PRELIMINARY ANALYSIS OF INTERLEUKIN-6 CHANGES IN PRE- AND POSTOPERATIVE IN DIABETIC PATIENTS WITH BMI<35 SUBMITTED TO PARTIAL DUODENAL SWITCH

Abstract

Background: Studies related to obesity have shown association with metabolic syndrome. Data showing that obesity is capable to cause low grade chronic inflammation, without its classic signs and symptoms, call attention to researches to study different cells types and the mechanism of the inflammatory process. Aim: To evaluate the variation of glycated hemoglobin (HbA1c) and the pro-inflammatory cytokine interleukin-6 (IL6) in diabetic patients with BMI <35 kg/m2 in the pre and postoperative of partial duodenal switch. Method: Nine patients were studied before and one year after the operation and the variation of the serum IL6 was measured by Elisa. The changes of HbA1c were also registered. Results: The pre-operative IL6 levels reached 65,50436±2,911993 pg/ml and one year after de operation 39,47739±3,410057 and the HbA1c average of 10,67 and 5.8 in the same period. Conclusion: The partial duodenal switch was efficient to control one year after the procedure the chronic inflammatory process caused by the diabetes mellitus type 2 with BMI <35 by dropping the IL6 levels and bringing the HbA1c to normal.

Quality of Life After Vertical Gastrectomy Evaluated by the Baros Questionnaire

“…Several studies document the influence of weight loss in improving the quality of life 2 , 9 , 13 , 16 , 18 , 26 . This improvement was described by Hachem and Brennan 16 in a systematic review finding that bariatric surgery produced better results compared with other treatments for obesity, especially in the first two years after surgery.…”

Anti-Inflammatory Effect and Toxicological Profile of Pulp Residue from the Caryocar Brasiliense, a Sustainable Raw Material

“…Studies have established that lipopolysaccharides (LPS) induce the secretion of pro-inflammatory cytokines such as TNF-α and interleukins [ 38 ]. Cytokines are signaling polypeptides used in cell communication by the immune system during the inflammatory response; they act on virtually all cell types and in mRNA synthesis [ 38 ]. Interleukin-6 (IL-6) is the most important mediator of the acute inflammatory response and is the main procoagulant cytokine [ 3 , 38 ].…”

“…Cytokines are signaling polypeptides used in cell communication by the immune system during the inflammatory response; they act on virtually all cell types and in mRNA synthesis [ 38 ]. Interleukin-6 (IL-6) is the most important mediator of the acute inflammatory response and is the main procoagulant cytokine [ 3 , 38 ]. IL-10 has anti-inflammatory and suppressive effects on most hematopoietic cells and indirectly suppresses the production of other cytokines.…”