Pregnancy outcomes in papillary thyroid cancer survivors：A retrospective cohort study

Abstract

ObjectiveThe purpose of this study was to evaluate the pregnancy outcomes among papillary thyroid cancer survivors.Methods65 cases singleton gravidas of papillary thyroid cancer survivors treated in the Department of Obstetrics, Peking University People's Hospital between January 2011 and January 2020 were selected retrospectively as the study group, and 130 cases of singleton pregnancy during the same time were randomly selected as the control group. The differences in general conditions, maternal and fetal complications between the two groups were analyzed. Risk factors of maternal complications and fetal malformation in patients with papillary thyroid cancer survivors were analyzed. Data was analyzed witht-test,χ2test and logistic regression for statistical differences.ResultsTotally 65 cases of papillary thyroid cancer with 70 pregnancies were analyzed, which including 65 cases achieved live birth, 5 cases underwent induced labor because of fetal malformation. The study group showed higher incidence in gestational diabetes(20% vs 10%), cesarean section(39.1% vs 24.6%), postpartum hemorrhage(350 ​± ​193 ​ml vs 290 ​± ​181 ​ml) and fetal malformation(5.7% vs 1.5%), and lower live birth rate(91.4% vs 99.2%) (P ​< ​0.05). Multivariate analysis by logistic regression found that the patient's age, thyroid function, operation mode and postoperative I-131 treatment were not the risk factors which may affect the pregnancy outcomes or fetal malformation.ConclusionElevated maternal and fetal complications were observed among pregnancies in papillary thyroid cancer survivors. Management of these survivors may require a careful gestation monitoring, and further investigation is needed.