Prefrontal-Enriched SLIT1 Expression in Old World Monkey Cortex Established during the Postnatal Development

Sasaki, Takuma; Komatsu, Yusuke; Watakabe, Akiya; Sawada, Kaoru; Yamamori, Tetsuo

doi:10.1093/cercor/bhp319

Cited by 13 publications

(15 citation statements)

References 92 publications

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“…6, A and B); it was also partially down-regulated in the adjacent mAC of zebra finches. Likewise, macaques have recently been shown to have lower SLIT1 in primary motor cortex (69), which we also found in marmosets (fig. S13).…”

Section: In Situ Patterns Of Commonly Specialized Avian Ra and Human supporting

confidence: 83%

Convergent transcriptional specializations in the brains of humans and song-learning birds

Pfenning

Hara

Whitney

et al. 2014

Science

420

469

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Song-learning birds and humans share independently evolved similarities in brain pathways for vocal learning that are essential for song and speech and are not found in most other species. Comparisons of brain transcriptomes of song-learning birds and humans relative to vocal nonlearners identified convergent gene expression specializations in specific song and speech brain regions of avian vocal learners and humans. The strongest shared profiles relate bird motor and striatal song-learning nuclei, respectively, with human laryngeal motor cortex and parts of the striatum that control speech production and learning. Most of the associated genes function in motor control and brain connectivity. Thus, convergent behavior and neural connectivity for a complex trait are associated with convergent specialized expression of multiple genes.

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Section: In Situ Patterns Of Commonly Specialized Avian Ra and Human supporting

confidence: 83%

Convergent transcriptional specializations in the brains of humans and song-learning birds

Pfenning

Hara

Whitney

et al. 2014

Science

420

469

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“…In previous studies, the area-specific gene expression profiles in the primate neocortex were examined ( Yamamori and Rockland, 2006 ; Yamamori, 2011 ; Bernard et al, 2012 ). Genes selectively expressed in association areas ( Komatsu et al, 2005 ; Takaji et al, 2009 ; Sasaki et al, 2010 ) and the primary visual cortex ( Takahata et al, 2006 ; Watakabe et al, 2009 ) were reported. Importantly, area-selective expressions of these genes are not observed in rodents ( Yamamori, 2011 ).…”

Section: Discussionmentioning

confidence: 99%

In VivoTwo-Photon Imaging of Dendritic Spines in Marmoset Neocortex

Sadakane

Watakabe

Ohtsuka

et al. 2015

eneuro

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Two-photon microscopy in combination with a technique involving the artificial expression of fluorescent protein has enabled the direct observation of dendritic spines in living brains. However, the application of this method to primate brains has been hindered by the lack of appropriate labeling techniques for visualizing dendritic spines. Here, we developed an adeno-associated virus vector-based fluorescent protein expression system for visualizing dendritic spines in vivo in the marmoset neocortex. For the clear visualization of each spine, the expression of reporter fluorescent protein should be both sparse and strong. To fulfill these requirements, we amplified fluorescent signals using the tetracycline transactivator (tTA)–tetracycline-responsive element system and by titrating down the amount of Thy1S promoter-driven tTA for sparse expression. By this method, we were able to visualize dendritic spines in the marmoset cortex by two-photon microscopy in vivo and analyze the turnover of spines in the prefrontal cortex. Our results demonstrated that short spines in the marmoset cortex tend to change more frequently than long spines. The comparison of in vivo samples with fixed samples showed that we did not detect all existing spines by our method. Although we found glial cell proliferation, the damage of tissues caused by window construction was relatively small, judging from the comparison of spine length between samples with or without window construction. Our new labeling technique for two-photon imaging to visualize in vivo dendritic spines of the marmoset neocortex can be applicable to examining circuit reorganization and synaptic plasticity in primates.

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“…One possibility is that Robo determines srGAP localization at the plasma membrane and therefore regulates the site of spine formation. Furthermore, it will be interesting to clarify the roles of Slit-Robo and srGAP signaling in the diversification of spine formation among different functional regions of the neocortex ( Benavides-Piccione et al, 2002 ; Konur et al, 2003 ; Sasaki et al, 2010 ).…”

Section: Srgap and Robo Signaling In Spine Formationmentioning

confidence: 99%

Beyond Axon Guidance: Roles of Slit-Robo Signaling in Neocortical Formation

Gonda

Namba

Hanashima

2020

Front. Cell Dev. Biol.

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The formation of the neocortex relies on intracellular and extracellular signaling molecules that are involved in the sequential steps of corticogenesis, ranging from the proliferation and differentiation of neural progenitor cells to the migration and dendrite formation of neocortical neurons. Abnormalities in these steps lead to disruption of the cortical structure and circuit, and underly various neurodevelopmental diseases, including dyslexia and autism spectrum disorder (ASD). In this review, we focus on the axon guidance signaling Slit-Robo, and address the multifaceted roles of Slit-Robo signaling in neocortical development. Recent studies have clarified the roles of Slit-Robo signaling not only in axon guidance but also in progenitor cell proliferation and migration, and the maturation of neocortical neurons. We further discuss the etiology of neurodevelopmental diseases, which are caused by defects in Slit-Robo signaling during neocortical formation.

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Prefrontal-Enriched SLIT1 Expression in Old World Monkey Cortex Established during the Postnatal Development

Cited by 13 publications

References 92 publications

Convergent transcriptional specializations in the brains of humans and song-learning birds

Convergent transcriptional specializations in the brains of humans and song-learning birds

In VivoTwo-Photon Imaging of Dendritic Spines in Marmoset Neocortex

Beyond Axon Guidance: Roles of Slit-Robo Signaling in Neocortical Formation

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