Pregnane Steroids from the Leaves of Melia Azedarach and Apoptotic Activity against T47D Cells

Ervina, Martha; Poerwono, Hadi; Widyowati, Retno; Otsuka, Hideaki; Matsunami, Katsuyoshi; Sukardiman, Sukardiman

doi:10.31557/apjcp.2021.22.6.1967

Cited by 5 publications

(1 citation statement)

References 19 publications

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“…Hence, the activation of ER-α by estrogens is considered to be accountable for enhanced proliferation, making estrogen receptor ER-α, a target in endocrine treatment (Ervina et al, 2021). ER-α status has been used to recognise breast cancer patients who are likely to respond to tamoxifen, the endocrine agent most commonly used to block the effects of estrogen at all stages of breast cancer, particularly in post-menopausal patients (Arnesen et al, 2021).…”

Section: Graphical Abstract Introductionmentioning

confidence: 99%

In-silico Study of Novel Dimeric flavonoid (OC251FR2) from the Seeds of Garcinia kola Heckel (Clusiaceae) Against Alpha Estrogen Receptor (ER-α) of Breast cancer

Eugene-Osoikhia,

Odozi,

Yeye

et al. 2024

Preprint

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In silico approach was used to investigate the inhibitory activities of a novel dimeric flavanonol OC251FR2 (3,3'-oxybis(5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one)-3,3'-oxybis(5,7-dihydroxy-2-(4-hydroxyphenyl)chroman-4-one) isolated from the chloroform fraction of Garcinia kola, against alpha Estrogen receptor (ER-α); a major contributor to the growth of breast cancer. The docking was conducted using Maestro module 13.5 to obtained the ER-α PDB (5W9C) from NCBI. The OC251FR2 was docked using ligprep module with 4-hydroxytamoxifen being the reference drug. The qikpro was used to investigate the drug-likeliness while ligand docking and induced fit docking were used to investigate the interaction and binding affinity of the ligands with the active sites of the PDB. The result shows that the isolated OC251FR2 interact more with amino acids in the active sites via H-bond, pi-pi interaction than the reference drug 4-Hydroxytamoxifen. The drug-likeliness determined by qikpro shows that OC251FR2 violated three of the Lipinski rules of 5, and also have percent oral absorption. The quantum mechanics values show that OC251FR2 have similar properties comparable to the reference drug 4-hydroxytamoxifen. Hence, can serve as potential lead against alpha Estrogen receptor (ER-α).

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Section: Graphical Abstract Introductionmentioning

confidence: 99%

In-silico Study of Novel Dimeric flavonoid (OC251FR2) from the Seeds of Garcinia kola Heckel (Clusiaceae) Against Alpha Estrogen Receptor (ER-α) of Breast cancer

Eugene-Osoikhia,

Odozi,

Yeye

et al. 2024

Preprint

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Medicinal plants cultivated in Egypt with anticancer potential; a systematic review

Elshnoudy,

Elkhouly,

Masoud

et al. 2024

Phytochem Rev

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The increase in cases of various cancers, the number of cancer patients, and the serious side effects of current chemical treatments have encouraged researchers to discover novel and more effective drugs from plant sources. In this review, PubMed and Scopus were searched for English-language peer-reviewed articles published since 1994, using the keywords: Medicinal plants, Egypt, and Cancer. The inclusion criteria for this systematic review were English peer-reviewed original research articles. A total of 286 studies were included. Studies have shown that the active compounds in certain plants can have anticancer activities by various mechanisms, such as cell cycle arrest, apoptosis induction, and antioxidant effects. Additionally, it is evident that medicinal plants can act as inhibitors of cancer cells. Plants can also act as immune checkpoint inhibitors, which inhibit proteins such as PD-L1 on tumor cells, PD-1 and CTLA-4 on T cells, and help to regulate immune responses. This review also discusses the efficacy of nanoparticles of these plants against cancer cells. The findings indicate the high potential of investigating the bioactive anticancer components of Egyptian medicinal plants for advancing novel treatments that are more effective in combating cancer. The extracts and active compounds of the medicinal plants detailed in this review could provide the foundation for further clinical trials to be conducted, to develop new anticancer drugs.

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Synthesis, characterization of new heterocyclic compound: pyrazolyl hydrazino quinoxaline derivative: 3-[5-(hydroxy1methyl)-1-phenylpyrazol-3-yl]-2-[2, 4, 5-trimethoxybenzylidine] hydrazonyl-quinoxaline of potent antimicrobial, antioxidant, antiviral, and antitumor activity

Sallam

Aboulnaga

Samy

et al. 2023

Journal of Molecular Structure

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Pregnane Steroids from the Leaves of Melia Azedarach and Apoptotic Activity against T47D Cells

Cited by 5 publications

References 19 publications

In-silico Study of Novel Dimeric flavonoid (OC251FR2) from the Seeds of Garcinia kola Heckel (Clusiaceae) Against Alpha Estrogen Receptor (ER-α) of Breast cancer

In-silico Study of Novel Dimeric flavonoid (OC251FR2) from the Seeds of Garcinia kola Heckel (Clusiaceae) Against Alpha Estrogen Receptor (ER-α) of Breast cancer

Medicinal plants cultivated in Egypt with anticancer potential; a systematic review

Synthesis, characterization of new heterocyclic compound: pyrazolyl hydrazino quinoxaline derivative: 3-[5-(hydroxy1methyl)-1-phenylpyrazol-3-yl]-2-[2, 4, 5-trimethoxybenzylidine] hydrazonyl-quinoxaline of potent antimicrobial, antioxidant, antiviral, and antitumor activity

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