Preliminary Clinical Experience with a Combined Automated Breast Ultrasound and Digital Breast Tomosynthesis System

Larson, Eric; Lee, Won Mean; Roubidoux, Marilyn A.; Goodsitt, Mitchell M.; Lashbrook, Chris; Davis, C. E.; Kripfgans, Oliver D.; Carson, Paul L.

doi:10.1016/j.ultrasmedbio.2017.12.003

Cited by 13 publications

(6 citation statements)

References 20 publications

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“…In this way the alterations identified with DBT could thus be better investigated without having to return the patient at a later time and without even having her move. These still initial experiences must be validated on a large scale, but from the first results the technique seems to be of sufficient quality to identify malignant lesions and could lead to important logistical and economic advantages, especially in the screening setting [ 45 , 46 ].…”

Section: Ultrasoundmentioning

confidence: 99%

A Review of Breast Imaging for Timely Diagnosis of Disease

Bicchierai

Naro

Benedetto

et al. 2021

IJERPH

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Breast cancer (BC) is the cancer with the highest incidence in women in the world. In this last period, the COVID-19 pandemic has caused in many cases a drastic reduction of routine breast imaging activity due to the combination of various factors. The survival of BC is directly proportional to the earliness of diagnosis, and especially during this period, it is at least fundamental to remember that a diagnostic delay of even just three months could affect BC outcomes. In this article we will review the state of the art of breast imaging, starting from morphological imaging, i.e., mammography, tomosynthesis, ultrasound and magnetic resonance imaging and contrast-enhanced mammography, and their most recent evolutions; and ending with functional images, i.e., magnetic resonance imaging and contrast enhanced mammography.

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Section: Ultrasoundmentioning

confidence: 99%

A Review of Breast Imaging for Timely Diagnosis of Disease

Bicchierai

Naro

Benedetto

et al. 2021

IJERPH

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“…Another important innovation is the development of new equipment, like the combination of DBT with automated breast ultrasound: its goal is to implement sensitivity in patients with dense breast; currently, to our knowledge, there are only few data available on small groups of patients in this setting [82,83], but this new technologies would seem to provide promising results.…”

Section: New Perspectivesmentioning

confidence: 99%

Digital breast tomosynthesis: a state-of-the-art review

Orsi¹,

Cellina²,

Rosti³

et al. 2019

Nucl Med Biomed Imaging

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Digital Breast Tomosynthesis (DBT) is an X-ray mammography technique where multiple low-dose projection images of the breast are reconstructed in multiple tomographic images creating a semi-3D mammogram. This enables the visualization of a sequential set of thin sections of the breast, overcoming the masking effect of overlying fibroglandular breast tissue, then improving carcinoma detection and reducing false-positive cases. This review aims at describing current DBT technique, analyzing DBT in clinical practice and providing an overview of published studies on clinical experience with DBT in the screening and diagnostic settings.

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“…Therefore, ultrasound and MRI are used as secondary imaging tools in cases where mammography is suboptimal to visualize additional breast cancers [ 4 , 5 , 6 ]. Neither ultrasound or MRI have ionizing radiation, but ultrasound suffers from a limited depth of penetration which can miss some malignancies deeper in the breast [ 7 , 8 ]. In contrast, MRI acquires full 3D images of the breast with high spatial resolution and excellent soft tissue contrast that is capable of distinguishing between fat, muscle, organs, and tumors.…”

Section: Introductionmentioning

confidence: 99%

PEGylation of Metal Oxide Nanoparticles Modulates Neutrophil Extracellular Trap Formation

et al. 2022

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Novel metal oxide nanoparticle (NP) contrast agents may offer safety and functionality advantages over conventional gadolinium-based contrast agents (GBCAs) for cancer diagnosis by magnetic resonance imaging. However, little is known about the behavior of metal oxide NPs, or of their effect, upon coming into contact with the innate immune system. As neutrophils are the body’s first line of defense, we sought to understand how manganese oxide and iron oxide NPs impact leukocyte functionality. Specifically, we evaluated whether contrast agents caused neutrophils to release web-like fibers of DNA known as neutrophil extracellular traps (NETs), which are known to enhance metastasis and thrombosis in cancer patients. Murine neutrophils were treated with GBCA, bare manganese oxide or iron oxide NPs, or poly(lactic-co-glycolic acid) (PLGA)-coated metal oxide NPs with different incorporated levels of poly(ethylene glycol) (PEG). Manganese oxide NPs elicited the highest NETosis rates and had enhanced neutrophil uptake properties compared to iron oxide NPs. Interestingly, NPs with low levels of PEGylation produced more NETs than those with higher PEGylation. Despite generating a low rate of NETosis, GBCA altered neutrophil cytokine expression more than NP treatments. This study is the first to investigate whether manganese oxide NPs and GBCAs modulate NETosis and reveals that contrast agents may have unintended off-target effects which warrant further investigation.

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Preliminary Clinical Experience with a Combined Automated Breast Ultrasound and Digital Breast Tomosynthesis System

Cited by 13 publications

References 20 publications

A Review of Breast Imaging for Timely Diagnosis of Disease

A Review of Breast Imaging for Timely Diagnosis of Disease

Digital breast tomosynthesis: a state-of-the-art review

PEGylation of Metal Oxide Nanoparticles Modulates Neutrophil Extracellular Trap Formation

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