Pregnancy obtained by the transfer of frozen-thawed embryos originating from a rescued empty follicle syndrome cycle

Empty follicle syndrome: the reality of a controversial syndrome, a systematic review

“…The mechanisms responsible for EFS remain obscure, though many hypotheses have been put forward ranging from human error (6,(9)(10)(11) to pharmacologic problems (8,11,12).…”

Recurrent genuine empty follicle syndrome

“…The low biological activity of hCG may be due to an inadequate dosage or timing,[313] individual variation in the threshold for the follicular response to urinary hCG,[14] or rapid clearance of urinary hCG. [4] A rescue hCG using a second dose or different batch of urinary hCG or recombinant hCG can be used if the βhCG concentration is <100 mIU/ml[9] or <40 mIU/ml[12] and oocyte retrieval is done 24-36 h later.…”

Rescue human chorionic gonadotropin for false empty follicle syndrome: optimism for successful pregnancy outcome

“…A rescue course of hCG with repeat oocyte retrieval of intact follicles 35-37 hours later has been a proposed method of addressing this failure (1). Although some case reports describe successful pregnancies after using this method, a recent larger series of data have suggested a limited prognosis (1)(2)(3)(4)(5)(6).…”