1996
DOI: 10.1002/(sici)1097-4636(199601)30:1<53::aid-jbm8>3.0.co;2-q
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Preliminary biological evaluation of polyamidoamine (PAMAM) StarburstTM dendrimers

Abstract: PAMAM Starburst dendrimers are spherical macromolecules composed of repeating polyamidoamino units. They can be produced in successive "generations," each with a defined size, molecular weight, and number of terminal amino groups. Because of these well-defined characteristics, PAMAMs are finding utility in a variety of applications, many of which are biological in nature. Little is known, however, about the biological behavior of the PAMAMs, which is critical to their use in vivo. Generation 3 (G3; MW = 5,147;… Show more

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Cited by 564 publications
(403 citation statements)
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“…24 In vivo toxicity and immunogenicity of intact dendrimers are likely to be minimal. 25 In our experiments fractured dendrimers did not show any signs of inflammation or toxicity (Figure 2). Systemic administration of plasmid carriers leads to interactions with plasma proteins and accumulation of genes into undesired locations, mostly in the lung and liver.…”
Section: Discussionmentioning
confidence: 47%
“…24 In vivo toxicity and immunogenicity of intact dendrimers are likely to be minimal. 25 In our experiments fractured dendrimers did not show any signs of inflammation or toxicity (Figure 2). Systemic administration of plasmid carriers leads to interactions with plasma proteins and accumulation of genes into undesired locations, mostly in the lung and liver.…”
Section: Discussionmentioning
confidence: 47%
“…To date, these have been described only as gene transfer vectors for cell lines. 1,6 In this article we extend the findings to corneal ex vivo culture.…”
mentioning
confidence: 53%
“…A characteristic feature of dendrimers is their relatively low toxicity in vitro 6 and in vivo. 7 Although viral vectors are more efficient, their use in vivo is limited by immunogenicity and safety considerations.…”
Section: -Galactosidase Was Quantified By Counting Transfected Cells mentioning
confidence: 99%
See 1 more Smart Citation
“…27 S32826 was attached to a third generation (G3) PAMAM dendrimer in order to achieve a high hydrodynamic volume while not encountering the issues of higher toxicity associated with higher generations of dendrimers. 22,28 Herein we report the synthesis of a novel drug conjugate of the potent autotaxin inhibitor, S32826 with a third generation PAMAM dendrimer. The conjugate inhibits autotaxin in vitro, suppresses autotaxin-induced cell migration, and potentiates apoptosis induced by carboplatin.…”
mentioning
confidence: 99%