Preliminary evaluation of the encapsulation of new antidiabetic sulphonylhydrazone and antitumor <i>N</i>-acylhydrazone derivatives using PLGA nanoparticles

Costa, Fanny N.; Ibiapino, Amanda Laura; Figueiredo, Laysa Pires de; Barreiro, Eliezer J.; Lima, Lı́dia Moreira; Amaral, Daniel Nascimento do; Castro, Carlos E. de; Giacomelli, Fernando C.; Ferreira, Fábio Furlan

doi:10.1088/1742-6596/617/1/012015

Cited by 5 publications

(3 citation statements)

References 16 publications

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“…The first one is, the presence of another diamagnetic layer besides the chitosan; and the second one is the contributions from intrinsic particles, shape and stress anisotropies due to different ligands along with interparticle interactions (dipolar), which can provide a difference in the energy barrier. Nanoparticles are strongly attracted by a magnetic field, and when this field is removed, their magnetization is reduced close to zero, without residual magnetization [54][55][56]. Figure 6a shows SEM images for nanoparticles containing IBU, in which the light green dots corresponds to iron (Fe, from magnetite core), dark green corresponds to oxygen (O, from magnetite, chitosan and ibuprofen) and red dots correspond to carbon (C, from chitosan and ibuprofen) atoms.…”

Section: Magnetic Measurementsmentioning

confidence: 99%

Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers

et al. 2020

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This article describes the synthesis, characterization, in vitro cytotoxic and genotoxicity evaluation of chitosan-iron oxide nanoparticles (Fe 3 O 4 -CS) as vehicles for ibuprofen (IBU) molecule. Magnetite (Fe 3 O 4 ) nanoparticles were synthesized by co-precipitation of iron salts and coated with chitosan, leading to the formation of Fe 3 O 4 -CS hybrid nanoparticles, and then IBU was adsorbed on the surface of the modified nanoparticles. The physicochemical, morphological, and magnetic properties of the nanoparticles were determined by X-ray powder diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy and SQUID magnetic measurements. The nanoparticles have shown stability in aqueous medium presenting an average hydrodynamic size of 36 ± 9 nm for Fe 3 O 4 -CS, and 132 ± 1 nm for Fe 3 O 4 -CS-IBU. The cytotoxicity of nanoparticles using the cell viability of the blood mononuclear cell fraction and the analysis of gene expression of the repair genes hMSH2, hMSH6 and NF-kB were performed to evaluate their applicability as drug carriers. The results showed that Fe 3 O 4 -CS nanoparticles are suitable candidates as magnetic vehicles for ibuprofen in biomedical applications. Graphic abstract

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Section: Magnetic Measurementsmentioning

confidence: 99%

Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers

et al. 2020

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“…(ix) PLGA concentration: it has been reported that increasing the polymer concentration in the solvent rises the entrapment of the active compound and the particle size [30][31][32]. Even though the literature has reported values from 5 to 100 mg/ml [33][34][35][36][37], the PLGA concentrations used were 10 (base case) and 20 mg/mL since higher concentrations could increase particle size. (x) Polymer molecular weight (Mw): this variable can affect both the releasing velocity and the entrapment efficiency of the active compound [30,38].…”

Section: Preparation Of Nanoparticlesmentioning

confidence: 99%

Improvement of N-Acetylcysteine Loaded in PLGA Nanoparticles by Nanoprecipitation Method

Lancheros

Guerrero

Godoy-Silva

2018

Journal of Nanotechnology

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N-Acetylcysteine (NAC) is a hydrophilic compound with a low bioavailability. It has been used as an effective antioxidant agent.is research seeks to enhance the entrapment of NAC in PLGA nanoparticles for drug delivery systems. e nanoparticles were made using the nanoprecipitation method and changing the following parameters: the solvent/nonsolvent nature, its viscosity, pH, NAC addition to the nonsolvent, the polymer concentration and molecular weight, and NAC concentration in the solvent.e results showed that an increase in the nonsolvent viscosity produces NAC concentration in the solvent, and the nonsolvent rises its entrapment in the nanoparticles. Nanoparticles with 235.5 ± 11.4 nm size with an entrapment efficiency of 0.4 ± 0.04% and a specific load of 3.14 ± 0.33% were obtained. e results suggest that besides efficiently entrapping hydrophobic compounds, the nanoprecipitation method also has a high potential as an alternative entrapment method for hydrophilic compounds as well. However, its use in the pharmaceutical industry, as a proper specific load vehicle, still depends on the improvement of the load capacity.

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“…Hydrazones have a diverse biological and pharmacological properties and can be associated with other functional groups to generate important molecular entities . Sulfonyl hydrazones are well-known for their pharmacological effects, such as enzymatic modulation, , analgesia, antifungal and antibacterial potential, − and can act as anti-Alzheimer, antinociceptive, , antidepressant, antineoplastic activity − and antidiabetic agents , (Figure ).…”

Section: Introductionmentioning

confidence: 99%

Environmentally Safe Condition for the Synthesis of Aryl and Alkyl Sulfonyl Hydrazones via One-Pot Reaction

Cunha

Tavares

Carvalho

et al. 2016

ACS Sustainable Chem. Eng.

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Sulfonyl hydrazones were synthesized by one-pot reaction using sulfonyl chlorides, hydrazine hydrate and aldehydes under mild, cheap and environmental safe conditions. The optimized reaction afforded nine products with yields higher than 94% and four products with yields between 34% and 83%. Also, this paper reports, for the first time, the reduction of hydrazine amount (1.2 equiv) in sulfonyl hydrazones synthesis, presenting an excellent perspective to the sustainable production of new drug candidates.

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Preliminary evaluation of the encapsulation of new antidiabetic sulphonylhydrazone and antitumor N-acylhydrazone derivatives using PLGA nanoparticles

Cited by 5 publications

References 16 publications

Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers

Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers

Improvement of N-Acetylcysteine Loaded in PLGA Nanoparticles by Nanoprecipitation Method

Environmentally Safe Condition for the Synthesis of Aryl and Alkyl Sulfonyl Hydrazones via One-Pot Reaction

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