Preferential sputtering in phosphate glass systems for the processing of bioactive coatings

Stuart, Bryan W.; Gimeno-Fabra, Miquel; Segal, Joel; Ahmed, Ifty; Grant, David M.

doi:10.1016/j.tsf.2015.05.072

Cited by 25 publications

(16 citation statements)

References 50 publications

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“…Following this peripheral attempt, there can be identified in the main scientific data bases (e.g., Web of Science ® , Scopus ® , Pubmed ® ) significant research efforts devoted by the groups led by Jansen and van den Beucken [359,361,370,371,372], on SBG—hydroxyapatite mixed layers, and Stan and Ferreira [151,304,307,308,309,310,311,312,313,362,363,373,374], (on pure SBG thin films, with only isolated trials published by Slav et al [360] and Saino et al [364]. Recently, Stuart et al [375,376,377,378,379] debuted a series of studies on the preparation by RF-MS of resorbable phosphate bioglass (PBG) thin films that are capable of releasing various therapeutic (e.g., antimicrobial) ions in a fast, but controllable manner.…”

Section: Bioactive Glasses and Glass-ceramicsmentioning

confidence: 99%

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

et al. 2018

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The discovery of bioactive glasses (BGs) in the late 1960s by Larry Hench et al. was driven by the need for implant materials with an ability to bond to living tissues, which were intended to replace inert metal and plastic implants that were not well tolerated by the body. Among a number of tested compositions, the one that later became designated by the well-known trademark of 45S5 Bioglass® excelled in its ability to bond to bone and soft tissues. Bonding to living tissues was mediated through the formation of an interfacial bone-like hydroxyapatite layer when the bioglass was put in contact with biological fluids in vivo. This feature represented a remarkable milestone, and has inspired many other investigations aiming at further exploring the in vitro and in vivo performances of this and other related BG compositions. This paradigmatic example of a target-oriented research is certainly one of the most valuable contributions that one can learn from Larry Hench. Such a goal-oriented approach needs to be continuously stimulated, aiming at finding out better performing materials to overcome the limitations of the existing ones, including the 45S5 Bioglass®. Its well-known that its main limitations include: (i) the high pH environment that is created by its high sodium content could turn it cytotoxic; (ii) and the poor sintering ability makes the fabrication of porous three-dimensional (3D) scaffolds difficult. All of these relevant features strongly depend on a number of interrelated factors that need to be well compromised. The selected chemical composition strongly determines the glass structure, the biocompatibility, the degradation rate, and the ease of processing (scaffolds fabrication and sintering). This manuscript presents a first general appraisal of the scientific output in the interrelated areas of bioactive glasses and glass-ceramics, scaffolds, implant coatings, and tissue engineering. Then, it gives an overview of the critical issues that need to be considered when developing bioactive glasses for healthcare applications. The aim is to provide knowledge-based tools towards guiding young researchers in the design of new bioactive glass compositions, taking into account the desired functional properties.

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Section: Bioactive Glasses and Glass-ceramicsmentioning

confidence: 99%

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

et al. 2018

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“…FTIR spectra (Figure 4) indicated an intensity enhancement of ), determined by the Q Si 4 silicate units. SEM analysis of BG-coating surfaces ( Figure 5) revealed morphologies that were typical of amorphous structures deposited by radio-frequency magnetron sputtering, [51][52][53] characterization of in vitro-tested BG films…”

Section: Characterization Of Starting Bg Powder and As-sputtered Bg Cmentioning

confidence: 99%

Bioglass implant-coating interactions in synthetic physiological fluids with varying degrees of biomimicry

Popa¹,

Stan²,

Husanu³

et al. 2017

IJN

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Synthetic physiological fluids are currently used as a first in vitro bioactivity assessment for bone grafts. Our understanding about the interactions taking place at the fluid–implant interface has evolved remarkably during the last decade, and does not comply with the traditional International Organization for Standardization/final draft International Standard 23317 protocol in purely inorganic simulated body fluid. The advances in our knowledge point to the need of a true paradigm shift toward testing physiological fluids with enhanced biomimicry and a better understanding of the materials’ structure-dissolution behavior. This will contribute to “upgrade” our vision of entire cascades of events taking place at the implant surfaces upon immersion in the testing media or after implantation. Starting from an osteoinductive bioglass composition with the ability to alleviate the oxidative stress, thin bioglass films with different degrees of polymerization were deposited onto titanium substrates. Their biomineralization activity in simulated body fluid and in a series of new inorganic–organic media with increasing biomimicry that more closely simulated the human intercellular environment was compared. A comprehensive range of advanced characterization tools (scanning electron microscopy; grazing-incidence X-ray diffraction; Fourier-transform infrared, micro-Raman, energy-dispersive, X-ray photoelectron, and surface-enhanced laser desorption/ionization time-of-flight mass spectroscopies; and cytocompatibility assays using mesenchymal stem cells) were used. The information gathered is very useful to biologists, biophysicists, clinicians, and material scientists with special interest in teaching and research. By combining all the analyses, we propose herein a step forward toward establishing an improved unified protocol for testing the bioactivity of implant materials.

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“…Other techniques such as ion beam [44] and magnetron sputtering [45][46][47] have been also explored for depositing BG coatings on flat Ti substrates. Mistry et al [48] compared the performance of air microplasma sprayed HA and enamelled S53P4 BG coatings in clinical trials.…”

Section: Introductionmentioning

confidence: 99%

Superior biofunctionality of dental implant fixtures uniformly coated with durable bioglass films by magnetron sputtering

Popa¹,

Stan

Enculescu

et al. 2015

Journal of the Mechanical Behavior of Biomedical Materials

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Preferential sputtering in phosphate glass systems for the processing of bioactive coatings

Cited by 25 publications

References 50 publications

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

Bioactive Glasses and Glass-Ceramics for Healthcare Applications in Bone Regeneration and Tissue Engineering

Bioglass implant-coating interactions in synthetic physiological fluids with varying degrees of biomimicry

Superior biofunctionality of dental implant fixtures uniformly coated with durable bioglass films by magnetron sputtering

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