Preferential recognition of epitopes on AGE–IgG by the autoantibodies in rheumatoid arthritis patients

Ahmad, Saman; Habib, Safia; Moinuddin, Mohammed; Ali, Asif

doi:10.1016/j.humimm.2012.10.008

Cited by 14 publications

(7 citation statements)

References 27 publications

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“…Compared to healthy subjects, both diabetic and nondiabetic patients with coronary artery disease had a higher concentration of circulating immune complexes containing the AGE moiety as antigen, whereas only diabetics had higher anti-AGE antibodies [223]. Autoantibodies to IgG-AGE were detected in patients with rheumatoid arthritis, suggesting that glycation of IgG results in the generation of new immunogenic epitopes, potentially inducing circulating autoantibodies [224]. Therefore, AGEs could be one of the links between metabolic syndrome and immune activation.…”

Section: Markers Based On Ros-induced Modificationsmentioning

confidence: 99%

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

Marrocco

Altieri

Peluso

2017

Oxidative Medicine and Cellular Longevity

648

500

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Oxidative stress is the result of the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidants. Biomarkers of oxidative stress are relevant in the evaluation of the disease status and of the health-enhancing effects of antioxidants. We aim to discuss the major methodological bias of methods used for the evaluation of oxidative stress in humans. There is a lack of consensus concerning the validation, standardization, and reproducibility of methods for the measurement of the following: (1) ROS in leukocytes and platelets by flow cytometry, (2) markers based on ROS-induced modifications of lipids, DNA, and proteins, (3) enzymatic players of redox status, and (4) total antioxidant capacity of human body fluids. It has been suggested that the bias of each method could be overcome by using indexes of oxidative stress that include more than one marker. However, the choice of the markers considered in the global index should be dictated by the aim of the study and its design, as well as by the clinical relevance in the selected subjects. In conclusion, the clinical significance of biomarkers of oxidative stress in humans must come from a critical analysis of the markers that should give an overall index of redox status in particular conditions.

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Section: Markers Based On Ros-induced Modificationsmentioning

confidence: 99%

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

Marrocco

Altieri

Peluso

2017

Oxidative Medicine and Cellular Longevity

648

500

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“…This finding was related to downregulation of CAT, SOD, and GPx and decreased GSH levels, along with TNF- α -associated ER stress. Immune imbalance included excess AGE-IgG and chemokine (MCP-1/CCL2, RANTES/CCL5)-associated ROS [264–268]. Mitochondrial damage was reported as mtDNA mutations that were positively correlated with macroscopic synovitis [269].…”

Section: Autoimmune Diseasesmentioning

confidence: 99%

Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

Pagano

Talamanca

Castello

et al. 2014

Oxidative Medicine and Cellular Longevity

118

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Beyond the disorders recognized as mitochondrial diseases, abnormalities in function and/or ultrastructure of mitochondria have been reported in several unrelated pathologies. These encompass ageing, malformations, and a number of genetic or acquired diseases, as diabetes and cardiologic, haematologic, organ-specific (e.g., eye or liver), neurologic and psychiatric, autoimmune, and dermatologic disorders. The mechanistic grounds for mitochondrial dysfunction (MDF) along with the occurrence of oxidative stress (OS) have been investigated within the pathogenesis of individual disorders or in groups of interrelated disorders. We attempt to review broad-ranging pathologies that involve mitochondrial-specific deficiencies or rely on cytosol-derived prooxidant states or on autoimmune-induced mitochondrial damage. The established knowledge in these subjects warrants studies aimed at elucidating several open questions that are highlighted in the present review. The relevance of OS and MDF in different pathologies may establish the grounds for chemoprevention trials aimed at compensating OS/MDF by means of antioxidants and mitochondrial nutrients.

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“…Finally, autoantibodies targeting AGE-modified IgG are also present in serum of RA patients [154, 201]. Autoantibodies against AGE-IgG might be helpful in monitoring progress in the RA disease continuum and in combination with other clinical features of the RA might be a useful diagnostic tool [201].…”

Section: Antioxidized Protein Antibodies In Ramentioning

confidence: 99%

“…Autoantibodies against AGE-IgG might be helpful in monitoring progress in the RA disease continuum and in combination with other clinical features of the RA might be a useful diagnostic tool [201]. …”

Section: Antioxidized Protein Antibodies In Ramentioning

confidence: 99%

Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis

Burska

Hunt

Boissinot

et al. 2014

Mediators of Inflammation

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Autoantibodies have been associated with human pathologies for a long time, particularly with autoimmune diseases (AIDs). Rheumatoid factor (RF) is known since the late 1930s to be associated with rheumatoid arthritis (RA). The discovery of anticitrullinated protein antibodies in the last century has changed this and other posttranslational modifications (PTM) relevant to RA have since been described. Such PTM introduce neoepitopes in proteins that can generate novel autoantibody specificities. The recent recognition of these novel specificities in RA provides a unique opportunity to understand human B-cell development in vivo. In this paper, we will review the three of the main classes of PTMs already associated with RA: citrullination, carbamylation, and oxidation. With the advancement of research methodologies it should be expected that other autoantibodies against PTM proteins could be discovered in patients with autoimmune diseases. Many of such autoantibodies may provide significant biomarker potential.

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Preferential recognition of epitopes on AGE–IgG by the autoantibodies in rheumatoid arthritis patients

Cited by 14 publications

References 27 publications

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans

Oxidative Stress and Mitochondrial Dysfunction across Broad-Ranging Pathologies: Toward Mitochondria-Targeted Clinical Strategies

Autoantibodies to Posttranslational Modifications in Rheumatoid Arthritis

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