Preliminary evaluation of a hydrogel liquid bandage in 30 dogs undergoing tibial plateau levelling osteotomy surgery

Harrison, EJ; Scherrer, WE; Fragola, J; Patel, NG; Perry, SR; Jankovič, Vesna Novak; Staatz, A.

doi:10.1080/00480169.2016.1236710

Cited by 4 publications

(4 citation statements)

References 13 publications

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“…12 Therefore, several strategies have been employed clinically to attempt to lower the rate of infection, including use of antibiotic impregnated suture, extended postoperative antimicrobials, and implementation of preventive intraoperative and postoperative protocols. 6,9,11,[13][14][15] The objective of a systematic review is to identify, evaluate, and summarize the findings of all relevant individual studies about a specific issue, thereby making the available evidence more accessible to individuals and allowing them to make informed decisions. The objective of the systematic review reported here was to evaluate published data that could be used to determine whether the use of extended postoperative antibiotics after TPLO in dogs would reduce the risk of SSI.…”

Section: Introductionmentioning

confidence: 99%

“…Researchers in a recent study found that the cost of treating an SSI approached 50% of the original surgery cost and, in some, cases exceeded it 12 . Therefore, several strategies have been employed clinically to attempt to lower the rate of infection, including use of antibiotic impregnated suture, extended postoperative antimicrobials, and implementation of preventive intraoperative and postoperative protocols 6,9,11,13‐15 …”

Section: Introductionmentioning

confidence: 99%

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Efficacy of postoperative antibiotic use after tibial plateau leveling osteotomy in dogs: A systematic review

2021

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Objective: A systematic review of published data to determine whether postoperative antibiotic use after tibial plateau leveling osteotomy (TPLO) decreases infection rates. Study design: Systematic review.Methods: A broad bibliographic search was performed in three online databases through March 2020 for publications on postoperative antibiotic use after TPLO in dogs. Search terms included dog, canine, TPLO, tibial plateau leveling osteotomy, infection, antibiotic, and antimicrobial. Articles that met inclusion criteria were evaluated for level of evidence (LoE) by a modified Oxford Level of Evidence (mOLE) and GRADE (Grading of Recommendations, Assessment, Development and Evaluation) classification and evaluation.Results: Thirteen studies met the inclusion criteria. Effect of antibiotic use was the primary question in four studies. Among those, 50% (2/4) were assigned a mOLE of 1b and a GRADE of moderate, while the other 50% (2/4) were assigned a mOLE of 4b or 4c with a GRADE of low. The two studies with the highest LoE did not provide evidence of the benefit of antibiotic usage.Results of only one study provided evidence to support the use of postoperative antibiotics. The remaining nine studies provided evaluation of antibiotic use secondarily and were all assigned a low LoE. Among these, 78% (7/9) provided evidence to support the use of postoperative antibiotics. Conclusion:We found little evidence to support the use of postoperative antibiotics to reduce the risk of surgical site infections in dogs after TPLO. The answer to this clinical question is complicated by the lack of prospective studies and inconsistent treatment protocols in the evaluated studies.Clinical significance: The clinical impact of postoperative antibiotic administration on infection rates after TPLO is uncertain.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Efficacy of postoperative antibiotic use after tibial plateau leveling osteotomy in dogs: A systematic review

2021

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“…Surgical site infection (SSI) is one of the most common complications after TPLO (4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18). SSI undoubtedly has a negative impact on patient well-being, client satisfaction, and financial burden and often necessitates an additional anesthetic episode and surgical procedure for implant removal (19).…”

Section: Introductionmentioning

confidence: 99%

Biomechanical Comparison of Tibial Plateau Leveling Osteotomy Performed With a Novel Titanium Alloy Locking Plate Construct vs. an Established Stainless-Steel Locking Plate Construct

Bleakley¹,

Palmer

Miller³

et al. 2021

Front. Vet. Sci.

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A novel canine tibial plateau leveling osteotomy (TPLO) fixation device was recently developed with design features such as titanium alloy (TA) material, distal monocortical screw fixation, and a point contact undersurface specifically targeted to reduce surgical site infection rates by ensuring tissue perfusion under the plate. The strength of the novel TPLO construct was compared with that of a predicate stainless steel (SS) locking plate construct with bicortical screws in 16 paired cadaveric canine limbs. The mean loads to failure were 716.71 ± 109.50 N (range 455.69–839.69 N) and 629.50 ± 176.83 N (range 272.58–856.18 N) in the TA and SS groups, respectively. The average ratio of the loads to failure of the paired specimens was 1.18 (p = 0.031). No failure of the TA constructs involved the distal fixation with monocortical screws. Substantial mechanical equivalence of this novel TA monocortical/bicortical fixation construct to an established SS bicortical screw fixation construct is demonstrated. Clinical investigation of potential merits of this novel TA, monocortical/bicortical locking screw/plate system is now warranted.

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“…2,3,5,14,18,19 The use of postoperative wound dressings is not a standardized practice and there have been few veterinary studies evaluating their efficacy. [20][21][22] Potential benefits of postoperative wound dressings include protection from the environment and from patient self-trauma, both of which limit exposure to bacterial contamination. In a review on dressing use and SSI rate in human medicine, no significant difference was identified in the risk of SSI rate between patient groups in which a dressing was applied and those in which the wound was left uncovered.…”

Section: Introductionmentioning

confidence: 99%

Prospective Evaluation of Surgical Wound Dressings and the Incidence of Surgical Site Infections in Dogs Undergoing a Tibial Plateau Levelling Osteotomy

Giannetto¹,

Aktay²

2019

Vet Comp Orthop Traumatol

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Objective The main aim of this study was to evaluate the efficacy of a topical 2-octyl cyanoacrylate (2OC) tissue adhesive and an adhesive barrier dressing (BD) in minimizing the incidence of surgical site infections (SSI) in dogs undergoing a tibial plateau levelling osteotomy (TPLO). Materials and Methods In a prospective clinical study, 437 client-owned dogs undergoing a TPLO as treatment for cranial cruciate ligament disease with or without concurrent patellar luxations from July 2015 to September 2016 were included. In each dog, the type of postoperative wound dressing was randomly selected as either no dressing (ND), a 2OC tissue adhesive or an adhesive BD. Direct examination by a veterinarian was performed at 14, 30, 60 and 90 days postoperatively. If dogs did not return for direct examination, owners were contacted with a questionnaire for the final follow-up of at least 90 days. Results The overall rate of SSI was 2.3% (10/437). Methicillin-resistant Staphylococcus pseudintermedius was the most common bacteria isolated in 9/10 cases. Infection was confirmed in 2.76% (4/145) of dogs with ND, 2.01% (3/149) of dogs with 2OC and 2.10% (3/143) of dogs with BD. Of the dogs that developed an SSI, type of dressing was not a significant risk factor (p = 0.5305) for infection. Increasing body weight was the only significant risk factor that increased the risk of overall infection (odds ratio = 1.03 [95% confidence interval: 1.02–1.05]). Clinical Significance In dogs undergoing a TPLO, there may be no clear benefit in the usage of postoperative wound dressings for the prevention of SSI. Increasing body weight was the only significant factor associated with the development of an SSI.

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Preliminary evaluation of a hydrogel liquid bandage in 30 dogs undergoing tibial plateau levelling osteotomy surgery

Abstract: Due to several disadvantages of traditional bandaging, which can require post-operative maintenance and removal, lasts only a short time, and be painful when removed, an alternative with fewer drawbacks is desirable. HLB may present such an alternative.

Cited by 4 publications

References 13 publications

Efficacy of postoperative antibiotic use after tibial plateau leveling osteotomy in dogs: A systematic review

Efficacy of postoperative antibiotic use after tibial plateau leveling osteotomy in dogs: A systematic review

Biomechanical Comparison of Tibial Plateau Leveling Osteotomy Performed With a Novel Titanium Alloy Locking Plate Construct vs. an Established Stainless-Steel Locking Plate Construct

Prospective Evaluation of Surgical Wound Dressings and the Incidence of Surgical Site Infections in Dogs Undergoing a Tibial Plateau Levelling Osteotomy

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