Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection

Bartoov, B.; Berkovitz, Arie; Eltes, F.; Kogosovsky, Avraham; Yagoda, Arie; Lederman, Hanna; Artzi, Shira; Groß, Martin; Barak, Yona

doi:10.1016/j.fertnstert.2003.05.016

Cited by 348 publications

(269 citation statements)

References 19 publications

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“…Moreover, we could not find any deviations of early morphokinetics after fertilization with class I or class II/III spermatozoa. These observations confirm previous findings suggesting that the grade of sperm head vacuolization has no impact on the embryo outcome on day 3 [22,28,33,55]. Thus, the value of embryo selection prior to EGA remains questionable as the real developmental potency of the embryo cannot be properly estimated.…”

Section: Resultssupporting

confidence: 85%

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The impact of paternal factors on cleavage stage and blastocyst development analyzed by time-lapse imaging—a retrospective observational study

Neyer

Zintz

Stecher

et al. 2015

J Assist Reprod Genet

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Purpose Various time-lapse studies have postulated embryo selection criteria based on early morphokinetic markers. However, late paternal effects are mostly not visible before embryonic genome activation. The primary objective of this retrospective study was to investigate whether those early morphokinetic algorithms investigated by time-lapse imaging are reliable enough to allow for the accurate selection of those embryos that develop into blastocysts, while of course taking into account the correlation with the type of injected spermatozoa. Methods During a period of 18 months, a total of 461 MII oocytes from 43 couples with severe male factor infertility and previous Bexternal^IVF failures after cleavage-stage embryo transfer (ET) were fertilized by intracytoplasmic morphologically selected sperm injection (IMSI). Thereof, 373 embryos were monitored in a time-lapse incubator until ET on day 5. Blastocyst outcome in combination with three previously postulated MKc (cc2: t3-t2, 5-12 h; t3, 35-40 h; t5, 48-56 h) and the morphology of the selected sperm were analyzed. Results A significant increase in the rate of blastocysts (54.0 vs. 36.3 %; P<0.01) and top blastocysts (25.3 vs. 10.8 %; P<0.001) was observed in the group of those meeting all three morphokinetic criteria (MKc3). However, MKc3 were only met in 23.3 % of all embryos. Moreover, TBR was influenced by the type of injected spermatozoa. In both groups, TBR decreased dramatically (MKc3, 35.0 vs. 17.0 %; MKc<3, 14.2 vs. 8.4 %) when class II/III sperm instead of class I were injected. Conclusion Early morphokinetic parameters might give some predictive information but fail to serve as a feasible selective tool for the prediction of blastocyst development given the influence of the type of spermatozoa injected.

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Section: Resultssupporting

confidence: 85%

“…It has been reported that the negative impact of large nuclear vacuoles (LNV) is perceptible after the onset of the EGA, leading to reduced blastocyst formation [28][29][30][31]. Moreover, LNV also affect ongoing pregnancy rates [31][32][33][34], miscarriage rates [31,33,[35][36][37], and malformation in offspring [38,39].…”

Section: Introductionmentioning

confidence: 99%

The impact of paternal factors on cleavage stage and blastocyst development analyzed by time-lapse imaging—a retrospective observational study

Neyer

Zintz

Stecher

et al. 2015

J Assist Reprod Genet

View full text Add to dashboard Cite

show abstract

“…Furthermore, we demonstrated that HA may speed up the time-consuming Intracytoplasmic Morphologically Selected Sperm Injection (IMSI) [22,23]. In the present study we assessed the clinical outcome of a larger number of HA-ICSI treatments.…”

Section: Discussionmentioning

confidence: 93%

Efficiency of hyaluronic acid (HA) sperm selection

Parmegiani

Cognigni

Ciampaglia

et al. 2009

J Assist Reprod Genet

117

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“…Several publications reported that the IMSI procedure is positively associated with pregnancy rates in couples with previous and repeated implantation failures [6,7,9,34] and in patients with an elevated degree of DNA fragmented spermatozoa [27,48]. Moreover, a recently published meta-analysis showed that the IMSI procedure is associated with improved embryo quality, implantation, pregnancy and miscarriage rates [40].…”

Section: Introductionmentioning

confidence: 99%

The predictive value of high-magnification sperm morphology examination on ICSI outcomes in the presence of oocyte dysmorphisms

Setti

Braga

Figueira

et al. 2012

J Assist Reprod Genet

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Purpose To evaluate the relationship between oocyte dysmorphisms and IMSI outcomes Methods Data of IMSI cycles performed in 332 patients were included in this study. Patients were included only if presented more than four and less than 30 oocytes upon oocyte retrieval. Patients who underwent IMSI were matched, concerning female age and sperm parameters, with patients who underwent ICSI in the same period (n0332). The two groups (ICSI and IMSI) were compared with regard to treatment outcomes. The influence of IMSI on fertilization and embryo quality on D3 and D5, when oocyte dysmorphisms were present was analyzed. Results A total of 6444 oocytes were morphologically evaluated and injected. Regardless of the oocyte quality, IMSI performance was a determinant of the increased odds of development to high quality embryo on D3 (OR: 1.98; CI: 1.54-2.56) and D5 (OR: 3.27; CI: 1.61-6.66). Conclusions The selection of a morphologically normal spermatozoon under high-magnification is associated with increased embryo quality, regardless of the oocyte morphology. The injection of a spermatozoon, selected under highmagnification, into a morphologically normal oocyte leads to the highest probability of developing high quality embryos.

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Pregnancy rates are higher with intracytoplasmic morphologically selected sperm injection than with conventional intracytoplasmic injection

Cited by 348 publications

References 19 publications

The impact of paternal factors on cleavage stage and blastocyst development analyzed by time-lapse imaging—a retrospective observational study

The impact of paternal factors on cleavage stage and blastocyst development analyzed by time-lapse imaging—a retrospective observational study

Efficiency of hyaluronic acid (HA) sperm selection

The predictive value of high-magnification sperm morphology examination on ICSI outcomes in the presence of oocyte dysmorphisms

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