Preliminary Ecological Studies on Sponges of the Genus Agelas Spp.

Gaspar, Héléna; Gaudêncio, Susana P.; Medeiros, M. A.; Teixeira, Ana Clara Monte; Tavares, R.; Curto, Manuel; Devijver, C.; Braekman, Jean‐Claude; Gomez, Raquel; Kluijver, Mario de; Soest, R.W.M. van

doi:10.1007/978-94-015-9876-7_49

Cited by 2 publications

(2 citation statements)

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“…Compound (141) was not toxic at 50 mg/kg [213]. The influence of environmental factors, namely, depth and sponge-coral interactions, as well as the effects of infliction of standardized damage on the production of bromopyrrolic alkaloids isolated from the sponges A. dispar and A. conifera, were analyzed, and sceptrin was detected in both sponge species [215].…”

Section: Cyclobutane-containing Alkaloids From Marine Sourcesmentioning

confidence: 99%

Bioactive cyclobutane-containing alkaloids

2007

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The present review describes research on novel natural cyclobutane-containing alkaloids and synthetic compounds isolated from terrestrial and marine species. More than 210 compounds have been confirmed to show antimicrobial, antibacterial, anticancer, and other activities. Structures, origins, biosynthesis, photodimerization, and biological activities of a selection of cyclobutane-containing alkaloids and selected synthetic analogs of natural alkaloids are reviewed.

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Section: Cyclobutane-containing Alkaloids From Marine Sourcesmentioning

confidence: 99%

Bioactive cyclobutane-containing alkaloids

2007

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“…The compound ( 49 ) was not toxic at 50 mg/kg [ 94 , 95 ]. The influence of environmental factor, namely depth and sponge-coral interactions as well as the effects of infliction of standardized damages on the production of bromopyrrolic alkaloids isolated from the sponges Agelas dispar and Agelas conifera were analyzed and sceptrin ( 49 ) was detected in both sponge species [ 96 ]. More recently, sceptrin and eight dimeric bromopyrrole alkaloids, nagelamides A-H, and a monomeric one, 9,10-dihydrokeramadine, have been isolated from the Okinawan marine sponge Agelas sp.…”

Section: Cyclobutane-containing Alkaloids From Marine Speciesmentioning

confidence: 99%

Cyclobutane-Containing Alkaloids: Origin, Synthesis, and Biological Activities

Sergeiko

Poroikov²,

Hanŭs³

et al. 2008

TOMCJ

131

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Present review describes research on novel natural cyclobutane-containing alkaloids isolated from terrestrial and marine species. More than 60 biological active compounds have been confirmed to have antimicrobial, antibacterial, antitumor, and other activities. The structures, synthesis, origins, and biological activities of a selection of cyclobutane-containing alkaloids are reviewed. With the computer program PASS some additional biological activities are also predicted, which point toward new possible applications of these compounds. This review emphasizes the role of cyclobutane-containing alkaloids as an important source of leads for drug discovery.

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Preliminary Ecological Studies on Sponges of the Genus Agelas Spp.

Cited by 2 publications

References 3 publications

Bioactive cyclobutane-containing alkaloids

Bioactive cyclobutane-containing alkaloids

Cyclobutane-Containing Alkaloids: Origin, Synthesis, and Biological Activities

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