate, did not impair antigen-antibody combination but prevents the release of chemical mediators such as histamine. DS-4574 also had a weak inhibitory activity on carrageenin paw edema in rats, arachidonic acid ear edema in mice and adjuvant arthritis in rats. In addition, this compound inhibited increased vascular permeability in rat skin induced by leukotriene D4 and platelet activating factor-induced pleurisy in rats in a dose-dependent manner. These results indicate that DS-4574 inhibited type III allergic reactions in addition to type I allergic reactions and some inflammatory reactions. Therefore, DS-4574 could be useful in the treatment of allergic diseases such as asthma.

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Preferential development by mice of delayed hypersensitivity to purified basic proteins

Cited by 49 publications

References 20 publications

Immune Response to Chemically Modified Flagellin

Immune Response to Chemically Modified Flagellin

Electrical charge of the antigen determines intraarticular antigen handling and chronicity of arthritis in mice.

Comparative Studies on the Inhibitory Effects of Calcium Antagonists on Cytosolic Ca2+ Levels Increased by High-Potassium or Glutamate in Cultured Rat Cerebellar Granule Cells

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