Pregnancy-induced changes in lower extremity superficial veins: An ultrasound scan study

Boivin, Pierre; Cornu‐Thénard, A.; Charpak, Y

doi:10.1067/mva.2000.107991

Cited by 32 publications

(29 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Chronic venous disease (CVD) refers to various anomalies commonly affecting the lower extremities, in which venous return is abnormal, and varicose veins are the most important clinical manifestation [1]. Pregnancy is associated with an increased risk of developing chronic venous disorder [2,3]. Risk factors associated with venous disorder during pregnancy include genetic factors and family history, occupation, and the number of pregnancies or the interval between pregnancies [4].…”

Section: Introductionmentioning

confidence: 99%

Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy

Ortega

Sáez

Fraile-Martínez

et al. 2020

IJMS

View full text Add to dashboard Cite

Pregnancy is a period in a woman’s life associated with an increased risk of developing lower extremity chronic venous disease (CVD). Pregnancy-associated CVD is associated with changes in placental villi. We investigated angiogenesis and lymphangiogenesis in the placental villi of women with CVD during pregnancy compared with healthy controls with no history of CVD (HC). An observational, analytical, and prospective cohort study was conducted on 114 women in their third trimester of pregnancy (32 weeks). Sixty-two participants were clinically diagnosed with CVD. In parallel, 52 controls with no history of CVD (HC) were studied. Gene and protein expression of CD31, podoplanin (D2-40), Flt-1, and placental growth factor (PIGF) was analysed by real-time polymerase chain reaction (RT-qPCR) and immunohistochemistry. CD31 and D2-40 gene expression was significantly greater in the placental villi of women with CVD, as were the numbers of vessels positive for CD31 and D2-40. Significantly higher gene and protein expression of Flt-1 and PIGF was observed in the placental villi of women with CVD. Histological analysis showed more placental villi with periodic acid of Schiff (PAS)-positive material in women with CVD. Our results show a connection between pregnancy-associated CVD and leading to higher proangiogenic and lymphangiogenic activity in placental villi.

show abstract

Section: Introductionmentioning

confidence: 99%

Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy

Ortega

Sáez

Fraile-Martínez

et al. 2020

IJMS

View full text Add to dashboard Cite

show abstract

“…17 Also, Sparey et al found that normal veins, in spite of changes in venous diameter during pregnancy comparable with that seen in those with pre-existing venous disease, return to normal after delivery, but some VVs deteriorate during pregnancy, and this may be progressive with successive pregnancies. 18 Previously, Cornu-Thenard et al had already observed a correlation between the total number of pregnancies and the size of VVs.…”

Section: Risk Factors and Concurrent Diseasesmentioning

confidence: 99%

“…31 Some authors have defined as non-saphenous reflux those VVs that are not part of GSV or SSV systems. 17,32 Therefore, they include reflux from perineal and PV systems. From our point of view, they should differentiate.…”

Section: Reflux Pattern According To the Venous Reflux Pointmentioning

confidence: 99%

Reflux patterns and risk factors of primary varicose veins’ clinical severity

et al. 2013

View full text Add to dashboard Cite

Objectives: Primarily, to determine the association between the clinical severity of primary varicose veins and different reflux patterns in an anatomic and haemodynamic clinical study using duplex ultrasonography (DU). Secondly, to analyse the association of clinical severity with other aspects, such as risk factors for chronic venous insufficiency (CVI) and other concurrent diseases. Method: A total of 2036 limbs were evaluated using DU. Clinical status was characterized by the CEAP (clinical, aetiological, anatomical and pathological elements) classification. The degree of clinical severity was grouped into two categories, mild to moderate CVI (C 1 -C 3 ) and severe CVI, characterized by the presence of skin changes (C 4 -C 6 ). We analysed the association of the different reflux patterns with CEAP status. Results: Saphenofemoral junction (SFJ) reflux of the great saphenous vein (GSV) was associated with the most severe form of the disease (odds ratio [OR] ¼ 2.96; confidence interval [CI] 95%: 2.2-3.8), whereas competent SFJ of the GSV with reflux from proximal veins (OR ¼ 2; CI 95%: 1.4 -2.7) and the pure non-saphenous reflux (OR ¼ 4.1; CI 95%: 1.8-9.0) were associated with mild to moderate CVI. Obesity increased the frequency of severe CVI 2.7 times (OR ¼ 2.7; CI 95%: 1.6-4.6); being a woman also increased the frequency of more severe disease 1.3 times (OR ¼ 1.3; CI 95%: 1.0-1.7). Conclusion: Anatomical and haemodynamic studies by DU are postulated as a useful diagnostic tool that allow, by identifying the pattern of venous reflux of varicose pathology, characterization of the probable association to CVI clinical severity.

show abstract

“…This may be attributed to hormonal variation from the onset of menses until menopause and during pregnancy. [15][16][17][18][19][20] The prevalence of reflux in SN and TN among all the limbs studied was 1% (9/835) and of the limbs with nonsaphenous vein reflux 10.7% (9/84).…”

Section: Discussionmentioning

confidence: 98%

Veins along the course of the sciatic nerve

Labropoulos

Tassiopoulos

Gasparis

et al. 2009

Journal of Vascular Surgery

View full text Add to dashboard Cite

show abstract

Pregnancy-induced changes in lower extremity superficial veins: An ultrasound scan study

Abstract: The diameters of competent and incompetent superficial veins increased during pregnancy and decreased during the postpartum period to return to their baseline values.

Cited by 32 publications

References 17 publications

Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy

Increased Angiogenesis and Lymphangiogenesis in the Placental Villi of Women with Chronic Venous Disease during Pregnancy

Reflux patterns and risk factors of primary varicose veins’ clinical severity

Veins along the course of the sciatic nerve

Contact Info

Product

Resources

About