Pregnancy zone protein is a carrier and modulator of placental protein-14 in T-cell growth and cytokine production

Skornicka, Erin L.; Kiyatkina, Nadya; Weber, Matthew C.; Tykocinski, Mark L.; Koo, Peter H.

doi:10.1016/j.cellimm.2005.03.007

Cited by 58 publications

(46 citation statements)

References 68 publications

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“…This protein is fundamental for a successful pregnancy, since it avoids that maternal immune system attacks the allogeneic fetus. 45,46 The presence of A2M and PZP in the secretome of Muse cells may indicate that these cells may have significant immunomodulator capacity.…”

Section: Muse Cells Secrete Factors That May Play a Role In Stem Cellmentioning

confidence: 99%

The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation

et al. 2016

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Mesenchymal stromal cells (MSCs) are a heterogeneous population, which contain several cell phenotypes: mesenchymal stem cells, progenitor cells, fibroblasts and other type of cells. Previously, we identified unique stem cells that we named multilineage-differentiating stress enduring (Muse) cells as one to several percent of MSCs of the bone marrow, adipose tissue and dermis. Among different cell populations in MSCs, Muse cells, positive for pluripotent surface marker SSEA-3, may represent cells responsible for pluripotent-like property of MSCs, since they express pluripotency genes, able to differentiated into triploblastic cells from a single cells and are self-renewable.MSCs release biologically active factors that have profound effects on local cellular dynamics. A thorough examination of MSC secretome seems essential for understanding the physiological functions exerted by these cells in our organism and also for rational cellular therapy design. In this setting, studies on secretome of Muse cells may shed light on pathways that are associated with their specific features.Our findings evidenced that secretomes of MSCs and Muse cells contain factors that regulate extracellular matrix remodeling, ox-redox activities and immune system. Muse cells appear to secrete factors that may preserve their stem cell features, allow survival under stress conditions and may contribute to their immunomodulation capacity.In detail, the proteins belonging to protein kinase A signaling, FXR/RXR activation and LXR/RXR activation pathways may play a role in regulation of Muse stem cell features. These last 2 pathways together with proteins associated with antigen presentation pathway and coagulation system may play a role in immunomodulation.

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Section: Muse Cells Secrete Factors That May Play a Role In Stem Cellmentioning

confidence: 99%

The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation

et al. 2016

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“…Both α 2 M and PZP are reported to potentiate the ability of PP14 to inhibit Th1 cells, but comparatively, PZP appears to be more efficient at performing this role (Skornicka et al, 2004) (Fig. 2).…”

Section: Disease Implicationsmentioning

confidence: 99%

“…It has been suggested that PZP is upregulated under conditions of increased cellular turnover to control the activities of intracellular proteases such as elastases and chymotrypsin-like enzymes, but there is currently little evidence to support this claim and it is feasible that the biological importance of PZP is related to an alternative role. One suggestion is that during pregnancy PZP works synergistically with placental protein-14 (PP14) to inhibit T-helper 1 (Th1) cell activation, thereby, protecting the allogenic foetus from maternal immune system attack (Skornicka et al, 2004) (Fig. 2).…”

Section: Biological Functionsmentioning

confidence: 99%

PZP and PAI-2: Structurally-diverse, functionally similar pregnancy proteins?

Wyatt

Cater

Ranson

2016

The International Journal of Biochemistry & Cell Biology

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Pregnancy zone protein (PZP) and plasminogen activator inhibitor type 2 (PAI-2) are two multifunctional proteins that are elevated in normal pregnancy and numerous other inflammatory states. Both proteins were originally identified as protease inhibitors, but current evidence supports the notion that they may also function as modulators of T-helper cells and/or extracellular chaperones. Exacerbated inflammation, fibrinolytic disturbances and misfolded proteins are all implicated in the pathology of preeclampsia, a leading cause of maternal and foetal mortality and morbidity. Notably, reduced levels of PZP or PAI-2 are associated with preeclampsia and clarification of their diverse functions in normal pregnancy could provide much needed insight regarding the pathogenesis of this disorder. Given that inflammation and protein misfolding underlie the pathology of a very large number of disorders, the contributions of PZP and PAI-2 to extracellular proteostasis and immunoregulation could be broad-reaching. Given that inflammation and protein misfolding underlie the pathology of a very large number of disorders, the contributions of PZP and PAI-2 to extracellular proteostasis and immunoregulation could be broad-reaching.

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“…PZP is found in blood serum, the zone of the uteroplacental bed, amniotic sac, macrophages, and syncytiotrophoblast cells. PP14 protein is discovered in the endometrium, decidua, blood serum and amniotic fluid [117]. PZP and PP14 synergically increase T cell immunosuppression, displayed in reduction of T cell proliferative activity and reduction of IL-2 secretion by activated T cells.…”

Section: Impact Of Placenta and Decidua Cells On T Lymphocyte Functiomentioning

confidence: 99%

“…They have no effect on IL-4 secretion by activated T cells. Thus, they can promote Th1 proliferation inhibiting at pregnancy against the background of no negative effect on Th2 cell clonal proliferation [74,117]. PZP is a protease inhibitor of wide specify, it effects lymphocyte migration, their cytotoxic activity and secretory specifics.…”

Section: Impact Of Placenta and Decidua Cells On T Lymphocyte Functiomentioning

confidence: 99%

THE ROLE OF THE DIFFERENT SUBPOPULATIONS OF CD4<sup>+</sup>Т LYMPHOCYTES DURING PREGNANCY

Игоревич¹,

Степанова²,

Selkov³

2016

Med. immunol.

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Pregnancy zone protein is a carrier and modulator of placental protein-14 in T-cell growth and cytokine production

Cited by 58 publications

References 68 publications

The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation

The secretome of MUSE cells contains factors that may play a role in regulation of stemness, apoptosis and immunomodulation

PZP and PAI-2: Structurally-diverse, functionally similar pregnancy proteins?

THE ROLE OF THE DIFFERENT SUBPOPULATIONS OF CD4<sup>+</sup>Т LYMPHOCYTES DURING PREGNANCY

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