Preliminary Characterization, Antioxidant and Hepatoprotective Activities of Polysaccharides from Taishan Pinus massoniana Pollen

Zhou, Changming; Yin, Shaojie; Yu, Zhongfang; Feng, Yue; Wei, Kai; Ma, Wei; Ge, Lijiang; Yan, Zhiying; Zhu, Rui‐Liang

doi:10.3390/molecules23020281

Cited by 22 publications

(8 citation statements)

References 39 publications

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“…Finding reliable and potent antioxidants is therefore crucial. The potential of natural compounds, such as phenols and flavonoids, to heal liver damage has reportedly been linked to their antioxidant activity [99][100][101][102].…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of Mandarin Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin on Acetaminophen-Induced Hepatonephrotoxicity in Wistar Rats

Eldin

Fahim

Ahmed

et al. 2022

Oxidative Medicine and Cellular Longevity

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Acetaminophen, also known as N-acetyl-para-aminophenol (NAPAP), is a traditional antipyretic and analgesic that is used extensively around the world to treat colds and fevers. However, a NAPAP excess causes rapid, severe liver and kidney damage. The goal of the study was to examine the protective effects and determine the mechanisms of action of MPHE, hesperidin, and quercetin in NAPAP-induced hepatorenal damage in Wistar rats. Male Wistar rats received a 0.5 g/kg oral supplement of NAPAP every other day for a period of four weeks. During the same period of NAPAP supplementation, MPHE (50 mg/kg), quercetin (20 mg/kg), and hesperidin (20 mg/kg) were administered to rats receiving NAPAP. MPHE, quercetin, and hesperidin treatments significantly improved liver function in NAPAP-supplemented rats. The high serum levels of aminotransferases, alkaline phosphatase, lactate dehydrogenase, and γ-glutamyl transferase as well as total bilirubin were significantly reduced, while the levels of suppressed serum albumin were significantly increased, demonstrating this improvement. Treatments utilizing these natural substances significantly enhanced kidney function as seen by a considerable decline in the increased blood levels of urea, uric acid, and creatinine. Additionally, the injection of MPHE, hesperidin, and quercetin resulted in a decrease in the quantity of lipid peroxides while increasing the activities of superoxide dismutase, glutathione peroxidase, and glutathione-S-transferase in the liver and kidneys. The treatments markedly abated the NAPAP-induced liver and kidney histological perturbations and reduced the NAPAP-induced serum tumor necrosis factor-α level and liver and kidney proapoptotic protein 53 and caspase 3 expressions. Otherwise, serum interleukin-4 level significantly increased by treatments. The MPHE, hesperidin, and quercetin treatments resulted in marked decrease in liver and kidney histopathological scores including inflammation, necrosis, apoptosis, and congestion. In conclusion, the MPHE, quercetin, and hesperidin may induce hepatonephropreventive impacts in NAPAP-supplemented rats via enhancing the antioxidant defense system, anti-inflammatory activity, and antiapoptotic action.

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Section: Discussionmentioning

confidence: 99%

Preventive Effects of Mandarin Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin on Acetaminophen-Induced Hepatonephrotoxicity in Wistar Rats

Eldin

Fahim

Ahmed

et al. 2022

Oxidative Medicine and Cellular Longevity

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“…It has been reported that the capacity of natural products including phenols, flavonoids, polysaccharides, etc. in treating liver injury may be due to its antioxidant activity [44, 50–52]. In order to study the antioxidant activity of natural products, different assays based on chemical methods such as DPPH radical scavenging activity and reducing power have been applied [53, 54].…”

Section: Discussionmentioning

confidence: 99%

The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice

Liu

Luo

et al. 2019

Evidence-Based Complementary and Alternative Medicine

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Acute liver injury is a common consequence of taking overdose of acetaminophen (APAP). The aim of this study was to evaluate the antioxidant activity and hepatoprotective effect of a mangrove plant Sonneratia apetala fruit extract (SAFE) on APAP-induced liver injury in mice. Mice were orally pretreated with SAFE (100, 200, and 400 mg/kg) daily for one week. The control and APAP groups were intragastrically administered with distilled water, and NAC group was treated with N-Acetyl-L-cysteine (NAC) before APAP exposure. The results manifested that SAFE significantly improved survival rates, attenuated hepatic histological damage, and decreased the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in serum in APAP-exposed mice. SAFE treatment also increased glutathione (GSH) level and glutathione peroxidase (GSH-Px) activity, enhanced catalase (CAT), and total antioxidant capacity (T-AOC), as well as reducing malondialdehyde (MDA) level in liver. In addition, the formation of tumor necrosis factor-alpha (TNF-α), interleukin 6 (IL-6), and elevation of myeloperoxidase (MPO) in APAP-exposed mice were inhibited after SAFE treatment. And SAFE also displayed high DPPH radical scavenging activity and reducing power in vitro. The main bioactive components of SAFE such as total phenol, flavonoid, condensed tannin, and carbohydrate were determined. The current study proved that SAFE exerted potential protective effect against APAP-induced acute liver injury, which might be associated with the antioxidant and anti-inflammatory activities of SAFE.

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“…Исследователями отмечается [3], что за последние 20 лет наблюдается активизация фармакологических и клинических исследований сосновой пыльцы, о чем свидетельствует рост количества публикаций на эту тему. Установлены иммуномодулирующая, противовирусная, противовоспалительная, антиоксидантная и гепатопротекторная активности экстрактов [4][5][6][7] и полисахаридов [8][9][10][11][12] пыльцы азиатских видов сосен. Исследование пыльцы P. sylvestris и P. pumila, проведенное авторами ранее, показало содержание в ней флавоноидов, аминокислот, аскорбиновой кислоты, макро-и микроэлементов [13].…”

Section: Introductionunclassified

Elemental composition of microstrobili and sprouts of <i>Pinus sylvestris, Pinus sibirica</i> and <i>Pinus pumila</i>

Ширеторова

Erdyneeva

Раднаева

2023

Izvestiâ vuzov. Prikladnaâ himiâ i biotehnologiâ

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In recent years, the popularity of dietary supplements based on pine pollen has significantly increased due to over a thousand years of its use in Chinese traditional medicine and diverse biological activity. Microstrobili are harvested prior to flowering in order to obtain pine pollen, and, following its separation, waste comprising empty microstrobili in the amount of 90–95% of the mass of raw material is formed. In this work, the elemental composition of Pinus sylvestris, P. sibirica and P. pumila microstrobili obtained following the separation of pollen (empty microstrobili (EM) was determined and compared with pharmacopoeial raw material, i.e., P. sylvestris sprouts. The elemental composition was analysed using atomic absorption spectroscopy with preliminary acid mineralisation in a microwave system. A comparative analysis of the elemental composition showed that EM contains a significant amount of K (8710–10187 mg/kg), Mg (627–1079 mg/kg), Mn (129–179 mg/kg), as well as Zn (37–67 mg/kg) and Cu (7.4–10.3 mg/kg). The series of accumulation of chemical elements was identical for microstrobili and sprouts of the studied pine species (K>Mg>Ca>Mn>Fe~Zn>Na>Cu>Ni~Cr>Co>Pb>Cd>Hg). EM can be used to enrich the diet with macroand microelements such as K, Mg, Mn, Fe, Zn and Cu. The content of toxic Cd, Pb and Hg was below the maximum permissible standards for medicinal plant raw materials and dietary supplements thereof. Obtained for the first time, data on the elemental composition of EM of P. sylvestris, P. sibirica, P. pumila and sprouts of P. sibirica and P. pumila can be used for further sanitary measurements of a new type of raw material.

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Preliminary Characterization, Antioxidant and Hepatoprotective Activities of Polysaccharides from Taishan Pinus massoniana Pollen

Cited by 22 publications

References 39 publications

Preventive Effects of Mandarin Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin on Acetaminophen-Induced Hepatonephrotoxicity in Wistar Rats

Preventive Effects of Mandarin Fruit Peel Hydroethanolic Extract, Hesperidin, and Quercetin on Acetaminophen-Induced Hepatonephrotoxicity in Wistar Rats

The Protective Effect of Sonneratia apetala Fruit Extract on Acetaminophen-Induced Liver Injury in Mice

Elemental composition of microstrobili and sprouts of <i>Pinus sylvestris, Pinus sibirica</i> and <i>Pinus pumila</i>

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