Pregnancy Rates for Embryos Transferred from Early Postpartum Beef Cows into Recipients with Normal Estrous Cycles1

Schrick, F. N.; Inskeep, E. K.; Butcher, R. L.

doi:10.1095/biolreprod49.3.617

Cited by 56 publications

(31 citation statements)

References 30 publications

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“…This negative correlation is consistent with previous in vivo studies [32,34] in which PGF2α had a detrimental effect on embryonic survival. Schrick et al [34] showed that a high concentration of PGF2α was negatively correlated with embryo quality. In vitro culture of embryos with PGF 2α reduced pre-compacted and compacted embryos development and decreased hatching [32].…”

Section: Discussionsupporting

confidence: 92%

Effect of superovulation on uterine and serum biochemical parameters and its potential association with transferable embryos in Holstein dairy cows

Rasolomboahanginjatovo

Chorfi

Dupras³

et al. 2014

J Vet Sci

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The objective of this study was to determine the effects of superovulation (SOV) on serum and uterine biochemical parameters, uterine bacteriology and cytology and number of transferable embryos (TE). Dairy cows were placed on a Presynch/CIDR Synch protocol. The SOV group was superovulated, induced in estrus, and inseminated, whereas the control group was induced in estrus and inseminated without SOV. Uterine bacteriology and cytology and uterine and serum biochemical parameters were measured at day 7 of the estrous cycle to start the SOV protocol, as well as on the day of embryo recovery (DER). The SOV group produced 7.5 ± 6.7 oocytes/embryos, of which 3.4 ± 4.7 were TE. Serum urea and E2 and uterine Glu, CK, LDH, TP, P4 and PGFM in the control group and serum P4 and PGFM and uterine LDH and PGFM in the SOV group were significantly higher (p < 0.01) at DER than day 7. At DER, uterine urea, LDH, PGFM and TP and serum urea, LDH, PGFM, and P4 concentrations were higher (p < 0.01) in the SOV group than the control. There was no significant variation in uterine bacteriology or cytology. Overall, these results infer that SOV affects both serum profile and uterine secretions, and that these changes may influence the number of TE.

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Section: Discussionsupporting

confidence: 92%

Effect of superovulation on uterine and serum biochemical parameters and its potential association with transferable embryos in Holstein dairy cows

Rasolomboahanginjatovo

Chorfi

Dupras³

et al. 2014

J Vet Sci

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“…The apparent timing of embryo loss in this study seemed to coincide with increased PGF 2α secretion as observed by Cooper et al (1991). Moreover, in a similar experiment, there was a negative correlation between the quality of embryos on Day 6 and concentrations of PGF 2α in uterine flushings (that were higher for cows with short luteal phases; Schrick et al 1993). It was therefore suggested that PGF 2α itself could have a direct embryo toxic effect; however, pregnancy rates of cows with a short luteal phase that were supplemented with progestagen did not increase when an inhibitor of PGF 2α synthesis was injected every 8 h on Days 4 to 9.…”

Section: Short Duration Of the Luteal Phasesupporting

confidence: 67%

Factors affecting embryo survival and strategies to reduce embryonic mortality in cattle

Bilodeau‐Goeseels¹,

Kastelic²

2003

Can. J. Anim. Sci.

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Bilodeau-Goeseels, S. and Kastelic, J. P. 2003. Factors affecting embryo survival and strategies to reduce embryonic mortality in cattle. Can. J. Anim. Sci. 83: 659-671. Embryonic mortality in cattle is the death of the conceptus before Day 42 of pregnancy. Estimates of embryonic mortality varied greatly, ranging from 10 to 40% in first-service cattle to 65% in repeat-breeder cows. This paper reviews endogenous causes of embryonic mortality, including chromosomal abnormalities, inadequate corpus luteum function and the influence of follicular development on fertility. External causes of embryonic mortality, including heat stress and nutrition, are also reviewed; these factors act by modifying the follicular environment (thereby affecting oocyte quality) or by creating a hostile uterine environment. Strategies to reduce embryonic mortality, including good management practices and supplementation with progesterone or interferon-tau, are discussed. From a practical perspective, improved knowledge of the causes of embryonic mortality and regulation of follicular growth and corpus luteum function should result in the development of improved, cost-effective hormonal regimes that effectively synchronize estrus and ovulation and reduce embryonic mortality, thereby benefiting the cattle industry.Key words: Cattle, reproduction, fertility, embryo development, embryo mortality Bilodeau-Goeseels, S. et Kastelic, J. P. 2003. Les facteurs affectant la survie de l'embryon et les stratégies pour réduire la mortalité embryonnaire chez la vache. Can. J. Anim. Sci. 83: 659-671. Chez la vache, la mortalité embryonnaire se définie comme étant la perte de l'embryon avant le Jour 42 de la gestation. Les estimations de la mortalité embryonnaire varient grandement, allant de 10 à 40 % chez les vaches à fertilité normale jusqu'à 65 % chez les vaches à fertilité réduite. L'article que voiçi examine les causes endogènes de la mortalité embryonnaire incluant les anomalies chromosomales, le fonctionnement inadéquat du corpus luteum ainsi que l'influence du développement folliculaire sur la fertilité. Des causes externes telles que le stress thermique et la nutrition sont aussi passées en revue; ces facteurs agissent en modifiant l'environnement folliculaire ce qui conduit à une diminution de la qualité de l'ovocyte; ou en créant un environnement utérin hostile pour l'embryon. Des stratégies pour réduire la mortalité embryonnaire telles que la bonne gestion et la supplémentation avec de la progestérone ou de l'interféron-tau sont aussi discutées. Du point de vue pratique, l'augmentation des connaissances sur les causes de la mortalité embryonnaire ainsi que sur la régulation de la croissance folliculaire et du fonctionnement du corpus luteum permettra le développement de régimes hormonaux améliorés et économiques produisant des hauts niveaux de synchronization de l'estrus et/ou de l'ovulation et qui réduiront la mortalité embryonnaire, ce don't bénéficieront les industries laitières et bovines. Mots clés:Bovin, reproduction, fertilité, dévelo...

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“…PGF 2␣ interferes with early embryonic development in the rabbit [47], rat [48], and cow [49] when added to culture medium and could be the embryotoxin in cows undergoing early luteal regression. Indeed, Schrick et al [50] found higher concentrations of PGF 2␣ in uterine flushings of postpartum beef cows on Day 6 of a short luteal phase.…”

Section: Discussionmentioning

confidence: 99%

Increased Expression of Insulin-Like Growth Factor Binding Protein-1 During Induced Regression of Bovine Corpora Lutea1

Sayre

Taft

Inskeep

et al. 2000

Biology of Reproduction

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Three experiments were conducted to examine gene expression during induced luteal regression in the cow; the initial purpose was the identification of potential embryotoxins. In experiment 1, changes in gene expression in the corpus luteum (CL) were identified by differential display reverse transcription-polymerase chain reaction (DD-PCR) during the first 72 h of luteal regression in cows treated with prostaglandin F(2alpha) (PGF(2alpha)) on Days 4-7 after estrus. Expression of insulin-like growth factor-binding protein-1 (IGFBP-1) was up-regulated, with greatest expression at 24 h (P < 0.05) after treatment with PGF(2alpha) began. In experiment. 2, IGFBP-1 and its mRNA were quantified in CL collected 24 or 48 h after treatment with PGF(2alpha) on Day 4 or 10 after estrus. Because local mechanisms for exchange of hormones between the ovary and uterus are known in ruminants, uterine flushings were assayed for IGFBP-1 to seek evidence of local transfer of luteal IGFBP-1 to the uterus. IGFBP-1 mRNA was increased (P < 0.05) in CL 24 h after treatment when PGF(2alpha) that began on Day 10, and by 48 h after treatment that began on Day 4. Concentrations of IGFBP-1 increased (P < 0.05) in a pattern similar to mRNA, by 24 h on Day 10, and by 48 h on Day 4. Concentrations of IGFBP-1 in uterine flushings did not change on either day. Concentrations of progesterone decreased (P < 0.05) by 8 h after treatment with PGF(2alpha) that began on Day 10, but not until 24 h after treatment that began on Day 4. In experiment 3, cows received either saline or PGF(2alpha) and CL were collected 2 or 10 h after a single treatment, or 2 h after a second treatment that was given 8 h after the first. Expression of IGFBP-1 was increased by 2 h after treatment with PGF(2alpha) on both Days 4 and 10 after estrus. In conclusion, secretion of IGFBP-1 is increased during luteolysis, and may inhibit the steroidogenic effects of insulin-like growth factor-I (IGF-I), but no evidence was found to implicate IGFBP-1 in the embryotoxic effect of regressing CL.

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Pregnancy Rates for Embryos Transferred from Early Postpartum Beef Cows into Recipients with Normal Estrous Cycles1

Cited by 56 publications

References 30 publications

Effect of superovulation on uterine and serum biochemical parameters and its potential association with transferable embryos in Holstein dairy cows

Effect of superovulation on uterine and serum biochemical parameters and its potential association with transferable embryos in Holstein dairy cows

Factors affecting embryo survival and strategies to reduce embryonic mortality in cattle

Increased Expression of Insulin-Like Growth Factor Binding Protein-1 During Induced Regression of Bovine Corpora Lutea1

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