Pregnancy outcomes in patients after radical trachelectomy

Bernardini, Marcus Q.; Barrett, Jon; Seaward, Gareth; Covens, Allan

doi:10.1067/s0002-9378(03)00776-2

Cited by 179 publications

(99 citation statements)

References 17 publications

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“…All neonates weighed over 2900 g. The prophylactic cerclage of the residual uterine body was recommended by other authors as well [26] and proved to be an efficient way of reducing the risk of miscarriage, ascending infections, and premature rupture of membranes. The number of obtained pregnancies was consistent with our patients' desire for postoperative fertility.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Radical Vaginal Trachelectomy with Laparoscopic Pelvic Lymphadenectomy for Fertility Preservation in Young Women with Early-Stage Cervical Cancer

Brătilă

Coroleucă³

2015

Indian J Surg

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The primary objective of this study was to describe our experience with the conservative treatment of early-stage cervical cancer (stages IA1, IA2, and IB1) with radical vaginal trachelectomy (RVT) and laparoscopic pelvic lymphadenectomy. This retrospective observational case series included 36 patients with early cervical cancer. Radical trachelectomy and laparoscopic pelvic lymphadenectomy were performed as described by D. Dargent in 32 of these cases. Oncologic, reproductive, and obstetric outcomes were observed subsequently over a median period of 42 (24-96) weeks. A total of 32 RVTs were preformed with a mean operating time of 117±22.8 (77-167) minutes and an average blood loss of 486 mL (150-800 mL). All obtained resection margins were negative for cancer. Lymphovascular space invasion was noted in 11 (30.55 %) of the cases. No recurrences occurred during the study period. Seven (17.8 %) patients were able to become pregnant postoperatively, five of whom delivered healthy infants near term. Radical vaginal trachelectomy with laparoscopic pelvic lymphadenectomy appears to be a safe therapeutic option for fertility preservation in young women with early cervical cancer.

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Section: Discussionmentioning

confidence: 99%

“…In this case series, two (6.25 %) patients had miscarriages in the first trimester of pregnancy and required surgical evacuation of the uterine contents by dilation and curettage. This outcome ranks under the rates of miscarriage after RVT described in the literature [21,26,27].…”

Section: Discussionmentioning

confidence: 99%

Radical Vaginal Trachelectomy with Laparoscopic Pelvic Lymphadenectomy for Fertility Preservation in Young Women with Early-Stage Cervical Cancer

Brătilă

Coroleucă³

2015

Indian J Surg

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“…The main reason for this may be postoperative changes in the cervical area (changes in the cervical mucous and cervical stenoses) [15].…”

Section: Discussionmentioning

confidence: 99%

Fertility-conserving treatment of early stage cervical cancer using trachelectomy and laparoscopic lymphadenectomy-a case report and a review of recent literature

et al. 2007

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Fertility-conserving surgical treatment of patients with early stage cervical cancer poses a particular challenge. In specialist centres, trachelectomy with laparoscopic lymphadenectomy could be established as a minimally invasive, fertilitypreserving alternative to radical hysterectomy for women of child-bearing age. This report describes the case of a 33-yearold patient who wished to conceive and was diagnosed with cervical cancer stage pT1a1 in 2004. The patient conceived 9 months after surgery and gave birth to a healthy baby girl at 38+0 weeks. Complications during pregnancy were gestational diabetes, premature contractions and pre-eclampsia at 37 weeks. The advantages and disadvantages of this method as well as the specific ante-natal monitoring required are discussed.

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“…Of the women who were planning to conceive, only those who had already had fertility problems or failed to conceive prior to trachelectomy had problems afterwards. Possible changes that might influence fertility which are caused by the surgery itself are: reduced cervical mucus; adhesions; reduced blood flow through the uterus, fallopian tubes and ovaries; or cervical stenosis (30)(31)(32)(33)(34)(35)(36). The reduction in fertility caused by the surgery itself seems minimal.…”

Section: Fertility and Pregnancymentioning

confidence: 99%

“…The greatest challenge post RVT is not to achieve pregnancy but to reduce the increased rate of preterm labor (29)(30)(31)(32)(33)(34).…”

Section: Fertility and Pregnancymentioning

confidence: 99%

Radical Vaginal Trachelectomy

Speiser¹,

Köhler²,

Schneider³

et al. 2013

Deutsches Ärzteblatt International

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Pregnancy outcomes in patients after radical trachelectomy

Cited by 179 publications

References 17 publications

Radical Vaginal Trachelectomy with Laparoscopic Pelvic Lymphadenectomy for Fertility Preservation in Young Women with Early-Stage Cervical Cancer

Radical Vaginal Trachelectomy with Laparoscopic Pelvic Lymphadenectomy for Fertility Preservation in Young Women with Early-Stage Cervical Cancer

Fertility-conserving treatment of early stage cervical cancer using trachelectomy and laparoscopic lymphadenectomy-a case report and a review of recent literature

Radical Vaginal Trachelectomy

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