Pregnancy outcomes after controlled ovarian hyperstimulation in women with endometriosis-associated infertility: GnRH-agonist versus GnRH-antagonist

Kolańska, Kamila; Cohen, Jonathan; Bendifallah, Sofiane; Selleret, Lise; Antoine, Jean-Marie; Chabbert-Buffet, Nathalie; Daraı̈, Émile; d’Argent, Emmanuelle Mathieu

doi:10.1016/j.jogoh.2017.09.007

Cited by 33 publications

(55 citation statements)

References 26 publications

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“…Patients were stimulated either with a long gonadotropin-releasing hormone (GnRH) agonist or an antagonist protocol. At our center, we offer the long agonist protocol first line for patients with endometriosis, based on studies showing better pregnancy rates [20]. For the long agonist protocol, pituitary desensitization was achieved with daily triptorelin 0.1 mg, started on the twenty first day of the previous cycle.…”

Section: Controlled Ovarian Stimulationmentioning

confidence: 99%

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

Boucret

Bouet

Riou

et al. 2020

JCM

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Endometriosis and infertility are closely linked, but the underlying mechanisms are still poorly understood. This study aimed to evaluate the impact of endometriosis on in vitro fertilization (IVF) parameters, especially on embryo quality and IVF outcomes. A total of 1124 cycles with intracytoplasmic sperm injection were retrospectively evaluated, including 155 cycles with endometriosis and 969 cycles without endometriosis. Women with endometriosis had significantly lower ovarian reserve markers (AMH and AFC), regardless of previous ovarian surgery. Despite receiving significantly higher doses of exogenous gonadotropins, they had significantly fewer oocytes, mature oocytes, embryos, and top-quality embryos than women in the control group. Multivariate analysis did not reveal any association between endometriosis and the proportion of top-quality embryo (OR = 0.87; 95% CI [0.66–1.12]; p = 0.3). The implantation rate and the live birth rate per cycle were comparable between the two groups (p = 0.05), but the cumulative live births rate was significantly lower in in the endometriosis group (32.1% versus 50.7%, p = 0.001), as a consequence of the lower number of frozen embryos. In conclusion, endometriosis lowers the cumulative live birth rates by decreasing the number of embryos available to transfer, but not their quality.

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Section: Controlled Ovarian Stimulationmentioning

confidence: 99%

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

Boucret

Bouet

Riou

et al. 2020

JCM

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show abstract

“…Namely, the study of Dechanet presented that the surgery before IVF increasing the pregnancy rate in women with endometriomas [18]. Gonadotropin-releasing hormone (GnRH) agonists have also been reported to increase pregnancy rate compared to GnRH antagonists [19]. The recent study showed that surgery for big endometrioma could be required before IVF to facilitate access to follicles during oocyte retrieval or to improve the ovarian response to controlled ovarian stimulation.…”

Section: Discussionmentioning

confidence: 99%

The Impact of Laparoscopic Treated Endometrioma on the Live Birth Rate in IVF/ICSI Cycles Compared with Unexplained Infertility: A Prospective Randomized Study

Stojkovska¹,

Dimitrov²,

Stojkovski³

et al. 2020

Open Access Maced J Med Sci

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BACKGROUND: It is estimated that 30–70% of patients who undergo treatment for infertility are afflicted with endometriosis. AIM: The objectives of this study are to evaluate the impact of laparoscopic treated endometrioma compared to unexplained subfertility on the live birth rate in women undergoing in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI). METHODS: This randomized prospective study included 120 women who contacted the department of IVF in the period from 2010 to 2015. Women were divided into two groups according to the findings obtained by laparoscopy. The treated endometrioma group (n = 60) with unilateral ovarian endometriomas and the non-endometriosis group (n = 60) with unexplained infertility undergoing the first cycle of IVF-embryo transfer (IVF-ET) were included in the study. In all participants, ICSI was used and all had fresh embryo transfer per cycle. The primary outcome was to live birth. RESULTS: Our results demonstrated that clinical pregnancy rates (p = 0.54) and live birth rate (p = 0.63) are similar. The preservation of a good ovarian response to stimulation by gonadotropins after laparoscopic ovarian cystectomy was presented. Laparoscopic cystectomy is followed by good IVF/ICSI outcome into the level expected in women with unexplained subfertility. CONCLUSION: Therefore, operative treatment is justified by not altering the live birth rate. Additional study is needed to be considered cystectomy before IVF as an effective approach for managing endometriosis-associated infertility.

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“…Long protocol with agonists was most frequently used protocol in the cycles with achieved pregnancy. Studies show that GnRH-agonist protocol may result in higher pregnancy as well as live-birth rates after fresh ET in women with endometriosis [29]. It is possible that protocols with antagonists might negatively impact endometrial receptivity in these situations [29].…”

Section: Discussionmentioning

confidence: 99%

“…Studies show that GnRH-agonist protocol may result in higher pregnancy as well as live-birth rates after fresh ET in women with endometriosis [29]. It is possible that protocols with antagonists might negatively impact endometrial receptivity in these situations [29]. The role of LH supplementation for improving outcomes in patients undergoing COH for IVF cycles is unclear, although it has been suggested that patients with poor ovarian reserve may benefit from LH supplementation [30].…”

Section: Discussionmentioning

confidence: 99%

Predictors of IVF/ICSI success following treatment of endometriosis as the cause of primary infertility

et al. 2018

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Pregnancy outcomes after controlled ovarian hyperstimulation in women with endometriosis-associated infertility: GnRH-agonist versus GnRH-antagonist

Cited by 33 publications

References 26 publications

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

Endometriosis Lowers the Cumulative Live Birth Rates in IVF by Decreasing the Number of Embryos but Not Their Quality

The Impact of Laparoscopic Treated Endometrioma on the Live Birth Rate in IVF/ICSI Cycles Compared with Unexplained Infertility: A Prospective Randomized Study

Predictors of IVF/ICSI success following treatment of endometriosis as the cause of primary infertility

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