Pregnancy Results Following Treatment With Clomiphene Citrate

Abstract

Summary Three hundred and twenty‐eight infertile women were selected for treatment with clomiphene citrate because the sole cause of their infertility was absent or infrequent ovulation; this was induced in 66.4 per cent with an overall pregnancy rate of 52 per cent. Six types of cytological response to clomiphene are described together with the effect on cervical mucus. Improved results were obtained by a more careful selection of patients and with greater use of combined therapy with human chorionic gonadotrophin, when the ovulatory response rose to 74 per cent with pregnancy rate of 63 per cent.

Antioestrogens: A Review

“…Following the early encouraging papers many series reporting experience with clomiphene have been published (Roy et at., 1963;Swyer, 1963;Charles et al, 1963Charles et al, , 1966Ullery, 1964;Naville et al, 1964;Kistner, 1965aKistner, , b, 1966; Vorys et at., Townsend et al, 1966;Johnson et al, 1966;Whitelaw, 1966;Bishop, 1967Bishop, , 1970Bishop, , 1972 & Osmond-Clarke, 1971). Kistner (1965b) attempted to group his anovulatory patients according to histological appearance of the endometrium-atrophic, proliferative or hyperplastic : although he reported success in all groups, the proliferative endometrium group seemed to do best.…”

Scientific and Clinical Aspects of Fertilization and Implantation

“…Out of 200 such induced ovulations at Chelsea Hospital for Women, 52 women (26%) showed this persistent response and none conceived even when the postovular phase was lengthened by a progestogen. However, when we used HCG 30 of these women (57 %) became pregnant (Murray & Osmond-Clarke 1971). The use of this combined treatment was first published independently and simultaneously by Bishop et al (1966) and Kistner (1966).…”