A multiparameter analysis was conducted to evaluate the impact of meteorological parameters, night sky brightness and seismic hazards on proposed sites for the new optical/infrared Egyptian astronomical telescope. The European Centre for Medium-Range Weather Forecasts (ECMWF) Reanalysis v5 (ERA5) data set is used to obtain the following meteorological parameters: total cloud coverage fraction, precipitable water vapour, relative humidity, wind speed and direction, and air temperature. To estimate the aerosol optical depth, we used the Modern-Era Retrospective analysis for Research and Applications version 2 (MERRA-2). Light pollution over the candidate sites was measured using the Visible Infrared Imaging Radiometer Suite (VIIRS) day/night band. In order to assess the seismic hazards for the candidate sites, the seismic input in terms of maximum acceleration and response spectra was computed using a physics-based ground motion approach to assess the seismic hazards and, consequently, the designation of a seismic-resistant structure for the proposed sites. Of the seven nominated sites, two sites are found to have the best measurements and might be considered as future sites for the new Egyptian astronomical telescope. The first site is located in the south of the Sinai peninsula, while the second site is located in the Red Sea mountains region.